DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and Kmt2a

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_038938273.1	Gene:	Kmt2a / 315606	RGDID:	1586165	Length:	3986	Species:	Rattus norvegicus

Alignment Length:	2052	Identity:	386/2052 - (18%)
Similarity:	644/2052 - (31%)	Gaps:	685/2052 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RPPKVALSALGNTPPHINPSLKHAD--------------------------AEASPTAPEDQDSG 60
            |||.|        .|.||.:::|.|                          :..||..|..|.|.
  Rat  2096 RPPVV--------EPDINSTVEHDDNRTIAHSPSSFIEASCKDSQSTAAILSPPSPDRPRSQASS 2152

  Fly    61 QSECRRSSR--------------------------------------KKIIKFDVRDLLNKNRKA 87
            ...|...|:                                      ..::...:|.:.::....
  Rat  2153 SCYCHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHST 2217

  Fly    88 HK---IQIEARIDSNPSTGHSQSGTTAAST-SMSTATASAASASSAATVSRLFSMFEMSHQSLPP 148
            ..   ::.:.||.|...:|...|.::.:|. |:.|||...:||.:......|.|...:.|.:...
  Rat  2218 SSLSPLRSKLRIMSPVRSGSVYSRSSVSSVPSLGTATDPESSAKATDRAGPLNSSANLGHSTPVS 2282

  Fly   149 PPPPPTALEIFAKP-------------------RPTQSLIVAQVTSEP---SAVGGAHPVQTMAG 191
            .....|.:...:|.                   .|..|.:..:....|   |..|.||.. ..:|
  Rat  2283 SGSQRTVVTGGSKTSHLDGSSSSGVKRSSASDLAPKGSSLKGEKNRTPGSKSTDGSAHNT-AYSG 2346

  Fly   192 LPPVTPR----KRGRPRKSQL---ADAAIIP----TVIVPSC------SDSDTNSTSTTTSNMS- 238
            :|.:.|:    ..|....|::   |:.:.:|    ||..|..      ||.|.:..||.:...|
  Rat  2347 IPKLAPQVLNAAPGELNVSKIGTFAEPSTVPFSKETVSYPQLHLRGQRSDRDQHMDSTQSVKPSP 2411

  Fly   239 SDSGE-----LPGF-----------------------PIQKPKSKLRVSLKRLKLGGRLESSDSG 275
            ::.||     |||.                       ...|...|.:.|.|.....|::.:.:.|
  Rat  2412 NEDGEIKTLKLPGMGHRPSILHEHVGSSSRDRRQKGKKSSKETCKEKHSSKSFLEPGQVTTGEEG 2476

  Fly   276 NSPSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEE 340
            |.....:.||..|..     :.:||      ...|.:::..|....:..:      |||:..|.|
  Rat  2477 NLKPEFADEVLTPGF-----LGQRP------CNNVSSDKTGDKILPLSGV------PKGQSTQVE 2524

  Fly   341 GRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRA-- 403
            |...|::......:.:...|.|.....:....|      |||.|. :..:.|...|.|:..|:
  Rat  2525 GSSKELQAPRKCSVKVTPLKMESENQSKNTQKE------SGPGSP-AHMESACPAEPASASRSPG 2582

  Fly   404 TPPGKEPAADSCSSA-----------------------------------PRRSRRS-------- 425
            ..||.:|:.::.||.                                   ||||.|:
  Rat  2583 AGPGVQPSPNNTSSQDPQSNNYQNLPEQDRNLMIPDGPKPQEDGSFKRRYPRRSARARSNMFFGL 2647

  Fly   426 APLSG------------SSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLSE 478
            .||.|            ||..||...:..||...:.:..:..::|.          ||.....:.
  Rat  2648 TPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDED----------DLYYYNFTR 2702

  Fly   479 SEVTSSVSPTIEHMVVEEVVVEENQL----VDEADEILDSKQEFVIKKVFSESD-NIAASLNKDI 538
            :.::|...   |.:....:..||.|.    :.:.|.:.|.          :||| ::.|:..|..
  Rat  2703 TVISSGGD---ERLASHNLFREEEQCDLPKISQLDGVDDG----------TESDTSVTATSRKSS 2754

  Fly   539 FEPKVETKATCGE--VVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEM-----IAETKLSDEV 596
            ..||...|....|  .:.|||...|..::.        ||||..|...::     ::..|...:.
  Rat  2755 QIPKRNGKENGTENLKIDRPEDAGEKEHVI--------KSAVGHKNEPKLDNCHSVSRVKAQGQD 2811

  Fly   597 VIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLET 661
            .:|..|......::.....|..|..::...:| :|.::.:..:|    .:|       |.:|...
  Rat  2812 SLEAQLSSLESSRRVHTSTPSDKNLLDTYNTE-LLKSDSDNNNS----DDC-------GNILPSD 2864

  Fly   662 SLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLE-----DYESNQEQVAEDE 721
            .:....|:      ||         |..|..|...|:|||    ||.     ..:||:|:  :..
  Rat  2865 IMDFVLKN------TP---------SMQALGESPESSSSE----LLTLGEGLGLDSNREK--DMG 2908

  Fly   722 MMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEK---AMENPA------RSSPAIVDKK-----V 772
            :.:..:|:      ||..:..:..|:.::|.:|:   .:|.|:      ..||.:..:.     |
  Rat  2909 LFEVFSQQ------LPATEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNSSRLAV 2967

  Fly   773 RAGEMEKKVVKSTKGTVPEKKMDSKKSCAA-----VTPAKQKESGKSAKEAILKKETEKEKSSA- 831
            .:...||:|      |:.||.:.|.:...|     |.||.:   |....:..::...:.:..|:
  Rat  2968 ISDSGEKRV------TITEKSVTSTEGDPALLSPGVDPAPE---GHMTPDHFIQGHMDADHISSP 3023

  Fly   832 ---------------KLDSSS-------------------PNTLDKKGKD-----TAQWSPQ--- 854
                           ..:||:                   ||:.|..|..     ..|.:|.
  Rat  3024 PCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLK 3088

  Fly   855 ------------------LQTLPKSSTK-----PPQESAPSVISKTTSNQPAPKEEQHAAKKGLS 896
                              |||||...|:     .|..|.|:|: :|.::...|.........||:
  Rat  3089 PATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSPVSSTPNVM-ETNTSVLGPMGSGLTLTTGLN 3152

  Fly   897 DNSPP--SVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPK-----V 954
            .:.||  |:.....|.:........:......|.:..             |..:.:||.     |
  Rat  3153 PSLPPSQSLFPPASKGLLSMPHHQHLHSFPAAAQSSF-------------PPNISSPPSGLLIGV 3204

  Fly   955 EPP-----------------TAVPVP--GQKKSLSGKTSLRRN---------------------T 979
            :||                 |.|..|  |.||....:...|:|                     |
  Rat  3205 QPPPDPQLLGSEANQRTDLTTTVTTPSSGLKKRPISRLHTRKNKKLAPSSAPSNIAPSDVVSNMT 3269

  Fly   980 VYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKK-----------INPRRSTICEAAKDLRSS 1033
            :...:|:...|.....|....|.|:.:..|:.:|:.           :.|.:|.....|    :.
  Rat  3270 LINFTPSQLSNHPSLLDLGSLNPSSHRTVPNIIKRSKSGIMYFEQAPLLPPQSVGGTTA----TG 3330

  Fly  1034 SSSSTPTREVA--ASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDR---------- 1086
            :.|||.:::.:  .|.|||..:..||..|.....|:.....|.......|:...|
  Rat  3331 AGSSTISQDTSHLTSGPVSALASGSSVLNVVSMQTTTTPTSSTSVPGHVTLANQRLLGTPDIGSI 3395

  Fly  1087 ----------------QPETAIPVPLTKRRF-----SMHPKASAN---------PLHDTLLQTAG 1121
                            ||   :.:|.:...|     |..|.|:|.         |...|...||.
  Rat  3396 SHLLIKASHQSLGIQDQP---VALPQSSGMFPQLGTSQTPSAAAMTAASSICVLPSSQTAGMTAA 3457

  Fly  1122 KKRGRKEGKESLSRQNSL------------DSSSSASQGAPKKKALKSAEILSAALLE------- 1167
            ......|.:..|.|.|.|            |....::.|.......::||..:...||
  Rat  3458 SPPREAEEQYKLQRVNQLLAGKTGTLSLQRDRDPDSAPGTQPSNFTQTAEAPNGVRLEQNKTLPS 3522

  Fly  1168 TESSESTSSGSKMSRWDVQTSPELEA-ANPFGDIAKF---IEDGVNLLKRDKVD----------- 1217
            .:.:.|||.||..|......|..:.. ..|...:.:.   ::.|..  |:.||.
  Rat  3523 AKQASSTSPGSSPSSGQQSGSSSVPGPTKPKPKVKRIQLPLDKGSG--KKHKVSHLRTSSEAHIP 3585

  Fly  1218 -EDQRKEGQDEVKREADPEEDEFAQRVANMETPA------------------TTPTPSPTQSNPE 1263
             .:.....|..|||  .|..|...|..|.:|.|:                  .|..|:..|.|.|
  Rat  3586 HREANPAPQPSVKR--TPRADREQQEAAGVEQPSQKECGQPAGPATALPEIQATQNPANEQENAE 3648

  Fly  1264 DSA------------------------STTT------VLKELETGGG------------------ 1280
            ..|                        |.|.      ::.|:.:..|
  Rat  3649 PKAVEEEESSFSSPLMLWLQQEQKRKESITERKPKKGLVFEISSDDGFQICAESIEDAWKSLTDK 3713

  Fly  1281 ---VRRSHRIKQKP-QGPRASQGRGVASVALAPISMDEQLA---------------ELANIEAIN 1326
               .|.:.|:||.. .|....:..|:...|:  :.:.|||:               |.||...:|
  Rat  3714 VQEARSNARLKQLSFAGVNGLRMLGILHDAV--VFLIEQLSGAKHCRNYKFRFHKPEEANEPPLN 3776

  Fly  1327 -------EQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINR 1384
                   |..||....:.|..|....    ||..:.|.        ..:||.:..|.......:.
  Rat  3777 PHGSARAEVHLRKSAFDMFNFLASKH----RQPPEYNP--------NDEEEEEVQLKSARRATSM 3829

  Fly  1385 MLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEE 1449
            .|.:   |:.....:.|:|.       ...|:|:...|.|:..:..|..||.::||.|.||.|.:
  Rat  3830 DLPM---PMRFRHLKKTSKE-------AVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQ 3884

  Fly  1450 FERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSV 1514
            .::|:..|. .:....|...:....|:|||..||.:|:|||||:||..::...::|:..|..|::
  Rat  3885 TDKREKYYD-SKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAM 3948

  Fly  1515 KPIQPGEEITFDYQY-LRYGRDAQRCYCEAANCRGWI 1550
            :.|..|||:|:||:: :....:...|.|.|..||.::
  Rat  3949 RKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFL 3985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	7/51 (14%)
		SET	1414..1533	CDD:214614	40/119 (34%)
		PostSET	1535..1551	CDD:214703	5/16 (31%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Kmt2a	XP_038938273.1	zf-CXXC	1145..1192	CDD:366873
		PHD1_KMT2A	1451..1497	CDD:277063
		PHD2_KMT2A	1499..1548	CDD:277065
		PHD3_KMT2A	1586..1645	CDD:277067
		Bromo_ALL-1	1668..1798	CDD:99925
		ePHD_KMT2A	1892..2004	CDD:277163
		FYRN	2045..2092	CDD:399155
		FYRC	3686..3769	CDD:197781	12/84 (14%)
		SET_KMT2A_2B	3833..3986	CDD:380947	48/164 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351991
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840