DRSC/TRiP Functional Genomics Resources

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Protein Alignment Set2 and Nsd3

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:NP_001074738.1 Gene:Nsd3 / 234135 MGIID:2142581 Length:1446 Species:Mus musculus


Alignment Length:1616 Identity:340/1616 - (21%)
Similarity:537/1616 - (33%) Gaps:559/1616 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   146 LPPPPPPPTALEIFAKPRPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLAD 210
            ||||||||        |.|            ||.      .||      |.|:|.|.|.    ..
Mouse   136 LPPPPPPP--------PPP------------PSV------PQT------VIPKKTGSPE----IK 164

  Fly   211 AAIIPTVIVPSCSDSDTNSTSTTTSNMSSD-SGELPGFPIQKPKSKLRVSLKRLKLGGRLESSDS 274
            ..|..|:         .|......|::..| ..|:..  .:..|||.....::.|...|.|||.|
Mouse   165 LKITKTI---------QNGRELFESSLCGDLLNEVQA--SEHTKSKHESRKEKRKKSNRHESSRS 218

  Fly   275 GNSPSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQE 339
            ....|...|::||   :.:|..:||                         ::...|.|:.|...:
Mouse   219 EERRSHKIPKLEP---EGQNRPNER-------------------------VDTAPEKPREEPVLK 255

  Fly   340 EGRPVEVEPQDLIDIDMELAKQEPTPDPEEDL-----DEIMVEVLSGP--PSLWSADDEAEEEED 397
            |..||:           .:....||.:....:     |.:..:|.:.|  |.:.|:|.:.|....
Mouse   256 EAIPVQ-----------PILSSVPTTETSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHSK 309

  Fly   398 ATVQRATPPGKEPAADSCSSAPRRS----RRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEE 458
            ...:.|    :|......|:.|.|:    :|.....|        .|.:.|:.||::||.....|
Mouse   310 INTRGA----REYHVQFFSNQPERAWVHEKRVREYKG--------HEQYEELLAEAAKQASNHSE 362

  Fly   459 SQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKV 523
            .|.                                                          |:| 
Mouse   363 KQK----------------------------------------------------------IRK- 368

  Fly   524 FSESDNIAASLNKDIFEPKVETKATCGEVVPRP--EMVTEDVYITEGIAATLEKSAVVTKPTTEM 586
                                          |||  |....|:    |||.. ||:..:|:     
Mouse   369 ------------------------------PRPQRERAQWDI----GIAHA-EKALKMTR----- 393

  Fly   587 IAETKLSDEVVIEPPLKDESDPKQTEVELPESKPAVNIPKSER-ILSAEVETTSSPLVPPECCTL 650
              |.::.....|....:.|....|.:..: .||..|..|:..| :|:::.|.|::..|.....:.
Mouse   394 --EERVEQYTFIYIDKQPEEASSQAKKNV-TSKTEVKKPRRPRSVLNSQPEQTNAGEVASSQSST 455

  Fly   651 ESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPN----------F 705
            :.........|||..||.....:   ..||.||::..|.:....:.|...::.|          |
Mouse   456 DLRRQSQRRHTSLEEEEPPPVKI---AWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVF 517

  Fly   706 LLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDK 770
            .|::...:.:.:  |:.:......|.| |.: .::..::.:   :|...:..|.||:|:.:....
Mouse   518 ALQNATGDGKFI--DQFVYSTKGIGNK-TEI-SVRGQDRLI---ISSPSQRSEKPAQSASSPEAT 575

  Fly   771 KVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAK--QKESGKSAKEAILKKETEKEKSSAKL 833
            ...||.:|||..:.:..|    :.:|:|| |.|.|.|  :||..::|.:|.||...:|..|... 
Mouse   576 SGSAGPVEKKQQRRSIRT----RSESEKS-AEVVPKKKIKKEQVETAPQASLKTGLQKGASEIS- 634

  Fly   834 DSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKP------------PQESAPSVISKTTSNQPAPKE 886
            ||..|  |.|:.:.:........|...:|...            .|..:||..:...::. |...
Mouse   635 DSCKP--LKKRSRASTDVETASCTYRDTSDSDSRGLSDGQVGFGKQVDSPSATADADASD-AQSV 696

  Fly   887 EQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDA------MFKAMDLANAQLRLDEKNKKKLKKVP 945
            :...:::|:..:...:|.:..|||....|.|:.      ..:.:.|                   
Mouse   697 DSSLSRRGVGTSKKDTVCQVCEKAGDCLVACEGECCRHFHVECLGL------------------- 742

  Fly   946 TKVEAPPKVEPPTAVP---------VPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQAN 1001
                        ||||         ..||....|.|.|                   ..|..:.:
Mouse   743 ------------TAVPEGHFTCEECETGQHPCFSCKVS-------------------GKDVKRCS 776

  Fly  1002 TS-AGKLKPSKVKKKIN-----------PRR-STICEAAKDLRSSSSS------STPTRE----- 1042
            .| .||.......:|..           |:. .:.|...||:..:|..      ..|...     
Mouse   777 VSVCGKFYHEACVRKFPTAIFESKGFRCPQHCCSSCSMEKDIHKASKGRMMRCLRCPVAYHVGDA 841

  Fly  1043 -VAASSPVSTSSDSSSKRNGSKRTT----------------------SDLDGGSKLDQRRYTICE 1084
             |||.| ||.||......|.|||::                      ||....|...:..|.:.|
Mouse   842 CVAAGS-VSVSSHILICSNHSKRSSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSE 905

  Fly  1085 DRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGA 1149
            ..:.|.        .:..|.|.:||:           |||..|.|:       .|...|..:...
Mouse   906 SNRAEL--------MKLPMIPSSSAS-----------KKRCEKGGR-------LLCCESCPASFH 944

  Fly  1150 PKKKALKSAEILSAALLE-TESSESTSSGSKMS------------RW---DVQTSPELEAAN--- 1195
            |        |.||..:.| ..:.....:|.|:.            ||   :: .||.....|   
Mouse   945 P--------ECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEI-CSPRSVPLNIQG 1000

  Fly  1196 ---PFGDIAKF---------IEDG--VNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANM 1246
               ..||...|         :..|  ...::.||    ...|||..:.:......:|.|:|...:
Mouse  1001 LKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK----HFAEGQTSINKTFKKALEEAAKRFQEL 1061

  Fly  1247 ETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKP---QGPRASQGRGVASVALA 1308
            :          .|...:::.       |:|         |..:||   :..:|::..|...|   
Mouse  1062 K----------AQRESKEAL-------EME---------RTSRKPPPYKHIKANKVIGKVQV--- 1097

  Fly  1309 PISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTGDEEAQG 1373
                  |:|:|:.|.                                    :|:| ..|||.   
Mouse  1098 ------QVADLSEIP------------------------------------RCNC-KPGDEN--- 1116

  Fly  1374 HLSCG--AGCINRMLMIECGP-LCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGE 1435
              .||  :.|:|||...||.| :|..|.||.|:.|.:.......|.:||::|.|:..:..|..||
Mouse  1117 --PCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGE 1179

  Fly  1436 FIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQK 1500
            |:.|||||:||.||...|.....::...::|.:.:..:.:|||..|||.||::||||:||.||||
Mouse  1180 FVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQK 1244

  Fly  1501 WTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEE 1565
            |||||::|:|.|::..|..|.|:||:|.....|.....|:|.|.||.|::|..|.|.....:||:
Mouse  1245 WTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTVCHCGADNCSGFLGVRPKSACTSAVDEK 1309

  Fly  1566 SDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKRKEQTKPKDREY 1621
            :                     |:||.|.:.|:||            :.||...:|
Mouse  1310 T---------------------KNAKLKKRRKVKA------------EAKPIHEDY 1332

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 20/54 (37%)
SET 1414..1533 CDD:214614 52/118 (44%)
PostSET 1535..1551 CDD:214703 6/15 (40%)
WW 2014..2043 CDD:278809
SRI 2270..2348 CDD:285448
Nsd3NP_001074738.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 191..257 19/95 (20%)
MSH6_like 277..393 CDD:99898 34/221 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..377 10/111 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 411..476 15/65 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..705 37/166 (22%)
PHD_SF 713..755 CDD:304600 11/72 (15%)
PHD2_NSD3 761..807 CDD:277122 9/64 (14%)
PHD_SF 808..860 CDD:304600 13/52 (25%)
PHD4_NSD3 927..962 CDD:277128 9/49 (18%)
WHSC1_related 968..1061 CDD:99899 17/97 (18%)
AWS 1104..1154 CDD:197795 21/91 (23%)
SET 1155..1278 CDD:214614 52/122 (43%)
PHD5_NSD3 1332..1374 CDD:277131 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848411
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.880

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