DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Set2 and Ezh1

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_001100521.1	Gene:	Ezh1 / 303547	RGDID:	1305028	Length:	747	Species:	Rattus norvegicus

Alignment Length:	749	Identity:	164/749 - (21%)
Similarity:	242/749 - (32%)	Gaps:	258/749 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   880 NQPAPKEEQ--HAAKKGLSDNSP---PSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKK 939
            ||.:.:||:  :....|..|:|.   |...|.|..|:.|                       |||
  Rat   184 NQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEG-----------------------NKK 225

  Fly   940 KLKK-VPTKV--EAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQAN 1001
            ..|| .|..:  .|...:.|...||.       ..|...|..|...|...|....:|:.|...|
  Rat   226 SSKKQFPNDMIFSAIASMFPENGVPD-------DMKERYRELTEMSDPNALPPQCTPNIDGPNA- 282

  Fly  1002 TSAGKLKPSKVKKKINPRRSTICEAA--KDLRSSSSSSTP------TREVAASSPVSTSSDSSSK 1058
                  |..:.::.::...:..|...  .|.......:||      .||:.. .|....:|....
  Rat   283 ------KSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNVYKRKNREIKI-EPEPCGADCFLW 340

  Fly  1059 RNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASA---NPLHDTLLQTA 1120
            ..|:|......:..||...||                  :||   ||..||   |.....:.:|
  Rat   341 LEGAKEYAMLHNPRSKCSGRR------------------RRR---HPVVSASCSNTSASAMAET- 383

  Fly  1121 GKKRGRKEGKESLSRQNSLDSSSSAS----QGAPKKKALKSAEILSAALLETESSESTSSGSKMS 1181
                  |||.......|...||||.:    |...|:||..:...|......:|..|.|.:...:.
  Rat   384 ------KEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLF 442

  Fly  1182 RWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANM 1246
            |....|     ..|.|..||:.:  |....|                      :..:||.:.:.:
  Rat   443 RVFHGT-----YFNNFCSIARLL--GTKTCK----------------------QVFQFAVKESLI 478

  Fly  1247 ETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPIS 1311
            ....|....:|:|..                    :|.||:
  Rat   479 LKLPTDELMNPSQKK--------------------KRKHRL------------------------ 499

  Fly  1312 MDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCD----CFLTGDEEAQ 1372
               ..|....|:      |:.:. |:.|:.  |:..|      ::.:..||    |.:|.:
  Rat   500 ---WAAHCRKIQ------LKKDN-NSTQVY--NYQPC------DHPDRPCDSTCPCIMTQN---- 542

  Fly  1373 GHLSCGAGCINRMLMIECGPLCSN---GARC-TNKRFQQHQC--------------------WPC 1413
               .|...|       :|.|.|.|   |.|| |....:|..|                    |.|
  Rat   543 ---FCEKFC-------QCSPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDC 597

  Fly  1414 RVFRTEKKGC----GITAELLIPP----------------GEFIMEYVGEVIDSEEFERRQHLYS 1458
            :|  ...|.|    |:...||:.|                .|||.||.||:|..:|.:||..:|
  Rat   598 KV--VSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVY- 659

  Fly  1459 KDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEI 1523
             |:....:...|..:.|:|||.|||..|:.|||.:||...:...|||:.|||.|:.:.||.|||:
  Rat   660 -DKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEEL 723

  Fly  1524 TFDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSD 1557
            .|||:|            ..|:...::|.|.::|
  Rat   724 FFDYRY------------SQADALKYVGIERETD 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	15/59 (25%)
		SET	1414..1533	CDD:214614	50/138 (36%)
		PostSET	1535..1551	CDD:214703	1/15 (7%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Ezh1	NP_001100521.1	EZH2_WD-Binding	39..68	CDD:402972
		PRC2_HTH_1	159..262	CDD:407952	24/107 (22%)
		SANT	433..474	CDD:238096	12/69 (17%)
		SET	<463..727	CDD:225491	81/365 (22%)
		SET_EZH1	608..743	CDD:380994	50/148 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352018
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840