DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and Setd1a

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_821172.2	Gene:	Setd1a / 233904	MGIID:	2446244	Length:	1716	Species:	Mus musculus

Alignment Length:	1770	Identity:	343/1770 - (19%)
Similarity:	578/1770 - (32%)	Gaps:	517/1770 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GPPSNPSPVA---SRGRGRGRPPKVALSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSECRR 66
            |.|.|.:|.:   :....|...|    |:.|...|..:....:....::|.:   |||..|....
Mouse   235 GTPGNGTPCSQDTNFSSSRQDTP----SSFGQFTPQSSQGTPYTSRGSTPYS---QDSAYSSSTT 292

  Fly    67 SSRKKIIKFDVRDLLNKNRKAHKIQIEAR---IDSNPSTGHSQSGTTAASTSMSTATASAASASS 128
            |:     .|..|    ::..:::.....|   ..|.|:|..:.:..|||:|:.|::::|::|:||
Mouse   293 ST-----SFKPR----RSENSYQDSFSRRHFSTSSAPATTATATSATAAATAASSSSSSSSSSSS 348

  Fly   129 AATVSRLFSMFEMSHQSLPP--------------PP---------------------PPPTALEI 158
            :::.|...|.|..|..|.|.              ||                     ||.....:
Mouse   349 SSSSSSSASQFRGSDSSYPAYYESWNRYQRHTSYPPRRATREDPSGASFAENTAERFPPSYTSYL 413

  Fly   159 FAKP--------RPTQSLIVAQVTSEPSAVGGA----------------HPVQTMAGLP--PVTP 197
            ..:|        ||..|........||...||.                .|.:..|..|  |.:|
Mouse   414 APEPNRSTDQDYRPPASEAPPPEPPEPGGGGGGSGGGGGGGGGGGGGAPSPEREEARTPPRPASP 478

  Fly   198 RKRGRPRKSQLADAAIIPTVIVPSCSDSDTNS---------------TSTTTSNMSSDSGELPGF 247
            .:.|.|......::       ||....|..:|               .::.|.....:|...||
Mouse   479 ARSGSPAPETTNES-------VPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSAGPG- 535

  Fly   248 PIQKPKSKLRVSLKRLKLGGRLESSDSGNSPSSSSP------EVEPPALQDENAMDERPKQE-QN 305
                           .:..|....|.:|:.|.:..|      :|.|....:..|..|.||.. ||
Mouse   536 ---------------ARDAGAEVPSGAGHGPCTPPPAPANFEDVAPTGSGEPGAARESPKANGQN 585

  Fly   306 LSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEED 370
            .:....:.|:         :||..:...|...     |....||           |.|.|.|...
Mouse   586 QASPCSSGED---------MEISDDDRGGSPP-----PAPTPPQ-----------QPPPPPPPPP 625

  Fly   371 LDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEPAA-------------DSCSSAPRRS 422
            ...        ||.|.|........:.|.:....|.|..|..             |..:|.....
Mouse   626 PPP--------PPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPPHIYDFVNSLELMD 682

  Fly   423 RRSAPLSG----------------SSRQGKTLEETFA-----------------EIAAESSKQIL 454
            |..|...|                ..||||.|....|                 :.||......|
Mouse   683 RLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLTAASAGPPGGAFGEAFLPFPPPQEAAYGLPYAL 747

  Fly   455 -----EAEESQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEI--- 511
                 |...|..:|..|:.:.:..:.|..|.| |.....:.|.  ||..:.|::::..|..:
Mouse   748 YTQGQEGRGSYSREAYHLPLPMAAEPLPSSSV-SGEEARLPHR--EEAEIAESKVLPSAGTVGRV 809

  Fly   512 ---LDSKQEFVIKKVFSES--DNIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAA 571
               |..:.:.::::..:..  :|:|.......:|.| |.||
Mouse   810 LATLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESK-EEKA------------------------ 849

  Fly   572 TLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVE 636
                     || .:..|:.:..:|           |.::.:::.|.....|:..||..|...|..
Mouse   850 ---------KP-FQNAAKQQAKEE-----------DKEKMKLKEPGMLSLVDWAKSGGITGIEAF 893

  Fly   637 TTSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSP-PAAPEEEASNSS 700
            ...|.|           .|.:.| .|...:.|....:      :||::|..| |:.|.||..:..
Mouse   894 AFGSGL-----------RGALRL-PSFKVKRKEPSEI------SEASEEKRPRPSTPAEEDEDDP 940

  Fly   701 EEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSP 765
            |......|......:....||.......|.:|...|.  .|.|:...|:.|:|::..::.....
Mouse   941 EREKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFTLD--SEGEEASQESSSEKDEDDDDEDEED- 1002

  Fly   766 AIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSS 830
               :::..|.:..||..:::.|  .::..||...|:....: ..|:|.::       ::|...||
Mouse  1003 ---EEQEEAVDATKKEAEASDG--EDEDSDSSSQCSLYADS-DGENGSTS-------DSESGSSS 1054

  Fly   831 AKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQE-----SAPSVISKTTSNQPAP------ 884
            :...|||.::.....:.:::...|...:|.:|  ||:|     .||....:|.....:|
Mouse  1055 SSSSSSSSSSSSSSSESSSEEEEQSAVIPSAS--PPREVPEPLPAPDEKPETDGLVDSPVMPLSE 1117

  Fly   885 KEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEK----------NKK 939
            ||.......|.::..||||.:...:..:|            ..:|..||||:          .||
Mouse  1118 KETLPTQPAGPAEEPPPSVPQPPAEPPAG------------PPDAAPRLDERPSSPIPLLPPPKK 1170

  Fly   940 KLKKVP-TKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYE--------DSPNLERNSSPSS 995
            :.|.|. :..|..|..||.||.|:  |.|| ||..|.:...|.|        |..:|.::.....
Mouse  1171 RRKTVSFSAAEEAPVPEPSTAAPL--QAKS-SGPVSRKVPRVVERTIRNLPLDHASLVKSWPEEV 1232

  Fly   996 DSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRN 1060
            .....|.:.|:::.::.::..............||     :.||.|...|:.|....|:::...:
Mouse  1233 ARGGRNRAGGRVRSTEEEEATESGTEVDLAVLADL-----ALTPARRGLATLPTGDDSEATETSD 1292

  Fly  1061 GSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRG 1125
            .::|.:..|  ...|.:..|.:.....|.|..|.||
Mouse  1293 EAERPSPLL--SHILLEHNYALAIKPPPTTPAPRPL----------------------------- 1326

  Fly  1126 RKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPE 1190
              |...:|:   :|.||       |..:.|::.|::.|   |.|..:....         |..||
Mouse  1327 --EPAPALA---ALFSS-------PADEVLEAPEVVVA---EAEEPKQQLQ---------QQHPE 1367

  Fly  1191 LEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANMET-----PA 1250
            .|.                  :.::.||::..|..:.....:..||....:|.....|     |.
Mouse  1368 QEG------------------EEEEEDEEEESESSESSSSSSSDEEGAIRRRSLRSHTRRRRPPL 1414

  Fly  1251 TTPTPSPTQSNPEDSASTTTVLKEL----------------------ETGGG--VRRSHRI---- 1287
            ..|.|.|....|.......|:|.::                      :|.|.  :..:|.:
Mouse  1415 PPPPPPPPSFEPRSEFEQMTILYDIWNSGLDLEDMSYLRLTYERLLQQTSGADWLNDTHWVQHTI 1479

  Fly  1288 --------KQKPQ-GPRASQGRGVASVALAPISMDE--QLAELANIEAINEQFLRSEGLNTFQLL 1341
                    |::|| |||..|.....|....|||..|  :..::..:.|...:...::|.|
Mouse  1480 TNLSTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQLEGGDTQGTN----- 1539

  Fly  1342 KENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGP---LCSNGARCTNK 1403
                    |.:|:..:|                        .|.|:...|.   :.|:..:....
Mouse  1540 --------RVLSERRSE------------------------QRRLLSAIGTSAIMDSDLLKLNQL 1572

  Fly  1404 RFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFM 1468
            :|::.:   .|..|:.....|:.|...|...|.::||||:.|.....:.|:..|.::.....|..
Mouse  1573 KFRKKK---LRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLF 1634

  Fly  1469 ALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYG 1533
            .:..:.:||||..||::|:|||.|.||...:..|:..:.:|..:|.:||...||||:||::....
Mouse  1635 RVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFPLED 1699

  Fly  1534 RDAQRCYCEAANCRG 1548
            .... |.|...:|||
Mouse  1700 NKIP-CLCGTESCRG 1713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	6/54 (11%)
		SET	1414..1533	CDD:214614	38/118 (32%)
		PostSET	1535..1551	CDD:214703	5/14 (36%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Setd1a	NP_821172.2	RRM_Set1A	92..186	CDD:240992
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..367		35/147 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..499		21/125 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..670		36/202 (18%)
		Topoisomer_IB_N	<835..>883	CDD:322080	12/93 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	849..869		6/64 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1206		76/333 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1230..1259		2/28 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1275..1297		3/21 (14%)
		HCFC1-binding motif (HBM). /evidence=ECO:0000250\|UniProtKB:O15047	1307..1311		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1355..1427		16/98 (16%)
		Interaction with CFP1. /evidence=ECO:0000250\|UniProtKB:O15047	1424..1459		3/34 (9%)
		N-SET	1434..1571	CDD:314603	27/173 (16%)
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000250\|UniProtKB:O15047	1459..1546		20/99 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1480..1508		8/27 (30%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000250\|UniProtKB:O15047	1501..1506		0/4 (0%)
		SET	1577..1700	CDD:214614	38/125 (30%)
		PostSET	1700..1716	CDD:214703	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848414
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870