Protein Alignment Set2 and Setbp1

DIOPT Version :9

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_444329.2
• Gene: Setbp1 / 240427
• MGIID: 1933199
• Length: 1582
• Species: Mus musculus
• Alignment Length: 1946
• Identity: 366/1946 - (18%)
• Similarity: 608/1946 - (31%)
• Gaps: 709/1946 - (36%)

  Fly    22 RPPKVALSALGN--TPPHINPSLKHA-DAEASPTAPEDQDSGQSECRRSSRKKIIKFDVRDLLNK 83
            :|||    .|.|  .||.|..::|.: |.:.|.|....:.:.:.| |..|:||::  ...|....
Mouse   108 KPPK----NLENYICPPEIKITIKQSGDQKVSRTGKNSKATKEDE-RNHSKKKLL--TAGDPTAS 165

  Fly    84 NRKAHKIQIEARIDSNPS----TGHSQSGTT--------AASTSMSTATASAASASSAATVSRLF 136
            :.||.:.|...|...:.:    .||||..|:        ..|:|.|....|:.|.|..||.:
Mouse   166 DLKAFQTQAYERPQKHSTLQYDPGHSQGFTSDTLKPKHQQKSSSQSHMEWSSNSDSGPATQN--- 227

  Fly   137 SMFEMSHQSLPPPPPPPTALEIFAKPRPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRG 201
                                 .|..|.      ..:.|:..|.|....||.:.|
Mouse   228 ---------------------CFISPE------AGRDTASTSKVPALEPVASFA----------- 254

  Fly   202 RPRKSQLADAAIIPTVIVPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLKLG 266
               |:|                 |...||....|.:||.|                   |.|.||
Mouse   255 ---KAQ-----------------SKKGSTGGAWSQLSSSS-------------------KDLLLG 280

  Fly   267 GRLESSDSGNSPSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETES 331
            ..:.|..|.|||::.|...|...||.                :.|.:..|..|.        .|.
Mouse   281 SVVPSPSSHNSPATPSSSAECNGLQP----------------LGDQDGGSTKDL--------PEP 321

  Fly   332 PKGEEEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEI-----MVEVLSGPPSLWSADDE 391
            |....:::..:      :|:|...:          |..|||.:     ..|...|....:|||..
Mouse   322 PTLSSKKKSSK------KDMISQTL----------PNSDLDWVKSAQKAFETTEGKREAYSADSA 370

  Fly   392 AE-------------EEEDATVQRATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFA 443
            .|             .|.|::..|.|.|.|.|:.|. |:..|:.|:|
Mouse   371 QEASPARQSISSVSNPENDSSHVRITIPIKTPSLDP-SNHKRKKRQS------------------ 416

  Fly   444 EIAAESSKQILEAEESQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEA 508
                      ::|              ::|..:.|..:.|.:|      :..|||   |:::..:
Mouse   417 ----------IKA--------------VVEKIVPEKALASGIS------MSSEVV---NRILSNS 448

  Fly   509 DEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAATL 573
            :   .||::..:.|:....:|...|:.       :||.....::||            .|.:...
Mouse   449 E---GSKKDPRVPKLGKMIENETPSVG-------LETGGNAEKIVP------------GGASKQR 491

  Fly   574 EKSAVVTKPT-TEMIAETKLSDEVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVET 637
            :...|:|.|| ||.....|||:   |:.| |..:..:.::.:.|.......:..:|:::   ||.
Mouse   492 KPPMVMTSPTRTEHAPSGKLSE---IQHP-KFAAKRRCSKAKPPAMLREAVLATAEKLM---VEP 549

  Fly   638 TSS-PLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPAAP----EEEAS 697
            .|: |:.|         |.|:...|...|        ..||:|.:..:....|...    .|..|
Mouse   550 PSAYPITP---------SSPLYTNTDSLT--------VITPVKKKRGRPKKQPLLTVETIHEGTS 597

  Fly   698 NSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPAR 762
            .|...|  :..::...:::.....:.|.......:..|:.|||
Mouse   598 TSPVSP--ISREFPGTKKRKRRRNLAKLAQLVPGEDKPMSEMK---------------------- 638

  Fly   763 SSPAIVDKKV-RAGEMEKKVVKSTKGTVPEKKMDSKK-------SCAAVTPAKQKESGKSAKEAI 819
                 ..||| :.|.::||.:|    |:.:.|...:|       ||::....|.|...:::..|
Mouse   639 -----FHKKVGKLGVLDKKTIK----TINKMKTLKRKNILNQILSCSSSVALKAKAPPETSPGA- 693

  Fly   820 LKKETEKEKSSAKLDSSSPNTL---DKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQ 881
               .:.:.|...:::.|...|:   .|:|:.           |::...||.|.     .||....
Mouse   694 ---ASIESKLGKQINVSKRGTIYIGKKRGRK-----------PRTELPPPSEE-----PKTAIKH 739

  Fly   882 PAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPT 946
            |.|...|            |.|                                      ..||:
Mouse   740 PRPVSSQ------------PDV--------------------------------------PAVPS 754

  Fly   947 KVEAP----PKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSS-PSSDSAQANTSAGK 1006
            ..::|    |....|.:..:.|...:||..::....:..:..|||:..|: |:......:....|
Mouse   755 SFQSPVASSPAAMHPLSTQLGGSNGNLSPASTETNFSELKTMPNLQPISALPTKTQKGIHGGTWK 819

  Fly  1007 LKPSKVKKKINPRRSTICE--AAKDLRSSSSSSTPTRE-VAASSPVSTSSDSSSKRNGSKRTTSD 1068
            |.|.::... :|  |.:||  :.|::..|..|.:.:.| :.:.|.:.|.::|          |||
Mouse   820 LSPPRLMAN-SP--SHLCEIGSLKEITLSPVSESHSEETIPSDSGIGTDNNS----------TSD 871

  Fly  1069 LDGGSKLDQRRYT--ICEDRQPETAIPVPL-TKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGK 1130
            ....|...:|||:  .|....|| |||... ||.|   |.....:.:.||.|           ..
Mouse   872 QAEKSSESRRRYSFDFCSLDNPE-AIPSDTSTKNR---HGHRQKHLIVDTFL-----------AH 921

  Fly  1131 ESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEA-- 1193
            |||.:              ||.|..:.                    |..:|.|:|...|||.
Mouse   922 ESLKK--------------PKHKRKRK--------------------SLQNRDDLQFLAELEELI 952

  Fly  1194 -----------------ANPFGDIAK----------FIE-DGVNLLKRDKVDEDQRKEGQDEVKR 1230
                             .||:..|.:          :|: |.:..|:|....:.::|.|: ..|.
Mouse   953 TKFQVFRISHRGYTFYHENPYPSIFRINFDQYYPVPYIQYDPLLYLRRTSDLKSKKKRGR-PAKT 1016

  Fly  1231 EADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPR 1295
            .....:..|.|..       :.|.||.:...|.....|:..:..|...|         |.|....
Mouse  1017 NDTMTKVPFLQGF-------SYPIPSGSYYAPYGMPYTSMPMMNLGYYG---------QYPAPLY 1065

  Fly  1296 ASQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQ 1360
            .|...|.||..:.|.....|....::::...                     ..:..::....:
Mouse  1066 LSHTLGAASPFMRPTVPPPQFHASSHVKISG---------------------ATKHKAKHGVHL- 1108

  Fly  1361 CDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEK----- 1420
                       ||.:..|.|.|...|    .|....||..::.|..:.:....|..:.::
Mouse  1109 -----------QGTVGMGLGDIQPSL----NPPKVGGATLSSSRLHKRKHKHKRKHKEDRILGTH 1158

  Fly  1421 ---------KGCGITAELLIPPGEFIMEYVGEVIDSEE------FERRQHLYSKDRNRHYYFMAL 1470
                     |..|.::.||           .|.:...:      .|:.:|   |:|.:|.:
Mouse  1159 DNLSGLFAGKATGFSSHLL-----------SERLSGSDKELPLVSEKSKH---KERQKHQH---- 1205

  Fly  1471 RGEA---------VIDATSKGNISRYINHSCDPNAETQKWTV---NGELRIGFFSVKPIQPGEEI 1523
             |||         .:|..|..::|           :.|.||.   .|:|     |.:|::...:
Mouse  1206 -GEASHKVSKNNFEVDTLSTLSLS-----------DAQHWTQAKDKGDL-----SSEPVESCAK- 1252

  Fly  1524 TFDYQYLRYGRDAQR-----CYCEAANCRGWIGGEPDSD--------------EGEQLDEESDSD 1569
                :|...|.|:.|     .:.|.         .|.||              ||.....|.|..
Mouse  1253 ----RYSGSGGDSTRSEGLDVFSEM---------NPSSDKWDSDMGGSKRRSFEGFGTYREKDIQ 1304

  Fly  1570 A-EMDEEE---LEAEPEEGQPR---KSAKAKAKSKLKAKLPLATGRKRKEQTKPKDREYKAGRWL 1627
            | :|:.:|   .|:....|.|.   |..:..|.||.:..:.....||
Mouse  1305 AFKMNRKERGSYESSMSPGMPSPHLKVDQTAAHSKSEGSISAMMARK------------------ 1351

  Fly  1628 KPSATGSSSSAEKPPKKPKVNKFQAMLEDPDVVEELSLLRRGGLKNQQDTLRFSRCLVR-----A 1687
            ||:|..|.:.    |..|.::...|.....|.... ||.:|  .|.::  :...:|.||     .
Mouse  1352 KPTAVDSVAI----PSAPVLSLLAASAATSDAASS-SLKKR--FKRRE--IEAIQCEVRKMCHYT 1407

  Fly  1688 KLLKTRLALLRVLTHGELPCRRLFLDYHGLRLLHAWISENGND-------------DQLREALLD 1739
            |||.|:..|..|  :..|..:||...           |:.||:             .|..|   |
Mouse  1408 KLLSTKKNLDHV--NKILKAKRLQRQ-----------SKTGNNFVKKRRGRPRKQPSQFDE---D 1456

  Fly  1740 TLESLPIPNRTMLSDSRVYQSVQLWSNSLEQQLAVVPQEKQAALHKRMVALLQKWQALPEI 1800
            :.:.:|:..:.:...|:..|...|      ..||:.|...|.|:...:.|::...:..|.:
Mouse  1457 SRDQMPVLEKCIDLPSKRGQKPSL------SPLALEPASGQDAVMATIEAVIHMAREAPPL 1511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	10/51 (20%)
		SET	1414..1533	CDD:214614	25/150 (17%)
		PostSET	1535..1551	CDD:214703	3/20 (15%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Setbp1	NP_444329.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..246		32/154 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	278..416		39/178 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..513		18/88 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	595..617		3/23 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	709..787		22/143 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..880		10/44 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1128..1155		4/26 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1182..1215		8/40 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1236..1265		8/38 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1429..1461		6/45 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1470..1489		6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1507..1582		1/5 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848408
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930