Protein Alignment Set2 and Ezh2

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_006236463.1
• Gene: Ezh2 / 312299
• RGDID: 1595860
• Length: 751
• Species: Rattus norvegicus
• Alignment Length: 720
• Identity: 158/720 - (21%)
• Similarity: 245/720 - (34%)
• Gaps: 236/720 - (32%)

  Fly   880 NQPAPKEEQHAAKKGLSDN------SPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNK 938
            :.|..:||:   :|.|.|:      .||....|           |.:|:|:..........|:.|
  Rat   191 DDPDEREEK---QKDLDDSRDDKETCPPRKFPA-----------DKIFEAISSMFPDKGTAEELK 241

  Fly   939 KKLKKVPTKVEAP--------PKVEPPTAVPVPGQKKSLSGKTSLRR-------------NTVYE 982
            :|.|:: |:.:.|        |.::.|.|..|..::...|..|...|             |..:.
  Rat   242 EKYKEL-TEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHRKCNYSFH 305

  Fly   983 DSPNL--ERNSSPSSDSAQ-----------ANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSS 1034
            .:||.  .:|:..:.|:..           |...|..|...::|..  |:|.......:...:||
  Rat   306 ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTP--PKRPGGRRRGRLPNNSS 368

  Fly  1035 SSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKR 1099
            ..||||..|.      .|.|:.|.|.....|     ||...|:..    |:::.||:
  Rat   369 RPSTPTISVL------ESKDTDSDREAGTET-----GGENNDKEE----EEKKDETS-------- 410

  Fly  1100 RFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAA 1164
                 ..:.||    :..||..|.:...|..|::..     |.:.||.          ..:|...
  Rat   411 -----SSSEAN----SRCQTPIKMKPNIEPPENVEW-----SGAEASM----------FRVLIGT 451

  Fly  1165 LLETESSESTSSGSKMSR----WDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQ 1225
            ..:...:.:...|:|..|    :.|:.| .:.|..|..|                ||...||:.:
  Rat   452 YYDNFCAIARLIGTKTCRQVYEFRVKES-SIIAPVPTED----------------VDTPPRKKKR 499

  Fly  1226 DEVK-----READPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSH 1285
            ....     |:...::|..:..|.|.:     |...|.|  |.||:....:.:.
  Rat   500 KHRLWAAHCRKIQLKKDGSSNHVYNYQ-----PCDHPRQ--PCDSSCPCVIAQN----------- 546

  Fly  1286 RIKQKPQGPRASQGRGVASVALAPISMDEQLAELANIEAINEQFLR--SEGLNTFQLLKENFYRC 1348
                                                   ..|:|.:  ||..|.|.     ..||
  Rat   547 ---------------------------------------FCEKFCQCSSECQNRFP-----GCRC 567

  Fly  1349 ARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGP-LCSNGARCTNKRFQQHQCWP 1412
            ..|.:.:    ||.|:|.                    :.||.| ||.......:...:...|..
  Rat   568 KAQCNTK----QCPCYLA--------------------VRECDPDLCLTCGAADHWDSKNVSCKN 608

  Fly  1413 CRVFRTEKK----------GCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYF 1467
            |.:.|..||          |.||..:..:...|||.||.||:|..:|.:||..:|  |:....:.
  Rat   609 CSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVY--DKYMCSFL 671

  Fly  1468 MALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQY--- 1529
            ..|..:.|:|||.|||..|:.|||.:||...:...|||:.|||.|:.:.||.|||:.|||:|
  Rat   672 FNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQA 736

  Fly  1530 --LRY 1532
              |:|
  Rat   737 DALKY 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855
		AWS	1358..1410	CDD:197795	9/52 (17%)
		SET_SETD2	1410..1551	CDD:380949	53/138 (38%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
Ezh2	XP_006236463.1	EZH2_WD-Binding	39..68	CDD:463308
		PRC2_HTH_1	158..249	CDD:436286	16/72 (22%)
		preSET_CXC	564..595	CDD:408079	12/54 (22%)
		SET_EZH2	614..733	CDD:380995	47/120 (39%)