Protein Alignment Set2 and lin-59

DIOPT Version :9

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_491206.1
• Gene: lin-59 / 266825
• WormBaseID: WBGene00003040
• Length: 1312
• Species: Caenorhabditis elegans
• Alignment Length: 1072
• Identity: 210/1072 - (19%)
• Similarity: 359/1072 - (33%)
• Gaps: 322/1072 - (30%)

  Fly   745 PVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQK 809
            ||....|.:...|..|:.:.|           |......:|....|:..:.|      |..:...
 Worm   140 PVLNMQSNQNWYMNQPSGTVP-----------MSSNAPATTSSATPDSGIQS------VPTSPPS 187

  Fly   810 ESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLP-KSSTKPPQESAPSV 873
            .|.....:..:....::|......|.:....|....:|     .....:| .|...||..|.|::
 Worm   188 PSYAMMNDVDIGDHDDEEDDDGPADFTDMPLLKPVDED-----DDCYDVPCTSEGPPPNNSNPAI 247

  Fly   874 ISKTTS-NQPAPKEEQHAAKKGLSDNSPPSVLKA----KEKAVSGFVECD-AMFKAMDLANAQLR 932
            .:..:| :.|||.:|  :...|::.....|.|.|    :|:.|...:..| .|.||:.:...:|.
 Worm   248 TTIPSSCSTPAPPKE--SLPTGMNVEEWGSFLIASNMDREEIVRRLMAHDPEMAKAIAMRIRELS 310

  Fly   933 LDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDS 997
            .:|..|||      .:||......||   .|..:.:.:......|:|   :||::..::.|...|
 Worm   311 AEESKKKK------DMEAEVSSTTPT---TPRARGTRTRNKCATRST---NSPDVTTSNLPEEPS 363

  Fly   998 ------AQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSS 1056
                  .:.|....|::..:..:|...||....|:.:||                       :|.
 Worm   364 TSTMGLVKENEDVEKVEGKRRGRKPKKRRGFHKESFEDL-----------------------ESD 405

  Fly  1057 SKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAG 1121
            :|::.:::....|...|         |..| ||:.||.|:...:|.:
 Worm   406 AKKSKAEQHEDHLPEAS---------CSSR-PESVIPPPVDPIQFRL------------------ 442

  Fly  1122 KKRGRKEGK-ESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWDV 1185
            |.|...|.| |.|:::.|.|.:.           |:.:.:.|:.::..|..:...|..:...
 Worm   443 KVREMMERKLEQLTQKMSEDMTE-----------LRLSHLTSSKMVNGERGKRRESFLRQLN--- 493

  Fly  1186 QTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANMETPA 1250
            :.|.:|......|.         ..|:....:.|..:|.:|.:|:|...|.
 Worm   494 EQSKKLRKGGMLGR---------KRLRMFMTESDILEENKDNIKKEVKEES-------------- 535

  Fly  1251 TTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPISMDEQ 1315
               ||.||:                                     .:||       .|.....:
 Worm   536 ---TPPPTK-------------------------------------LRGR-------LPSRRTRE 553

  Fly  1316 LAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQEN--------AEMQCDCFLTGDEEAQ 1372
            .:|:.|.|.:.::|            ...::...:.|...:        ..:.|.|       .:
 Worm   554 PSEIVNPEPVEKKF------------NGEYFEITKSVPSSDDIIPLWMAPSLTCGC-------TK 599

  Fly  1373 GHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWP--C--------RVFRTEKKGCGITA 1427
            |..:....|:||.|.::|...|| ...|:|:||.:..|..  |        ||.:|
 Worm   600 GACTSDMDCLNRALRVQCSSDCS-VPYCSNRRFWKEDCGNKLCVSNGPRSKRVLKT--------- 654

  Fly  1428 ELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSC 1492
            ::....|||:.||.||||..|:   .|..:::||:..  .:|:.....:|||.:.||:|:|.|||
 Worm   655 KIARRAGEFLCEYAGEVITREQ---AQEKFAQDRDPR--IIAIAAHLFVDATKRSNIARFIKHSC 714

  Fly  1493 DPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANC----RG--WIG 1551
            .||:..:.|:|||..|.|.|::..:.|..|||.|...|.....|  |.|.|..|    ||  |..
 Worm   715 KPNSRLEVWSVNGFYRAGVFALSDLNPNAEITVDKSDLLPFDMA--CNCGATECKRVIRGVRWRC 777

  Fly  1552 GEPDS----------DEGEQLDEESDS------DAEMDEEELEAEPEEGQPRKSAKAKAKSKLKA 1600
            .:|:.          :..:.::..|.|      ...|||                .:..:.|:|.
 Worm   778 ADPNEKIVTRRFVIRNRRKTIERSSHSGLPAILQTPMDE----------------NSSIRLKMKQ 826

  Fly  1601 KLPLATGRKRKEQTKPKDREYKAGRWLKPSATGSSSSAEKPPKKPKVNKFQAMLEDPDVVEELSL 1665
            .|.....|.||                   ..||.|....|.....:...:....:|:.||.:||
 Worm   827 VLAAFAFRVRK-------------------IDGSMSRTMLPHYTLIIKFLKTKGNNPNPVEFVSL 872

  Fly  1666 LRRGGLKNQQDTLRFSRCLVRAKLLKTRLALLRVLTHGELPCRRLFLDYHGLRLLHAWI-SENGN 1729
            .|:.......|.|              ..|.:.:.:|           |....:|.:.: |:...
 Worm   873 FRKWLEAIDDDDL--------------ERAFVAIESH-----------YMSSSILSSSLQSKKAK 912

  Fly  1730 DDQLREALLDTLESLPIPNRTMLSDSRVYQSV 1761
            |:..|...|.|....|:|::...:|....:|:
 Worm   913 DNAPRARALSTSCPSPVPSKRGDADLSYLESL 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	14/51 (27%)
		SET	1414..1533	CDD:214614	42/118 (36%)
		PostSET	1535..1551	CDD:214703	8/21 (38%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
lin-59	NP_491206.1	AWS	591..636	CDD:197795	14/52 (27%)
		SET	638..748	CDD:214614	41/123 (33%)
		PHD	970..1027	CDD:279022
		BAH_polybromo	1118..1222	CDD:240068

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040