Protein Alignment Set2 and Nsd3

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_038950324.1
• Gene: Nsd3 / 290831
• RGDID: 1308980
• Length: 1444
• Species: Rattus norvegicus
• Alignment Length: 1477
• Identity: 304/1477 - (20%)
• Similarity: 480/1477 - (32%)
• Gaps: 537/1477 - (36%)

  Fly   493 VVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETKATCGEVVPRPE 557
            ::...:.:..||:|.|    :.:||    ..|..:.:|........||..::....|       .
  Rat    11 IMGNTIQQPPQLIDSA----NIRQE----DAFDNNSDIVEDGGPTPFEATLQQGFQC-------P 60

  Fly   558 MVTEDV-YITEGIAATLEKSAVVTK----------------------PTT---EMIAETKLSDEV 596
            ..|||: .:|.|...::......||                      ||.   ..|..|:..:
  Rat    61 PATEDLPPLTNGYPPSISLYETQTKYPPYSQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHE-- 123

  Fly   597 VIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLET 661
            ::|.|...:..|.......|...|...|||.          |.||.:..: .|....:|..|.|:
  Rat   124 ILEKPSPPQPPPPPLLPPPPPPVPQTVIPKK----------TGSPEIKLK-ITKTIQNGRELFES 177

  Fly   662 SLS----TEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEM 722
            ||.    .|.:::|::::   |.|:.||....:: ..|:|.|.|..:..:...|...:
  Rat   178 SLCGDLLNEVQASEHLKS---KHESRKEKRKKSS-RHESSRSEERKSHKVPKLEPEGQ------- 231

  Fly   723 MKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDK----KVRAGEMEKKVVK 783
                |:..::..|.|| |..|:||.     ||.....|..||....:.    |.:.|::    |.
  Rat   232 ----NRPNERVDPAPE-KPREEPVL-----KEAVPVQPILSSVPTTETSTGVKFQVGDL----VW 282

  Fly   784 STKGTVP-----------------------------------------EKKMDSKKSC----AAV 803
            |..||.|                                         ||::...|..    ..:
  Rat   283 SKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHEQYEELL 347

  Fly   804 TPAKQKESGKSAKEAILKKETEKEKSS----------------------------AKLDSSSPNT 840
            ..|.::.|..|.|:.|.|...::|::.                            .|....||:.
  Rat   348 AEAAKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALQMTREERVEQYTFIYIDKQPEESPSQ 412

  Fly   841 LDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLK 905
            ..|.....|:.....:.....:::|.|.||..|.|..:|..  |:.:.......:.::.||.|..
  Rat   413 AKKSVTSKAEVKKPRRPRSVGNSQPEQTSAGEVASPQSSTD--PRRQSQRRHTSVEEDGPPPVKI 475

  Fly   906 AKEKA-----------------------VSGFVECDAMFKAMDLANA------------------ 929
            |...|                       :|..|:.:.:|.   |.||
  Rat   476 AWRTAAARKSLPASITMHKGSLDLHKCNMSPVVKIEQVFA---LQNATGDGKFIDQFVYSTKGIG 537

  Fly   930 -----------QLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPV--PGQKKSLS----------- 970
                       :|.:...:::..|..|:  .:||:....:|.||  ..|::|:.
  Rat   538 NKTEISVRGQDRLIISSPSQRNEKSTPS--ASPPEATSGSAGPVEKKQQRRSIRTRSESEKSTEV 600

  Fly   971 -GKTSLRRNTVYEDSP------NLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAA- 1027
             .|..:::....|.||      .|::.:|..|||.         ||.|.:.    |.||..|.|
  Rat   601 VSKKKIKKEQQVETSPQASLKTGLQKGASEISDSC---------KPLKKRS----RASTDVETAS 652

  Fly  1028 ---KDLRSSSSS-------------STPTREVAASSPVSTSSDSSSKRNGSKRTTSDL------D 1070
               :|...|.|.             .:|:....|.:..:.|.|||..|.|...:..|.      :
  Rat   653 CTYRDTSDSDSRGPSDGQVGFGKQVDSPSAAADADASDAQSVDSSLSRRGVGLSKKDTVCQVCEN 717

  Fly  1071 GGSKLDQRRYTICEDRQPE----TAIPVPLTKRRFS-------MHP----KASANPLHDTLLQTA 1120
            .|..|.......|....||    .|:|    :.||:       .||    |.|...:....:...
  Rat   718 TGDSLVACEGECCRHFHPECLGLAAVP----EGRFTCEECETGQHPCFSCKVSGKDVKRCSVSVC 778

  Fly  1121 GK----KRGRK------EGKESLSRQNSLDSSS------SASQGAPKK--------------KAL 1155
            ||    ...||      |.|.....|:...|.|      .||:|...|              .|.
  Rat   779 GKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKGRMMKCLRCPIAYHFGDACVAA 843

  Fly  1156 KSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVN-----LLKRDK 1215
            .|..:.|..|:.:..|:.:|..:                            .:|     :..|..
  Rat   844 GSVSVSSHILICSNHSKRSSHSA----------------------------AINVGFCFVCARGL 880

  Fly  1216 VDEDQRKEGQDEVKREADPEEDEFA----------QRVANMETPATTPTPSPTQSNPEDSASTTT 1270
            :.:|           .:||....:|          .|...|:.|..          |..|||.
  Rat   881 IVQD-----------HSDPMFSSYAYKSHYLLSESNRAELMKLPMI----------PSSSASK-- 922

  Fly  1271 VLKELETGGGV--------------------------------RRSHRIKQ-------------- 1289
              |..|.||.:                                ::.| .||
  Rat   923 --KRCEKGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLH-YKQIVWVKLGNYRWWPA 984

  Fly  1290 KPQGPRA----------------------------SQGRGVASVALAPISMDEQLAELANIEAIN 1326
            :...||:                            .|||     ....:..|...||  ...:||
  Rat   985 ETCSPRSVPLNIQGLKHGVGDFPVLFFGSHDYYWVHQGR-----VFPYVEGDTNFAE--GQTSIN 1042

  Fly  1327 EQFLRS--EGLNTFQLLKENFYRCARQVSQENAEMQ----------------------------- 1360
            :.|.::  |....||.||      |::.|:|..|::
  Rat  1043 KTFKKALEEAAKRFQELK------AQRESKEALEIEKTSRKPPPYKHIKANKVIGKVQIQVADLS 1101

  Fly  1361 ----CDCFLTGDEEAQGHLSCG--AGCINRMLMIECGP-LCSNGARCTNKRFQQHQCWPCRVFRT 1418
                |:| ..|||.     .||  :.|:|||...||.| :|..|.||.|:.|.:.......:.:|
  Rat  1102 EIPRCNC-KPGDEN-----PCGLESECLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKT 1160

  Fly  1419 EKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGN 1483
            |::|.|:..:..|..|||:.|||||:||.||...|.....::...::|.:.:..:.:|||..|||
  Rat  1161 ERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGN 1225

  Fly  1484 ISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRG 1548
            .||::||||:||.|||||||||::|:|.|::..|..|.|:||:|.....|.....|:|.|.||.|
  Rat  1226 YSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTVCHCGADNCSG 1290

  Fly  1549 WIGGEPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAK 1595
            ::|..|.|......||:: .:|::            :.|:..||:||
  Rat  1291 FLGVRPKSACTSAADEKT-KNAKL------------KKRRRGKAEAK 1324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	31/199 (16%)
		AWS	1358..1410	CDD:197795	21/87 (24%)
		SET_SETD2	1410..1551	CDD:380949	58/140 (41%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
Nsd3	XP_038950324.1	PWWP_NSD3_rpt1	275..404	CDD:438991	16/132 (12%)
		PHD1_NSD3	711..753	CDD:277119	9/45 (20%)
		PHD2_NSD3	759..805	CDD:277122	9/45 (20%)
		PHD_SF	806..858	CDD:473978	10/51 (20%)
		PHD4_NSD3	925..960	CDD:277128	3/34 (9%)
		PWWP_NSD3_rpt2	967..1061	CDD:438994	19/107 (18%)
		AWS	1112..1150	CDD:465559	17/42 (40%)
		SET_NSD3	1152..1293	CDD:380989	58/140 (41%)
		PHD5_NSD3	1330..1372	CDD:277131
		C5HCH	1371..1420	CDD:465605