Protein Alignment Set2 and Ash1l

DIOPT Version :9

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_008759376.1
• Gene: Ash1l / 310638
• RGDID: 1306350
• Length: 2958
• Species: Rattus norvegicus
• Alignment Length: 2735
• Identity: 542/2735 - (19%)
• Similarity: 909/2735 - (33%)
• Gaps: 933/2735 - (34%)

  Fly    21 GRPPKVALSALG---NTPPHIN--------PSLKHADAEASPTAPEDQDSGQSECRRSSRKKIIK 74
            |:.|.:| |..|   .||..:|        |.||    ..:..||:...........|.:.|.:|
  Rat   650 GKKPSLA-SDSGIHTITPSVVNFTSLFSNKPFLK----LGAVAAPDKHCQVAESLSTSFQSKPLK 709

  Fly    75 FDVRDLLNKNRKAHKIQIEARIDSNPSTG--------------HSQSGTTAASTSMSTATASA-- 123
                  ..|.|||...::.||.......|              .|.|.::..:..|.|..||:
  Rat   710 ------KRKGRKARWTKVVARSTCRSPKGLDLERSELFKNVSCSSLSNSSEPAKFMKTIGASSFV 768

  Fly   124 -----------ASASSAATVSRLFSMFEMSHQSLPPPPPPPTALEIFAKPRPTQSLIVAQVTSEP 177
                       .|.|||.:::.|....:.||:|             |...:.:.|:.   |||:.
  Rat   769 DHDFLKRRLPKLSKSSAPSLALLADSEKASHKS-------------FITHKLSSSMC---VTSDL 817

  Fly   178 SAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAAIIP--TVIVPSCSDSDTNSTSTTTSNMSSD 240
                          |..:...|||||:..::......|  |:.:|:.......|.......:...
  Rat   818 --------------LSDIYKPKRGRPKSKEMPQLEGPPKRTLKIPASKVFSLQSKEEQEPPILQP 868

  Fly   241 SGELPGF-------PIQK----PKSKLR--VSLKRLKLG----------GRLESSDSGNSPSSSS 282
            ..|:|.|       |..|    ||.::|  |.:|...|.          .:|| |:|.|..|||.
  Rat   869 EIEIPSFKQSLSVSPFPKKRGRPKRQMRSPVKMKPPVLSVAPFVATESPSKLE-SESENHRSSSD 932

  Fly   283 PEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSD---------------------------- 319
            .......|||.:.:::  ...|::..:.|.|...|..
  Rat   933 FFESEDQLQDTDDLED--SHRQSVCSVSDLEMEPDKKISKRNNGQLMKTIIRKINKMKTLKRKKL 995

  Fly   320 -SQIIFIEIETESPKGEEE---------------QEEGRPVEVEPQDLIDIDMELAKQEPTPDPE 368
             :||:...:|: |.||:.:               .:.|:.:.|..:..|.|.....::..|
  Rat   996 LNQILSSSVES-SNKGKVQSKLHNTVSSLAATFGSKLGQQINVSKKGTIYIGKRRGRKPKT---- 1055

  Fly   369 EDLDEIMVEVLSG-PPSLWSADDEAEEEEDATVQRATPP-GKEPAADS-------CSSAPRRSRR 424
                 ::..:||| |.||...:..|::...:.:.:..|| ...||:.|       ||.:...|..
  Rat  1056 -----VLNGLLSGSPASLAVLEQTAQQAAGSALGQILPPLLPSPASSSEILPSPICSQSSGTSGG 1115

  Fly   425 SAPLSGS---------------SRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIED 474
            .:|:|..               ||||..: :|.|...|...::.|...........|:
  Rat  1116 QSPVSSDAGFVEPSSVPYLHVHSRQGSMI-QTLAMKKAAKGRRRLSPPTLLPNSPSHL------- 1172

  Fly   475 TLSESEVTS----SVSPTIEHMVVEEVV------VEENQLVDEADEILDSKQ---EFV-IKKVFS 525
                ||:||    :.||..|....|.:.      .:.|...|.|::....|:   .|. |..:..
  Rat  1173 ----SELTSLKEATPSPVSESHSDETIPSDSGIGTDNNSTSDRAEKFCGQKKRRHSFEHISLIPP 1233

  Fly   526 ESDNIAASLNKD-------------IFEPKVETKATCGEVVPR------PEMVTE---------D 562
            |:..:..||.:.             .::.....|....:..|:      |:.:.|         :
  Rat  1234 ETSTVLNSLKEKHKHKCKRRSHDYLSYDKMKRQKRKRKKKYPQLRNRQDPDFIAELEELISRLSE 1298

  Fly   563 VYIT--------EGIAATLEK---SAVVTKPTTEMIAETKLSDEV--VIEPPLKDE--SDPKQTE 612
            :.||        ..:..|:.:   ::..|.|:..:       |.:  :.:|.||.:  ..||..|
  Rat  1299 IRITHRSHHFIPRDLLPTIFRINFNSFYTHPSFPL-------DPLHYIRKPDLKKKRGRPPKMRE 1356

  Fly   613 ----------VELPESK----PAVNIPKSERILSA-------------------EVETTSSPLVP 644
                      :..|.|.    |:..:|.|...|:|                   ...:.::||.|
  Rat  1357 AMAEMPFMHSLSFPLSSTGFYPSYGMPYSPSPLTAAPIGLGYYGRYPPTLYPPPPSPSFTTPLPP 1421

  Fly   645 PECCTLESVSGPVLLETSLSTEEKS---NENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFL 706
            |....    :|.:||..:...::|.   .:....|..:|......:.|:.|.|.|.      .::
  Rat  1422 PSYMH----AGHLLLNPTKYHKKKHKLLRQEAFLTTSRTPLLSMSTYPSVPPEMAY------GWM 1476

  Fly   707 LE----------DYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPA 761
            :|          ::.|.|.||:.|        .|..::.|..:
  Rat  1477 VEHKHRHRHKHREHRSEQPQVSMD--------TGSSRSVLESL---------------------- 1511

  Fly   762 RSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKK-----SCAAVTPAKQKESGKSAKEAILK 821
                    |:.|.|          |.||.::....:|     ||..::|:|          :::.
  Rat  1512 --------KRYRFG----------KDTVGDRYKHKEKHRCHMSCPHLSPSK----------SLIN 1548

  Fly   822 KETE------KEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSN 880
            :|.:      .|.||..|...:|..:|                       ..||:||:
  Rat  1549 REEQWVSREPSESSSLALGLQTPLQID-----------------------CSESSPSL------- 1583

  Fly   881 QPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVP 945
                      :..|.:.||.|:             ..|........|....|:...|....||:
  Rat  1584 ----------SLGGFTPNSEPA-------------SSDEHMNLFTSAIGSCRVSNPNSSCRKKL- 1624

  Fly   946 TKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPS 1010
                    .:.|...||.        .|:|.|....|..|:.||.....:.|..|:.     |||
  Rat  1625 --------TDSPGLFPVQ--------DTALSRPHRKEPLPSTERAIQSLAGSQSASD-----KPS 1668

  Fly  1011 KVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSP--VSTSSDS---------------SSK 1058
            :     ....||.|...:...||.|:|:....:.:.||  |::..||               |.:
  Rat  1669 Q-----RSSESTNCSPTRKRSSSESTSSTVNGIPSRSPRLVASLDDSVDCLLQRIVQHDEQESVE 1728

  Fly  1059 RNGSKRTTS-----DLDGGSKLDQRRYTICEDRQPETAIP------VPLTKRRFSMHPKASANPL 1112
            :||....|:     ....|....:.|.....|.....|:|      :||...:.:  .:.|.:.:
  Rat  1729 KNGDAPITTVSAPPSSSPGHSYSKERTLGKSDSLLVPAVPSDSCNSIPLLSEKLA--SRCSPHHI 1791

  Fly  1113 HDTLLQTAGKKRGRK--------EGKESLSRQNSLDSSSSASQ-------------GAPKK---K 1153
            ..:::: |.:::.||        ..|::|...|.:..:....:             |.|:|   :
  Rat  1792 KRSVVE-AMQRQARKMCNYDKILATKKNLDHVNKILKAKKLQRQARTGNNFVKRRPGRPRKCPLQ 1855

  Fly  1154 ALKSAEILSAA-LLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDK-- 1215
            |:.|.:...|| .:..|.:|    |.::|   :..||:...     |:.:.:...|||....|
  Rat  1856 AVVSMQAFQAAQFVNPELNE----GEEVS---LHLSPDTVT-----DVIEAVVQSVNLNSEHKKG 1908

  Fly  1216 -------VDEDQRKEGQDEVKREADPEEDE------FAQRVANMETPATTPT-PSPTQSN----- 1261
                   ::|..||      |::..|||:|      |.::...:.:|..||. ||..:||
  Rat  1909 WKRKNWLLEEQTRK------KQKTVPEEEEQENNKSFIEKPVEIPSPLETPAEPSEPESNLQPVL 1967

  Fly  1262 ---PEDSASTTTVLKELETGGGVR--------RSHRIKQKPQGPRASQGRGVASVALAPISMDEQ 1315
               |.:..:.....|:.:..|...        :|..|:.|.:....:.|.....:..|||.:.:.
  Rat  1968 ALIPREKKAPRPPKKKYQRAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVGKY 2032

  Fly  1316 LAELANIEAI-------------NEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTG 1367
            |.:    :.|             :.|..:...:..::.::.|.|...:.:|...| ..|:|....
  Rat  2033 LRQ----KRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEA-TTCNCKKPD 2092

  Fly  1368 DEEAQGHLSCGAGCINRMLMIECGP-LCSNGARCTNKRFQQHQCWPC-RVFRTEKKGCGITAELL 1430
            |:..:|   ||..|:|||:..||.| .|..|.:|.|:|.|:|:...| ..||.|:||.||..:..
  Rat  2093 DDTRKG---CGDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEP 2154

  Fly  1431 IPPGEFIMEYVGEVIDSEEFERRQ----HLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHS 1491
            :..|:||:||:|||:..:||..|.    |.:|     .:|.:.|....|||:...||.:|:||||
  Rat  2155 LKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHS-----DHYCLNLDSGMVIDSYRMGNEARFINHS 2214

  Fly  1492 CDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQR-CYCEAANCRGWIGGEPD 1555
            ||||.|.|||:|||..|||.:::|.:..|.|:|:||.:..:..:.|: |.|....|||.|||:..
  Rat  2215 CDPNCEMQKWSVNGVYRIGLYALKDVPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQ 2279

  Fly  1556 SDEGEQLDEESDSDAEMDEEELEAEPEEGQP----RKSAKAKAKSKLKAKLPLATGRKRKEQTKP 1616
            ...|  |.....|                ||    ||||::|.|.|.|.||       :|.:..|
  Rat  2280 RMNG--LPSHKGS----------------QPASTHRKSARSKEKRKSKHKL-------KKRRGHP 2319

  Fly  1617 KDREYKAGRWLKPSATGSSSSAEKP--PKKPKVNKFQAMLEDPDVVEELSLLRRGGLK--NQQDT 1677
            .:         :||...::.:...|  ..||..|:     |...|::....|.|...|  .:|:.
  Rat  2320 SE---------EPSENINTPTRLTPQLQMKPMSNR-----ERNFVLKHHVFLVRNWEKIHQKQEE 2370

  Fly  1678 LRFSRCLVRAKLLKTRLALLRVLTHGELPCRRLFLDYHGLRLLHAWISENG---NDDQLREALLD 1739
            ::.||                              |.|...|...|   ||   :|..::..:.
  Rat  2371 VKHSR------------------------------DIHSTSLYTRW---NGICRDDGNIKSDVF- 2401

  Fly  1740 TLESLPIPNRTMLSDSRVYQSVQLWSNSLEQQLAVVPQEKQAALHKRMVALLQKWQALPEIFRIP 1804
                     .|..|..:..:||:      .::||...:..:.|...|:.      |...||.
  Rat  2402 ---------MTQFSALQTARSVR------TRRLAAAEENLEVARAARLA------QIFKEIC--- 2442

  Fly  1805 KRERIEQMKEHEREADRQQKHVHASTALEDQRERESSNDRFRQDRFRRDTTSSRIGKPIRMSGNN 1869
              :.|...|:..::|        .:..|.:...::.:.|.:           .:|..|:.:|
  Rat  2443 --DGIISYKDSSQQA--------LAAPLLNLPPKKKNADYY-----------EKISDPLDLS--- 2483

  Fly  1870 TICTITTQQKGSNG------APDG----MTRNDNR---RRSDIGPPSEQRRTLSKELRRSLFERK 1921
                 |.:::...|      |.|.    :.||..:   |:|.||      |.:.: ||::.:.
  Rat  2484 -----TIEKQILTGYYKTVEAFDADMLKVFRNAEKYYGRKSPIG------RDVCR-LRKAYYS-- 2534

  Fly  1922 VALDEAERRVCTEDRLEHELRCEFFGADINTDPKQLPFYQKTDTNEWFNSDDV--PVPAPPRTEL 1984
             |..||..::   |.:..|...|       .|..:....:|.:::|  ..|||  .:....:.|.
  Rat  2535 -ARHEASAQI---DEIVGETASE-------ADSSETSVSEKENSHE--KDDDVIRCICGLYKDEG 2586

  Fly  1985 L----TKALLSPDIDVGQGATDVEYKLPPGVDPLP--------PAWNWQVTSDGDIYY------- 2030
            |    .|.::....|.....||||:.|....||.|        |..::  ...|.:|:
  Rat  2587 LMIQCDKCMVWQHCDCMGVNTDVEHYLCEQCDPRPVDREVPMIPRPHY--AQPGCVYFICLLRDD 2649

  Fly  2031 ---------YNLRE--RISQWEPPSPEQRLQT-------------LLEENTTQQPL--------- 2062
                     |.:|:  |.....|.....||.:             .|.:|..::..
  Rat  2650 LLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKLDIFRIEKLWKNEKEERFAFGHHYFRP 2714

  Fly  2063 HELQIDPA--VLENELIQVD-------TDYVGSLSAKSLAQYIEAK---VRERR----DLRRSKL 2111
            ||....|:  ...|||.:|.       ...||:.....|..|.:.:   |:|:.    |.|..|.
  Rat  2715 HETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYICDYRLDKS 2779

  Fly  2112 VSI----------------------RLISPRRDEDRLYNQLESRKYKEN----KEKIRRRKELYR 2150
            ..:                      :.::|:||....|   ....||.|    ..|..|.|.|.:
  Rat  2780 AHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKRDFSPHY---VPDNYKRNGGRSSWKSERSKPLLK 2841

  Fly  2151 RRKIEVLPDAVDEIPVPGKALPIQPYLFSSDEEETKVAAIEQPAAEEEQDSLNMAPSTSHAAMAA 2215
                        ::.....|||:...:.:|.|:    ||.|.|:.||
  Rat  2842 ------------DLGQDDDALPLIEEVLASQEQ----AANEMPSPEE------------------ 2872

  Fly  2216 LGKAVAQPTGLGTVGKRKLPMPPSVTVKKHRQEQRSKKVKSSQSPLTATSAREAHEKFRFEISGH 2280
                                 |....|.....:...|..:|||.|..|::..|.....|..::..
  Rat  2873 ---------------------PDQERVTGDVSDAEKKPEESSQEPQLASTPEERRHSQRERLNQI 2916

  Fly  2281 VANFL 2285
            :.|.|
  Rat  2917 LLNLL 2921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	20/52 (38%)
		SET	1414..1533	CDD:214614	52/122 (43%)
		PostSET	1535..1551	CDD:214703	6/16 (38%)
		WW	2014..2043	CDD:278809	7/54 (13%)
		SRI	2270..2348	CDD:285448	3/16 (19%)
Ash1l	XP_008759376.1	AWS	2082..2133	CDD:197795	21/54 (39%)
		SET_ASH1L	2136..2276	CDD:380951	60/144 (42%)
		Bromo_ASH1	2432..2537	CDD:99955	26/152 (17%)
		PHD_ASH1L	2575..2617	CDD:277023	9/41 (22%)
		BAH_polybromo	2654..2788	CDD:240068	24/133 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351981
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507784at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850