DRSC/TRiP Functional Genomics Resources

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Protein Alignment Set2 and Setbp1

DIOPT Version :10

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:NP_444329.2 Gene:Setbp1 / 240427 MGIID:1933199 Length:1582 Species:Mus musculus


Alignment Length:1946 Identity:366/1946 - (18%)
Similarity:608/1946 - (31%) Gaps:709/1946 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 RPPKVALSALGN--TPPHINPSLKHA-DAEASPTAPEDQDSGQSECRRSSRKKIIKFDVRDLLNK 83
            :|||    .|.|  .||.|..::|.: |.:.|.|....:.:.:.| |..|:||::  ...|....
Mouse   108 KPPK----NLENYICPPEIKITIKQSGDQKVSRTGKNSKATKEDE-RNHSKKKLL--TAGDPTAS 165

  Fly    84 NRKAHKIQIEARIDSNPS----TGHSQSGTT--------AASTSMSTATASAASASSAATVSRLF 136
            :.||.:.|...|...:.:    .||||..|:        ..|:|.|....|:.|.|..||.:   
Mouse   166 DLKAFQTQAYERPQKHSTLQYDPGHSQGFTSDTLKPKHQQKSSSQSHMEWSSNSDSGPATQN--- 227

  Fly   137 SMFEMSHQSLPPPPPPPTALEIFAKPRPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRG 201
                                 .|..|.      ..:.|:..|.|....||.:.|           
Mouse   228 ---------------------CFISPE------AGRDTASTSKVPALEPVASFA----------- 254

  Fly   202 RPRKSQLADAAIIPTVIVPSCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLKLG 266
               |:|                 |...||....|.:||.|                   |.|.||
Mouse   255 ---KAQ-----------------SKKGSTGGAWSQLSSSS-------------------KDLLLG 280

  Fly   267 GRLESSDSGNSPSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETES 331
            ..:.|..|.|||::.|...|...||.                :.|.:..|..|.        .|.
Mouse   281 SVVPSPSSHNSPATPSSSAECNGLQP----------------LGDQDGGSTKDL--------PEP 321

  Fly   332 PKGEEEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEI-----MVEVLSGPPSLWSADDE 391
            |....:::..:      :|:|...:          |..|||.:     ..|...|....:|||..
Mouse   322 PTLSSKKKSSK------KDMISQTL----------PNSDLDWVKSAQKAFETTEGKREAYSADSA 370

  Fly   392 AE-------------EEEDATVQRATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFA 443
            .|             .|.|::..|.|.|.|.|:.|. |:..|:.|:|                  
Mouse   371 QEASPARQSISSVSNPENDSSHVRITIPIKTPSLDP-SNHKRKKRQS------------------ 416

  Fly   444 EIAAESSKQILEAEESQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEA 508
                      ::|              ::|..:.|..:.|.:|      :..|||   |:::..:
Mouse   417 ----------IKA--------------VVEKIVPEKALASGIS------MSSEVV---NRILSNS 448

  Fly   509 DEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAATL 573
            :   .||::..:.|:....:|...|:.       :||.....::||            .|.:...
Mouse   449 E---GSKKDPRVPKLGKMIENETPSVG-------LETGGNAEKIVP------------GGASKQR 491

  Fly   574 EKSAVVTKPT-TEMIAETKLSDEVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVET 637
            :...|:|.|| ||.....|||:   |:.| |..:..:.::.:.|.......:..:|:::   ||.
Mouse   492 KPPMVMTSPTRTEHAPSGKLSE---IQHP-KFAAKRRCSKAKPPAMLREAVLATAEKLM---VEP 549

  Fly   638 TSS-PLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPAAP----EEEAS 697
            .|: |:.|         |.|:...|...|        ..||:|.:..:....|...    .|..|
Mouse   550 PSAYPITP---------SSPLYTNTDSLT--------VITPVKKKRGRPKKQPLLTVETIHEGTS 597

  Fly   698 NSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPAR 762
            .|...|  :..::...:::.....:.|.......:..|:.|||                      
Mouse   598 TSPVSP--ISREFPGTKKRKRRRNLAKLAQLVPGEDKPMSEMK---------------------- 638

  Fly   763 SSPAIVDKKV-RAGEMEKKVVKSTKGTVPEKKMDSKK-------SCAAVTPAKQKESGKSAKEAI 819
                 ..||| :.|.::||.:|    |:.:.|...:|       ||::....|.|...:::..| 
Mouse   639 -----FHKKVGKLGVLDKKTIK----TINKMKTLKRKNILNQILSCSSSVALKAKAPPETSPGA- 693

  Fly   820 LKKETEKEKSSAKLDSSSPNTL---DKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQ 881
               .:.:.|...:::.|...|:   .|:|:.           |::...||.|.     .||....
Mouse   694 ---ASIESKLGKQINVSKRGTIYIGKKRGRK-----------PRTELPPPSEE-----PKTAIKH 739

  Fly   882 PAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPT 946
            |.|...|            |.|                                      ..||:
Mouse   740 PRPVSSQ------------PDV--------------------------------------PAVPS 754

  Fly   947 KVEAP----PKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSS-PSSDSAQANTSAGK 1006
            ..::|    |....|.:..:.|...:||..::....:..:..|||:..|: |:......:....|
Mouse   755 SFQSPVASSPAAMHPLSTQLGGSNGNLSPASTETNFSELKTMPNLQPISALPTKTQKGIHGGTWK 819

  Fly  1007 LKPSKVKKKINPRRSTICE--AAKDLRSSSSSSTPTRE-VAASSPVSTSSDSSSKRNGSKRTTSD 1068
            |.|.::... :|  |.:||  :.|::..|..|.:.:.| :.:.|.:.|.::|          |||
Mouse   820 LSPPRLMAN-SP--SHLCEIGSLKEITLSPVSESHSEETIPSDSGIGTDNNS----------TSD 871

  Fly  1069 LDGGSKLDQRRYT--ICEDRQPETAIPVPL-TKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGK 1130
            ....|...:|||:  .|....|| |||... ||.|   |.....:.:.||.|           ..
Mouse   872 QAEKSSESRRRYSFDFCSLDNPE-AIPSDTSTKNR---HGHRQKHLIVDTFL-----------AH 921

  Fly  1131 ESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEA-- 1193
            |||.:              ||.|..:.                    |..:|.|:|...|||.  
Mouse   922 ESLKK--------------PKHKRKRK--------------------SLQNRDDLQFLAELEELI 952

  Fly  1194 -----------------ANPFGDIAK----------FIE-DGVNLLKRDKVDEDQRKEGQDEVKR 1230
                             .||:..|.:          :|: |.:..|:|....:.::|.|: ..|.
Mouse   953 TKFQVFRISHRGYTFYHENPYPSIFRINFDQYYPVPYIQYDPLLYLRRTSDLKSKKKRGR-PAKT 1016

  Fly  1231 EADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPR 1295
            .....:..|.|..       :.|.||.:...|.....|:..:..|...|         |.|....
Mouse  1017 NDTMTKVPFLQGF-------SYPIPSGSYYAPYGMPYTSMPMMNLGYYG---------QYPAPLY 1065

  Fly  1296 ASQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQ 1360
            .|...|.||..:.|.....|....::::...                     ..:..::....: 
Mouse  1066 LSHTLGAASPFMRPTVPPPQFHASSHVKISG---------------------ATKHKAKHGVHL- 1108

  Fly  1361 CDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEK----- 1420
                       ||.:..|.|.|...|    .|....||..::.|..:.:....|..:.::     
Mouse  1109 -----------QGTVGMGLGDIQPSL----NPPKVGGATLSSSRLHKRKHKHKRKHKEDRILGTH 1158

  Fly  1421 ---------KGCGITAELLIPPGEFIMEYVGEVIDSEE------FERRQHLYSKDRNRHYYFMAL 1470
                     |..|.::.||           .|.:...:      .|:.:|   |:|.:|.:    
Mouse  1159 DNLSGLFAGKATGFSSHLL-----------SERLSGSDKELPLVSEKSKH---KERQKHQH---- 1205

  Fly  1471 RGEA---------VIDATSKGNISRYINHSCDPNAETQKWTV---NGELRIGFFSVKPIQPGEEI 1523
             |||         .:|..|..::|           :.|.||.   .|:|     |.:|::...: 
Mouse  1206 -GEASHKVSKNNFEVDTLSTLSLS-----------DAQHWTQAKDKGDL-----SSEPVESCAK- 1252

  Fly  1524 TFDYQYLRYGRDAQR-----CYCEAANCRGWIGGEPDSD--------------EGEQLDEESDSD 1569
                :|...|.|:.|     .:.|.         .|.||              ||.....|.|..
Mouse  1253 ----RYSGSGGDSTRSEGLDVFSEM---------NPSSDKWDSDMGGSKRRSFEGFGTYREKDIQ 1304

  Fly  1570 A-EMDEEE---LEAEPEEGQPR---KSAKAKAKSKLKAKLPLATGRKRKEQTKPKDREYKAGRWL 1627
            | :|:.:|   .|:....|.|.   |..:..|.||.:..:.....||                  
Mouse  1305 AFKMNRKERGSYESSMSPGMPSPHLKVDQTAAHSKSEGSISAMMARK------------------ 1351

  Fly  1628 KPSATGSSSSAEKPPKKPKVNKFQAMLEDPDVVEELSLLRRGGLKNQQDTLRFSRCLVR-----A 1687
            ||:|..|.:.    |..|.::...|.....|.... ||.:|  .|.::  :...:|.||     .
Mouse  1352 KPTAVDSVAI----PSAPVLSLLAASAATSDAASS-SLKKR--FKRRE--IEAIQCEVRKMCHYT 1407

  Fly  1688 KLLKTRLALLRVLTHGELPCRRLFLDYHGLRLLHAWISENGND-------------DQLREALLD 1739
            |||.|:..|..|  :..|..:||...           |:.||:             .|..|   |
Mouse  1408 KLLSTKKNLDHV--NKILKAKRLQRQ-----------SKTGNNFVKKRRGRPRKQPSQFDE---D 1456

  Fly  1740 TLESLPIPNRTMLSDSRVYQSVQLWSNSLEQQLAVVPQEKQAALHKRMVALLQKWQALPEI 1800
            :.:.:|:..:.:...|:..|...|      ..||:.|...|.|:...:.|::...:..|.:
Mouse  1457 SRDQMPVLEKCIDLPSKRGQKPSL------SPLALEPASGQDAVMATIEAVIHMAREAPPL 1511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 valS <709..832 CDD:237855 21/130 (16%)
AWS 1358..1410 CDD:197795 10/51 (20%)
SET_SETD2 1410..1551 CDD:380949 29/177 (16%)
WW 2014..2043 CDD:459800
SRI 2266..2355 CDD:462404
Setbp1NP_444329.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..76
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 124..246 32/154 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 278..416 39/178 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..513 18/88 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 595..617 3/23 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..787 22/143 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 845..880 10/44 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1155 4/26 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1182..1215 8/40 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1236..1265 8/38 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1429..1461 6/45 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1470..1489 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1507..1582 1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

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