DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and Setdb2

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_001307649.1	Gene:	Setdb2 / 239122	MGIID:	2685139	Length:	697	Species:	Mus musculus

Alignment Length:	644	Identity:	136/644 - (21%)
Similarity:	221/644 - (34%)	Gaps:	155/644 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1128 EGKESL---SRQNSLDS------SSSASQG--APKKKALKSAEILSAALLETESSESTSSGSKMS 1181
            :||..|   ..||.|.|      ..||:.|  ......:..|.:.:...||.:.:..|.| .:.:
Mouse    18 DGKVDLMFEKTQNVLHSLKQKIKDGSATNGDYVQAMNLVNEATLSNTQTLEKDHTPVTQS-EQEN 81

  Fly  1182 RWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVAN- 1245
            :.....|...:.:.|.|.........|.|..::|.|        :.||:|| |....|.:.:.:
Mouse    82 KSSAVPSASCDNSCPKGCTIPSPGKKVFLPVKNKAD--------NLVKKEA-PLHISFHRHICSR 137

  Fly  1246 ---METPATTPTPSPTQ-------------SNPEDSASTTTV-------LKELE----------- 1276
               ||||.:....:|.|             :|...||.....       |:.:|
Mouse   138 TCLMETPLSLKGENPLQLPIRCHFQRRHAKTNSHSSALHVNYKTPCGRNLRNMEEVFHYLLETEC 202

  Fly  1277 -----------TGGGVRRSHRIKQKPQGPRASQGRGVASVALAPISMDEQLAELANIEAINEQFL 1330
                       |...:.|:|. ||...........||.||:: |...:...::|...:..|..:.
Mouse   203 NFLFTDNFSFNTYVQLTRNHP-KQNEVVSDVDISNGVESVSI-PFCNEIDNSKLPRFKYRNTVWP 265

  Fly  1331 RSEGLNTFQLLKE---------NFYRCA-RQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRM 1385
            |...||...:..:         :..:|| .|::.:||:.   |.|:.|.|..|:   ....:.|:
Mouse   266 RIYHLNFSNMFSDSCDCSEGCIDIKKCACLQLTAKNAKA---CPLSSDGECAGY---KYKRLQRL 324

  Fly  1386 L---MIECGPLCS-NGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVID 1446
            :   :.||..||. |...|.|:..|.......:||::||||.|:.....|..|.|:..|.|.::.
Mouse   325 IPTGIYECNLLCKCNKQMCQNRVIQHGVRVRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLR 389

  Fly  1447 ---------SEEFERRQHL----YSKDRNRHYYFM----------------ALRG---EAVIDAT 1479
                     .|....:||:    :||.|.......                .|.|   |..::..
Mouse   390 RATPEKTNIGENGREQQHIVKNSFSKKRKLEVVCSDCDAHCDSPKAEDCPPKLSGDLKEPAVEMN 454

  Fly  1480 SKGNISRYINHSCDPNAETQKWTV--NGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCE 1542
            .: ||||..:||.....:: |.||  ..|..:||.......|.::..|.........:|:|.:.:
Mouse   455 HR-NISRTQHHSVIRRTKS-KTTVFHYSEKNMGFVCSDSAAPEDKNGFKPAQEHVNSEARRAHED 517

  Fly  1543 -AANCRGWIGGEPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAK-AKAKSKLKAKLPLA 1605
             ::|..|              |.|.....|.|..::.|..|:..|....| |....:...|..|.
Mouse   518 LSSNPAG--------------DSEDTQLTESDVIDITASREDSAPAYRCKHATIVDRKDTKQVLE 568

  Fly  1606 TGRKRKEQTKPK---------DREYKAGRWLKPSATGSSSSAEK-----PPKKPKVNKF 1650
            ...|:.::.:|.         |.|..:.|...|||:....|.|.     ..|:..|.:|
Mouse   569 VPGKKSQEEEPAASQSQQALCDEELPSERTKIPSASLMQLSKESLFLLDASKEGNVGRF 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	14/55 (25%)
		SET	1414..1533	CDD:214614	35/152 (23%)
		PostSET	1535..1551	CDD:214703	4/16 (25%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Setdb2	NP_001307649.1	HMT_MBD	152..212	CDD:238689	7/59 (12%)
		Pre-SET	234..346	CDD:282838	27/118 (23%)
		SET	354..>395	CDD:214614	12/40 (30%)
		SET	<612..674	CDD:214614	3/16 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848367
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930