DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and G9a

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_001259088.1	Gene:	G9a / 30971	FlyBaseID:	FBgn0040372	Length:	1657	Species:	Drosophila melanogaster

Alignment Length:	1821	Identity:	365/1821 - (20%)
Similarity:	596/1821 - (32%)	Gaps:	572/1821 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KHADAEASPTAPEDQDSGQSECRRSSRKKIIKFDVRDLLN---------KNRKAHKI------QI 92
            ||.|.|         :..:.|.|.....:.||..:.|:::         :.:.|.|:      :|
  Fly    56 KHKDKE---------EEERKEARNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEPHTKCEI 111

  Fly    93 E-------------ARIDSNPSTGHSQSG-TTAASTSMSTATASAASASSAATVS------RLFS 137
            |             |:.||...  ..|:| .|:.:..|.:...:...|:..||.|      ..|.
  Fly   112 EEEGRKEMEYDQDVAKQDSEME--KKQNGKATSITVKMESNERAEKHATEIATTSTERWENESFK 174

  Fly   138 MFEMSHQSLPPPPPPPTA----LEIFAKPRPTQSLIVAQVTSEPSAVGGAH-----------PVQ 187
            ..:.:.::......|..|    ||..|:|..|..:.||  .:.|..|..|.           ...
  Fly   175 TEQQNKKAAEKEEEPILAATQKLEANAEPLTTTRIEVA--VASPLVVSSASVKLAADATNQMRAA 237

  Fly   188 TMAGL-----------PPVTPRKRGRPRKSQLADAAIIPTVIVPSCSDSDT---NSTSTTTSNMS 238
            |.||.           |..|.|.|..||          |.....|.:|...   |.....:...:
  Fly   238 TSAGAATLADKNVQVSPGGTRRSRRTPR----------PIDTPTSVTDEHVQVENKKFGKSEQYT 292

  Fly   239 SDSGELPGFPIQKPKSKLRVSLKRLKLGGRLESSDSGNSPSSSSPEVEPPALQDENAMDERPKQE 303
            ..|..|..|.:....:.:|:.||         |.....|.::.|||        ||:. ..||:.
  Fly   293 DCSSHLERFTLDDNTAIVRLQLK---------SEPDKPSLTALSPE--------ENSA-PAPKRG 339

  Fly   304 QNLSRMV--DAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEP---QDLIDIDMELAKQEP 363
            :..:|.:  |||..:   |::|   :..|...||::....|.:..||   |.|.|:.:...:||.
  Fly   340 RGRARKIRPDAEVET---SEVI---LPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQEE 398

  Fly   364 TPD-PEEDL--------------------DEIMVEVLSGPPS--LWSADDEAEEEEDATVQRATP 405
            ..| |..|:                    :|:..|.|...||  |..|:..:|....|.:...||
  Fly   399 LGDAPLGDVKRMRRSVRLGNRLHADGSPWEEVKTEALHPQPSAELSFAEVTSEILPLAVLDEKTP 463

  Fly   406 PGK--EPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSK------QILEAEESQ-D 461
            |.|  ..|...|......:....|.:..:::..:......::...|.:      :|||.:|.: :
  Fly   464 PKKRGRKAKTPCVKLESETSCGLPFANGNKKTNSSGGCELQLPKRSKRRIKPTPKILENDELRCE 528

  Fly   462 QEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQE--------- 517
            .|.:||      :.:::.|..::|....|...........:....::|:...|..|
  Fly   529 FETKHI------ERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPGHPAGT 587

  Fly   518 -FVIKKVFSES----DNI-AASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKS 576
             .:.|::||:|    :|. ||.|.|....|       |.:|    |....|:..:...|....:.
  Fly   588 SAIKKRLFSKSQRDIENYGAAMLAKSKLPP-------CPDV----EQFLNDIKASRINANRSPEE 641

  Fly   577 AVVTKPTTEMIAETK--------LSDEVVIEPPLKDESDPKQ-----TEVELPESKPAVNIPKSE 628
            ..:.|.....:|:.|        |......||...|.|:...     |.|::  .||:|.: :..
  Fly   642 RKLNKKQQRKLAKQKEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPTTRVQV--GKPSVTL-RVR 703

  Fly   629 RILSAEVETTSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPAAPE 693
            ..::.|:.||:         ||:|...||:....|:....:....|.    ||||:...|.:.|:
  Fly   704 NSVTKELPTTA---------TLKSRRNPVVQAAKLTRRIGARAAGEV----TEAARASVPISTPD 755

  Fly   694 EEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSK----KE 754
            .|..:|.:         .|.|..|                ||:.::  ..:|....|||    .:
  Fly   756 AEQLHSLD---------TSIQADV----------------TPIRDL--DMRPSTSRVSKFICLCQ 793

  Fly   755 KAMENPARSSP---------AIVDKKVR-AGEMEKKVVKSTKGT----------VPEKKMDSKKS 799
            |..:..||::|         .|.|:|:. ..|:..:|....:.:          ..:|::.|...
  Fly   794 KPSQYYARNAPDSSYCCAIDHIDDQKIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQSHNC 858

  Fly   800 CAA---------VTPAKQKE--SGKSAKEAILKKETEKE---KSSAKLDSSSPNTLDK---KGKD 847
            ||.         ....||:.  ....|:..||....|||   :....:..|||..:.|   .|.|
  Fly   859 CAGCGIFCTQGKFVLCKQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLD 923

  Fly   848 TAQWSP----QLQTLP------KSSTKPPQESAPSVISK--TTSNQPAPKEEQHAAKKGLSD--- 897
            |.:.:.    :.|:||      |...||.:.:..|.:::  |..|...|..... .|.|||.
  Fly   924 TPERTSTVTMKCQSLPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATAR-NKGGLSTAVT 987

  Fly   898 ----NSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPT 958
                :||.|.....::..:|....::......:..|||            :|..|         .
  Fly   988 LSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQL------------IPESV---------M 1031

  Fly   959 AVPVPGQKKSLSGKTSLR---RNTVYE-DSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPR 1019
            .|.:.|...|.||:.:..   |:..|. .:.:|||
  Fly  1032 NVVLRGHVVSASGRVTAEFTPRDMYYAVQNDDLER------------------------------ 1066

  Fly  1020 RSTICEAAKDLRSSSSSSTPTRE---------VAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKL 1075
                  .|:.|.:..:..||.||         ||.|..:..:.....|...|....:.:|    .
  Fly  1067 ------VAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKGASSPDFVNIVD----Y 1121

  Fly  1076 DQRRYTICEDRQ-------------PETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGR- 1126
            :.|...:|....             .:.||..|..|.  |:|..|....|..|.|.....:..|
  Fly  1122 ELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKT--SLHIAAQLGNLEATQLIVDSYRTSRN 1184

  Fly  1127 -----------------------KEGKESLSRQNSLDSSSSASQGAPKKKALKSAEI-LSAALLE 1167
                                   :.|...:.|..||          |:...||...| |..:.|.
  Fly  1185 ITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASL----------PQAVFLKLINIFLFISFLL 1239

  Fly  1168 TESSEST---SSGSKMSRWD-------------VQTSPELEAANPFGD----IA----------K 1202
            .:.::..   :..:.:..|.             :|:..:....|..||    ||          .
  Fly  1240 NQDADPNICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIA 1304

  Fly  1203 FIEDGVNLLKRDKVDEDQRKEGQDEVKREADP-EEDEFAQRVA-NMETPATTPTPSPTQSNPEDS 1265
            .|.:|.:|:.::|.         :::..:..| ||.|..:.|. ||:
  Fly  1305 LIANGADLMIKNKA---------EQLPFDCIPNEESECGRTVGFNMQ------------------ 1342

  Fly  1266 ASTTTVLKELETGGGVRRSHRIKQKPQGPR-------ASQGRGVASVALAPISMDEQLAELANIE 1323
                            .||.|    |.|.|       ||.||                 |...|:
  Fly  1343 ----------------MRSFR----PLGLRTFVVCADASNGR-----------------EARPIQ 1370

  Fly  1324 AINEQFLRSEGLN-------------TFQLLKENFYRCARQVSQEN--------AEMQCDCFLTG 1367
            .:..:...||..:             |..::::|..:..|:|||..        :..:|.|....
  Fly  1371 VVRNELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSCSSDRCQCNGAS 1435

  Fly  1368 DEE---AQGHLSCGAGCINRMLMIECGPLCS-NGARCTNKRFQQHQCWPCRVFRTE--KKGCGIT 1426
            .:.   |:..|:......:..::.||..:|. |...|.|:..|.....|.::...|  .||.|:.
  Fly  1436 SQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVR 1500

  Fly  1427 AELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHS 1491
            |...:|.|.|:..|.||::.:.|.:||       .:..|||....|.. |||...||::|:.|||
  Fly  1501 ALANVPKGTFVGSYTGEILTAMEADRR-------TDDSYYFDLDNGHC-IDANYYGNVTRFFNHS 1557

  Fly  1492 CDPNA-------ETQKWTVNGELRIGFFSVKPIQPGEEITFDY--QYLRY-GRDAQRCYCEAANC 1546
            |:||.       |.|.:...   :|.|||.:.|..||||.|||  ::.|. .|....|.|....|
  Fly  1558 CEPNVLPVRVFYEHQDYRFP---KIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTC 1619

  Fly  1547 R 1547
            :
  Fly  1620 K 1620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	11/55 (20%)
		SET	1414..1533	CDD:214614	45/130 (35%)
		PostSET	1535..1551	CDD:214703	3/13 (23%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
G9a	NP_001259088.1	ATP-synt_B	150..248	CDD:304375	20/99 (20%)
		Ank_2	1056..1152	CDD:289560	19/135 (14%)
		ANK	1088..1217	CDD:238125	20/134 (15%)
		ANK repeat	1088..1120	CDD:293786	5/31 (16%)
		ANK repeat	1124..1153	CDD:293786	4/28 (14%)
		Ank_2	1127..1249	CDD:289560	22/133 (17%)
		ANK	1155..1306	CDD:238125	25/162 (15%)
		ANK repeat	1155..1196	CDD:293786	8/42 (19%)
		ANK repeat	1199..1249	CDD:293786	10/59 (17%)
		Ank_2	1205..1316	CDD:289560	20/120 (17%)
		ANK repeat	1251..1283	CDD:293786	2/31 (6%)
		ANK repeat	1285..1316	CDD:293786	7/30 (23%)
		PreSET	1357..1466	CDD:128744	20/125 (16%)
		SET	1495..1602	CDD:214614	43/117 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467626
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840