Protein Alignment Set2 and Kmt2a

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_063121507.1
• Gene: Kmt2a / 315606
• RGDID: 1586165
• Length: 4017
• Species: Rattus norvegicus
• Alignment Length: 2052
• Identity: 386/2052 - (18%)
• Similarity: 644/2052 - (31%)
• Gaps: 685/2052 - (33%)

  Fly    22 RPPKVALSALGNTPPHINPSLKHAD--------------------------AEASPTAPEDQDSG 60
            |||.|        .|.||.:::|.|                          :..||..|..|.|.
  Rat  2127 RPPVV--------EPDINSTVEHDDNRTIAHSPSSFIEASCKDSQSTAAILSPPSPDRPRSQASS 2183

  Fly    61 QSECRRSSR--------------------------------------KKIIKFDVRDLLNKNRKA 87
            ...|...|:                                      ..::...:|.:.::....
  Rat  2184 SCYCHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHST 2248

  Fly    88 HK---IQIEARIDSNPSTGHSQSGTTAAST-SMSTATASAASASSAATVSRLFSMFEMSHQSLPP 148
            ..   ::.:.||.|...:|...|.::.:|. |:.|||...:||.:......|.|...:.|.:...
  Rat  2249 SSLSPLRSKLRIMSPVRSGSVYSRSSVSSVPSLGTATDPESSAKATDRAGPLNSSANLGHSTPVS 2313

  Fly   149 PPPPPTALEIFAKP-------------------RPTQSLIVAQVTSEP---SAVGGAHPVQTMAG 191
            .....|.:...:|.                   .|..|.:..:....|   |..|.||.. ..:|
  Rat  2314 SGSQRTVVTGGSKTSHLDGSSSSGVKRSSASDLAPKGSSLKGEKNRTPGSKSTDGSAHNT-AYSG 2377

  Fly   192 LPPVTPR----KRGRPRKSQL---ADAAIIP----TVIVPSC------SDSDTNSTSTTTSNMS- 238
            :|.:.|:    ..|....|::   |:.:.:|    ||..|..      ||.|.:..||.:...|
  Rat  2378 IPKLAPQVLNAAPGELNVSKIGTFAEPSTVPFSKETVSYPQLHLRGQRSDRDQHMDSTQSVKPSP 2442

  Fly   239 SDSGE-----LPGF-----------------------PIQKPKSKLRVSLKRLKLGGRLESSDSG 275
            ::.||     |||.                       ...|...|.:.|.|.....|::.:.:.|
  Rat  2443 NEDGEIKTLKLPGMGHRPSILHEHVGSSSRDRRQKGKKSSKETCKEKHSSKSFLEPGQVTTGEEG 2507

  Fly   276 NSPSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEE 340
            |.....:.||..|..     :.:||      ...|.:::..|....:..:      |||:..|.|
  Rat  2508 NLKPEFADEVLTPGF-----LGQRP------CNNVSSDKTGDKILPLSGV------PKGQSTQVE 2555

  Fly   341 GRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRA-- 403
            |...|::......:.:...|.|.....:....|      |||.|. :..:.|...|.|:..|:
  Rat  2556 GSSKELQAPRKCSVKVTPLKMESENQSKNTQKE------SGPGSP-AHMESACPAEPASASRSPG 2613

  Fly   404 TPPGKEPAADSCSSA-----------------------------------PRRSRRS-------- 425
            ..||.:|:.::.||.                                   ||||.|:
  Rat  2614 AGPGVQPSPNNTSSQDPQSNNYQNLPEQDRNLMIPDGPKPQEDGSFKRRYPRRSARARSNMFFGL 2678

  Fly   426 APLSG------------SSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLSE 478
            .||.|            ||..||...:..||...:.:..:..::|.          ||.....:.
  Rat  2679 TPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDED----------DLYYYNFTR 2733

  Fly   479 SEVTSSVSPTIEHMVVEEVVVEENQL----VDEADEILDSKQEFVIKKVFSESD-NIAASLNKDI 538
            :.::|...   |.:....:..||.|.    :.:.|.:.|.          :||| ::.|:..|..
  Rat  2734 TVISSGGD---ERLASHNLFREEEQCDLPKISQLDGVDDG----------TESDTSVTATSRKSS 2785

  Fly   539 FEPKVETKATCGE--VVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEM-----IAETKLSDEV 596
            ..||...|....|  .:.|||...|..::.        ||||..|...::     ::..|...:.
  Rat  2786 QIPKRNGKENGTENLKIDRPEDAGEKEHVI--------KSAVGHKNEPKLDNCHSVSRVKAQGQD 2842

  Fly   597 VIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLET 661
            .:|..|......::.....|..|..::...:| :|.::.:..:|    .:|       |.:|...
  Rat  2843 SLEAQLSSLESSRRVHTSTPSDKNLLDTYNTE-LLKSDSDNNNS----DDC-------GNILPSD 2895

  Fly   662 SLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLE-----DYESNQEQVAEDE 721
            .:....|:      ||         |..|..|...|:|||    ||.     ..:||:|:  :..
  Rat  2896 IMDFVLKN------TP---------SMQALGESPESSSSE----LLTLGEGLGLDSNREK--DMG 2939

  Fly   722 MMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEK---AMENPA------RSSPAIVDKK-----V 772
            :.:..:|:      ||..:..:..|:.::|.:|:   .:|.|:      ..||.:..:.     |
  Rat  2940 LFEVFSQQ------LPATEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNSSRLAV 2998

  Fly   773 RAGEMEKKVVKSTKGTVPEKKMDSKKSCAA-----VTPAKQKESGKSAKEAILKKETEKEKSSA- 831
            .:...||:|      |:.||.:.|.:...|     |.||.:   |....:..::...:.:..|:
  Rat  2999 ISDSGEKRV------TITEKSVTSTEGDPALLSPGVDPAPE---GHMTPDHFIQGHMDADHISSP 3054

  Fly   832 ---------------KLDSSS-------------------PNTLDKKGKD-----TAQWSPQ--- 854
                           ..:||:                   ||:.|..|..     ..|.:|.
  Rat  3055 PCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLK 3119

  Fly   855 ------------------LQTLPKSSTK-----PPQESAPSVISKTTSNQPAPKEEQHAAKKGLS 896
                              |||||...|:     .|..|.|:|: :|.::...|.........||:
  Rat  3120 PATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSPVSSTPNVM-ETNTSVLGPMGSGLTLTTGLN 3183

  Fly   897 DNSPP--SVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPK-----V 954
            .:.||  |:.....|.:........:......|.:..             |..:.:||.     |
  Rat  3184 PSLPPSQSLFPPASKGLLSMPHHQHLHSFPAAAQSSF-------------PPNISSPPSGLLIGV 3235

  Fly   955 EPP-----------------TAVPVP--GQKKSLSGKTSLRRN---------------------T 979
            :||                 |.|..|  |.||....:...|:|                     |
  Rat  3236 QPPPDPQLLGSEANQRTDLTTTVTTPSSGLKKRPISRLHTRKNKKLAPSSAPSNIAPSDVVSNMT 3300

  Fly   980 VYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKK-----------INPRRSTICEAAKDLRSS 1033
            :...:|:...|.....|....|.|:.:..|:.:|:.           :.|.:|.....|    :.
  Rat  3301 LINFTPSQLSNHPSLLDLGSLNPSSHRTVPNIIKRSKSGIMYFEQAPLLPPQSVGGTTA----TG 3361

  Fly  1034 SSSSTPTREVA--ASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDR---------- 1086
            :.|||.:::.:  .|.|||..:..||..|.....|:.....|.......|:...|
  Rat  3362 AGSSTISQDTSHLTSGPVSALASGSSVLNVVSMQTTTTPTSSTSVPGHVTLANQRLLGTPDIGSI 3426

  Fly  1087 ----------------QPETAIPVPLTKRRF-----SMHPKASAN---------PLHDTLLQTAG 1121
                            ||   :.:|.:...|     |..|.|:|.         |...|...||.
  Rat  3427 SHLLIKASHQSLGIQDQP---VALPQSSGMFPQLGTSQTPSAAAMTAASSICVLPSSQTAGMTAA 3488

  Fly  1122 KKRGRKEGKESLSRQNSL------------DSSSSASQGAPKKKALKSAEILSAALLE------- 1167
            ......|.:..|.|.|.|            |....::.|.......::||..:...||
  Rat  3489 SPPREAEEQYKLQRVNQLLAGKTGTLSLQRDRDPDSAPGTQPSNFTQTAEAPNGVRLEQNKTLPS 3553

  Fly  1168 TESSESTSSGSKMSRWDVQTSPELEA-ANPFGDIAKF---IEDGVNLLKRDKVD----------- 1217
            .:.:.|||.||..|......|..:.. ..|...:.:.   ::.|..  |:.||.
  Rat  3554 AKQASSTSPGSSPSSGQQSGSSSVPGPTKPKPKVKRIQLPLDKGSG--KKHKVSHLRTSSEAHIP 3616

  Fly  1218 -EDQRKEGQDEVKREADPEEDEFAQRVANMETPA------------------TTPTPSPTQSNPE 1263
             .:.....|..|||  .|..|...|..|.:|.|:                  .|..|:..|.|.|
  Rat  3617 HREANPAPQPSVKR--TPRADREQQEAAGVEQPSQKECGQPAGPATALPEIQATQNPANEQENAE 3679

  Fly  1264 DSA------------------------STTT------VLKELETGGG------------------ 1280
            ..|                        |.|.      ::.|:.:..|
  Rat  3680 PKAVEEEESSFSSPLMLWLQQEQKRKESITERKPKKGLVFEISSDDGFQICAESIEDAWKSLTDK 3744

  Fly  1281 ---VRRSHRIKQKP-QGPRASQGRGVASVALAPISMDEQLA---------------ELANIEAIN 1326
               .|.:.|:||.. .|....:..|:...|:  :.:.|||:               |.||...:|
  Rat  3745 VQEARSNARLKQLSFAGVNGLRMLGILHDAV--VFLIEQLSGAKHCRNYKFRFHKPEEANEPPLN 3807

  Fly  1327 -------EQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINR 1384
                   |..||....:.|..|....    ||..:.|.        ..:||.:..|.......:.
  Rat  3808 PHGSARAEVHLRQSAFDMFNFLASKH----RQPPEYNP--------NDEEEEEVQLKSARRATSM 3860

  Fly  1385 MLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEE 1449
            .|.:   |:.....:.|:|.       ...|:|:...|.|:..:..|..||.::||.|.||.|.:
  Rat  3861 DLPM---PMRFRHLKKTSKE-------AVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQ 3915

  Fly  1450 FERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSV 1514
            .::|:..|. .:....|...:....|:|||..||.:|:|||||:||..::...::|:..|..|::
  Rat  3916 TDKREKYYD-SKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAM 3979

  Fly  1515 KPIQPGEEITFDYQY-LRYGRDAQRCYCEAANCRGWI 1550
            :.|..|||:|:||:: :....:...|.|.|..||.::
  Rat  3980 RKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFL 4016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	27/157 (17%)
		AWS	1358..1410	CDD:197795	7/51 (14%)
		SET_SETD2	1410..1551	CDD:380949	45/142 (32%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
Kmt2a	XP_063121507.1	None