Protein Alignment Set2 and Nsd1

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_001388465.1
• Gene: Nsd1 / 306764
• RGDID: 1307748
• Length: 2689
• Species: Rattus norvegicus
• Alignment Length: 2897
• Identity: 551/2897 - (19%)
• Similarity: 906/2897 - (31%)
• Gaps: 1061/2897 - (36%)

  Fly    11 SPVASRGRGRGRPPKVALS--ALGNTPPHINPSL-------------------KHADAEASPTAP 54
            ||:.......|.|..:|::  ...|.||.:..|:                   ...|:|..|..|
  Rat   109 SPIVCTSLSPGGPTALAMNQEPTCNNPPELQLSVTKTTKNGFLHFDNFTCVDDADVDSEMDPEQP 173

  Fly    55 EDQDSGQSEC-RRSSRKKIIKFDVRDLLNKNRKAHKIQIEARIDSNPSTGH-------------- 104
            ..:|....|. ..:.......::     .|:....::.:.:..||.|.:.|
  Rat   174 VTEDESIEEIFEETQTNASCNYE-----PKSENGVEMAMGSEQDSMPESRHGAVEQPFVPLAPQT 233

  Fly   105 ------SQSGTTAASTSMSTATASAASASSAATVSRLFSMFEMSHQSLPPPPPPPTALEIFAKPR 163
                  .:|....::...:...|..:...:..|:...|:...:|.|..|.           :...
  Rat   234 EKQKNKQRSEVDGSNEKTALLPAPNSLGDTNVTIEEQFNSINLSFQDDPD-----------SSTS 287

  Fly   164 PTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAAII----------PTVI 218
            ...:::....||.||         |...||...|:|:..|.|.::.|  :|          |..|
  Rat   288 TLGNMLELPGTSSPS---------TSQELPFCHPKKKSTPLKYEVGD--LIWAKFKRRPWWPCRI 341

  Fly   219 VPSCSDS--DTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRL----------------KL 265
               |||.  :|:|.....:........:..|  ..|..|..|:.|.:                |.
  Rat   342 ---CSDPLINTHSKMKVANRRPYREYYVEAF--GDPSEKAWVAGKAIVMFEGRHQFEELPVLRKR 401

  Fly   266 GGRLESSDSGNSPSSSSPEVEPP-ALQDENAMDERPKQEQNL--SRMVDAEEN-------SDSDS 320
            |.:.|.......|.....:.|.. .|.::..:...||.::.:  |..:|:||:       :|.||
  Rat   402 GKQKEKGYRHKVPQKILSKWEASVGLAEQCDVPRGPKTQKCVPSSAKLDSEEDMPFEDCANDPDS 466

  Fly   321 Q--------IIFIEIETESPKGEEEQEEGRPVEVEPQDLID--------IDMELAKQEPTPDPEE 369
            :        :..:..::|....|:|:...:....:..|.|.        :..|..|:|......|
  Rat   467 EHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRVRKSSDNIKRTSVKKGLMPFEAQKEERRGKSPE 531

  Fly   370 DLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPG----------------KEPAADSCSSA 418
            :|.   ::.|||..|...|.:|.....::....:..||                :.|..||.|..
  Rat   532 NLG---LDFLSGGVSDKQASNELSRIANSLTGSSAAPGQFLFSSCGQNTAKTDFETPNCDSLSGL 593

  Fly   419 PRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLSESEVTS 483
                ..||.:|..|.:.|.|:.  .::.  |||..|....:.|:|::.   |.:....:..:.:|
  Rat   594 ----SESALISKHSGEKKKLQP--GQVC--SSKVQLCYVGAGDEEKRS---DSVSVCTTSDDGSS 647

  Fly   484 SVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETKAT 548
            .:.||..:....:.|:|....:|:.:.                    |.|::|:      |||.:
  Rat   648 DLDPTEHNSEFHKSVLEVTDALDKTEN--------------------ALSMHKN------ETKYS 686

  Fly   549 CGEVVPRPEMVTE--DVYITEGIAATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDESD---- 607
               ..|....|.|  ...||......|..|....:|.|..|::..|||..:..|..|.:.:
  Rat   687 ---RYPATNRVKEKQKSLITNSHTDHLMDSTKTVEPGTAEISQVNLSDLKISSPIPKPQPEFRND 748

  Fly   608 -----------------------PKQTEVELPESKP---AVNIPKSERILSAEVETTSSPLVPPE 646
                                   ..||.:.|...:|   ::.....|...:||...||..| ..:
  Rat   749 GLTTKFNAPPGIRNENSLTKGGLANQTLLPLKCRQPKFRSIKCKHKESPTAAETSATSEDL-SLK 812

  Fly   647 CCTLESVSGPVLLETSLSTEEK---------------SNENVETTPLK----------TEAAKED 686
            ||:.::...|:   ||:|...|               .:.::||..:|          ..:..||
  Rat   813 CCSSDTNGSPM---TSISKSGKGEGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLSED 874

  Fly   687 ------SPPAAPEEEASNSSE-----EPNF-------LLEDYESNQEQVAEDEMMKCNN------ 727
                  |..:.|...:|.||:     ||::       :|:|...::.:  |..:|...|
  Rat   875 VSDSGTSKSSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTK--EQRLMTAQNVASYRT 937

  Fly   728 -QKGQKQTPLP-----------EMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKK 780
             .:|...:..|           .....|||...|        ::..|.||...|..: :||:
  Rat   938 PDRGDCSSGSPVGTSKVLVLGGSTHNSEKPGDST--------QDSVRLSPGGGDSAL-SGEL--- 990

  Fly   781 VVKSTKGTVPEKKMD------------SKKSC--AAVTP-AKQKESGKSAKEAILKK--ETEKEK 828
              .|:...:|..|.|            .:::|  |.::| .:...|.:.||.::..|  :||:::
  Rat   991 --SSSLSVLPSDKRDLPACGKIRSNCIPRRNCGRAKLSPKLRVTISTQMAKPSVNPKALKTERKR 1053

  Fly   829 SSAKLD--SSSPNTLDKK-------------GKDTAQWSP--QLQTLPKSST----KPPQESAPS 872
            ..::|.  :.:.|.|..|             .:|.|:..|  |:..|....|    |..|.....
  Rat  1054 KLSRLPAVTLAANGLGNKESGGSVNGPLKGGAQDPAKEEPLQQMDLLRNEETHFDSKVKQSDPDK 1118

  Fly   873 VISKTTS-----------------------------------NQPAPKEEQHAAK---------- 892
            ::.|..|                                   ||..||..:.|::
  Rat  1119 ILEKEPSFENRKGPEVGSEINIENDEPHGVDQVVPKKRWQRLNQRRPKPGKRASRFREKENSEGA 1183

  Fly   893 -----------KG----LSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLK 942
                       ||    |...:||:.:.....|....|      ...:....:|.:.:|:...:.
  Rat  1184 FGVLLPGDPVQKGRDDYLEQRAPPTSILEDSAADPNHV------SHSESVGPRLNVCDKSSVSMG 1242

  Fly   943 KVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNT--VYEDSPNLERNSSPSSDSAQANTSAG 1005
            .: .|....|.:.|.|.:|.|..:   |.|..||:.:  :.|.:...::..:|
  Rat  1243 DL-EKETGIPSLTPQTKIPEPAVR---SEKKRLRKPSKWLLEYTEEYDQIFAP------------ 1291

  Fly  1006 KLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLD 1070
            |.|..||::::: :.|:.|| .:.|.:...||...::|..:|.:||..:...    .:|....|:
  Rat  1292 KKKQKKVQEQVH-KVSSRCE-DESLLARCRSSAQNKQVDENSLISTKEEPPV----LEREAPFLE 1350

  Fly  1071 GGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPL---HDTLLQTAGKKRGRKEGK-- 1130
            |  .|.|....:.....|:..:.||:.       |:.|..|.   .:.|::|.|...|:::.|
  Rat  1351 G--PLVQSDLGVAHAELPQLTLSVPVA-------PEVSPRPTLESEELLVKTPGNYEGKRQRKPT 1406

  Fly  1131 ESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAAN 1195
            :.|...|.||...     .|||..|.    ||....|:...|:...       |.:.:|.|:
  Rat  1407 KKLLESNDLDPGF-----MPKKGDLG----LSRKCCESGHLENGVG-------DSRATPHLK--- 1452

  Fly  1196 PFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANMETPA---------- 1250
            .||.....|.|.....||       ::.|...|..:...:||      :..|||:
  Rat  1453 EFGGGTTRIFDKPRKRKR-------QRHGTARVHYKRVKKED------SARETPSSAEGELMIHR 1504

  Fly  1251 TTPTPSP-----TQSNPEDSASTTTVLKEL--ETGGGVRRSHRIKQK------------------ 1290
            |..:|..     .:.:|..|||     |.|  |.|||......:.|.
  Rat  1505 TAASPKEILEEGIEHDPGMSAS-----KRLQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAF 1564

  Fly  1291 ----------PQG---------------------------------------------PRASQGR 1300
                      |:|                                             |...|.:
  Rat  1565 HLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVVQNK 1629

  Fly  1301 GVASVALAP--ISMDEQLAELANIEAINEQFLR------SEGLNTF------QLLKENFYRCARQ 1351
            |..    .|  |.:....|..||:.|...:.:|      :...|.|      ::|..|...|...
  Rat  1630 GFR----CPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNH 1690

  Fly  1352 -------------------VSQENAEMQC-------------------------DC--------- 1363
                               |..|...:.|                         ||
  Rat  1691 FTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYR 1755

  Fly  1364 ---------------------------------------------------------FLTGD--- 1368
                                                                     ::.||
  Rat  1756 EIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSS 1820

  Fly  1369 -----------------------EE--AQGHL--------------------------------- 1375
                                   ||  ||..|
  Rat  1821 KDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTA 1885

  Fly  1376 ----------------SCG--AGCINRMLMIECGP-LCSNGARCTNKRFQQHQCWPCRVFRTEKK 1421
                            .||  :.||||||:.||.| :|..|.||.|:.|.:.|.....:|||.::
  Rat  1886 DLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPDVEIFRTLQR 1950

  Fly  1422 GCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISR 1486
            |.|:..:..|..|||:.|||||:||.||...|.....:....::|.:.|..:.:|||..|||.:|
  Rat  1951 GWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYAR 2015

  Fly  1487 YINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIG 1551
            ::||.|.||.|||||:|||:.|:|.|::..|:.|.|:||:|.....|.....|.|.|.||.|::|
  Rat  2016 FMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLG 2080

  Fly  1552 GEPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQP----RKSAKAKAKSKLKAKLPLATGRKRKE 1612
            ..|                            :.||    .||.|.|.|       |....|.:.|
  Rat  2081 VRP----------------------------KNQPIVTEEKSRKFKRK-------PHGKRRSQGE 2110

  Fly  1613 QTKPKDRE-YKAGRWLKPSATGSSSSAEKPPKKPKVNKFQAMLEDPDVVEELSLLRRGGLKNQQD 1676
            .||.::.| :..|       .|....:.|.|..|||  :.|        :.|:|.:|...|.:
  Rat  2111 VTKEREDECFSCG-------DGGQLVSCKKPGCPKV--YHA--------DCLNLTKRPAGKWE-- 2156

  Fly  1677 TLRFSRCLVRAKLLKTRLALLRVLTHGELPCRRLFLDYHG-----LRLLHAWISENGND------ 1730
             ..:.:|.|..|         ...:..|: |...|...|.     :..|...:|...:|
  Rat  2157 -CPWHQCDVCGK---------EAASFCEM-CPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNP 2210

  Fly  1731 ---DQLREALLDTLESLPIPNRTMLSDSRVYQSVQLWSNSLEQQLAVVPQE---------KQAAL 1783
               .::||.:..|....|.|     ...:..||.::.:..        |::         :..:|
  Rat  2211 LEPGEIREYVPPTATLSPSP-----GTQQTEQSSEMGTQG--------PKKSDQPPTDATQMLSL 2262

  Fly  1784 HKRMVALLQKWQALPEIFRIPKRERIEQMKEHEREADRQQKHVHASTALEDQRERESSN---DRF 1845
            .|:.|....:...|||  |.|:|                               .:||:   ||.
  Rat  2263 SKKAVTGTCQRPLLPE--RPPER-------------------------------TDSSSHLLDRI 2294

  Fly  1846 RQDRFRRDTTSSRIGKPIRMSGNNTIC-TITTQQKGSNGAP--DGMTRNDNRRRSDIGPPSEQRR 1907
            |.                 ::|:.|.. ::.:.|:..:..|  :|.......|.|.:..||....
  Rat  2295 RD-----------------LAGSGTKSQSLVSSQRPQDRPPAKEGPRPQPPDRASPVTRPSSSPS 2342

  Fly  1908 TLSKELRRSLFERKVALDEAERRVCTEDRLEHELRCEFFGADINTDPKQLPFYQKTDTNEWFNSD 1972
            ..|..|.|.|            |: ||.||:..:     ||   ..||               |.
  Rat  2343 VSSLPLERPL------------RM-TEPRLDKSI-----GA---ASPK---------------SQ 2371

  Fly  1973 DVPVPAPPRTELLTKALLSPDIDVGQGATDVEYKLPPGVDPLPPAWNWQVTSDGDIYYYNLRERI 2037
            .|..|..| |.|   .|.|||..:...:.      .|.:...||          |..:.:|.:|:
  Rat  2372 AVEKPPAP-TGL---RLSSPDRLLNTNSP------KPQISDRPP----------DKSHASLTQRL 2416

  Fly  2038 SQWEPPSPEQRLQTLLEENTTQQPLHELQIDPAVLENELIQVDTDYVGSLSAKSLAQYIEAKVRE 2102
                 |.||:.|..:::....:             |..|..||.:        :.|::..|.|.:
  Rat  2417 -----PPPEKVLSAVVQSLVAK-------------EKALRPVDQN--------TQAKHRAAVVMD 2455

  Fly  2103 RRDLRRSKLVSIRLISPRRDEDRLYNQLESRKYKENKEKIRRRKELYRRRKIEVLPDAVDEIPVP 2167
            ..||           :||:.| |..:..|.....:.|..:.........|.:..:|.||::   .
  Rat  2456 LIDL-----------TPRQKE-RAASPQEVTAQADEKTPVLESSSRPTSRGLGHVPRAVEK---G 2505

  Fly  2168 GKALPIQPYLFSSDEEETKVAAIEQPAAEEEQDSLNMAPSTSHA-------AMAALGKAVAQPTG 2225
            |.:.|:||...|:...|....|::               |.:||       |.|.|.::..|.:|
  Rat  2506 GVSDPLQPPGKSAAPSEHPWQAVK---------------SLTHARFLSPPSAKAFLYESAIQASG 2555

  Fly  2226 LGTVGKRKLPMPPSVT---VKKHRQEQRSKKVKSSQS 2259
            ...||..:.|.|||..   :|:.:|..|....||.||
  Rat  2556 RAPVGSEQTPGPPSPAPGLLKQVKQLSRGLTAKSGQS 2592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	29/157 (18%)
		AWS	1358..1410	CDD:197795	27/222 (12%)
		SET_SETD2	1410..1551	CDD:380949	57/140 (41%)
		WW	2014..2043	CDD:459800	5/28 (18%)
		SRI	2266..2355	CDD:462404
Nsd1	NP_001388465.1	PWWP_NSD1_rpt1	318..433	CDD:438989	22/121 (18%)
		TNG2	<1452..1585	CDD:227367	28/153 (18%)
		PHD1_NSD1_2	1543..1585	CDD:277118	3/41 (7%)
		PHD2_NSD1	1590..1636	CDD:277120	4/49 (8%)
		PHD3_NSD1	1637..1690	CDD:277123	11/52 (21%)
		PHD4_NSD1	1707..1746	CDD:277126	3/38 (8%)
		PWWP_NSD1_rpt2	1753..1848	CDD:438992	4/94 (4%)
		AWS	1899..1937	CDD:465559	17/37 (46%)
		SET_NSD1	1939..2080	CDD:380987	57/140 (41%)
		PHD5_NSD1	2118..2160	CDD:277129	13/61 (21%)
		C5HCH	2159..2208	CDD:465605	10/58 (17%)
		PHA03247	<2221..2593	CDD:223021	109/547 (20%)