Protein Alignment Set2 and EZH1

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_001308008.1
• Gene: EZH1 / 2145
• HGNCID: 3526
• Length: 753
• Species: Homo sapiens
• Alignment Length: 924
• Identity: 185/924 - (20%)
• Similarity: 305/924 - (33%)
• Gaps: 288/924 - (31%)

  Fly   748 ETVSKKEKAMENPARSSPAIV--DKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKE 810
            |..||.|  :.||. :|..|.  .:||::..|..:.:|..:..:      ..|:......||.:|
Human     2 EDYSKME--IPNPP-TSKCITYWKRKVKSEYMRLRQLKRLQANM------GAKALYVANFAKVQE 57

  Fly   811 SGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVIS 875
                 |..||.:|.:|                            |:..|..|.||  .|....:.
Human    58 -----KTQILNEEWKK----------------------------LRVQPVQSMKP--VSGHPFLK 87

  Fly   876 KTTSNQPAPK-EEQHAAKKGLSDNSPPSVLKAKEKAVSGF-VECDAMFKAMDLANAQLRLDEKNK 938
            |.|.....|. ..||...:.|:..:...::.:.......| ||.:.:     |.|.....||
Human    88 KCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQNFMVEDETV-----LCNIPYMGDE--- 144

  Fly   939 KKLKKVPTKVEAPPKVEPPTAV---------PVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPS 994
                         .|.|..|.:         .|.|:::.:.|.. |..:.|:.:..:.....|..
Human   145 -------------VKEEDETFIEELINNYDGKVHGEEEMIPGSV-LISDAVFLELVDALNQYSDE 195

  Fly   995 SDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKR 1059
            .:....:||.||...||                :||                 ||:
Human   196 EEEGHNDTSDGKQDDSK----------------EDL-----------------PVT--------- 218

  Fly  1060 NGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKR 1124
              .||....::|..|..::::       |...|...:.    ||.|:   |.:.|.:     |:|
Human   219 --RKRKRHAIEGNKKSSKKQF-------PNDMIFSAIA----SMFPE---NGVPDDM-----KER 262

  Fly  1125 GRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLET-------------ESSESTSS 1176
            .|:  ...:|..|:|....:.:...|..|:::..:.|.:  ..|             ....:|.:
Human   263 YRE--LTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHS--FHTLFCRRCFKYDCFLHPFHATPN 323

  Fly  1177 GSKMSRWDVQTSPELEAANPFGDIAKFIEDGVN---LLKRDKVDEDQRKEGQDEV---------- 1228
            ..|....:::..||     |.|.....:.:|..   :|...:.....|:..:..:
Human   324 VYKRKNKEIKIEPE-----PCGTDCFLLLEGAKEYAMLHNPRSKCSGRRRRRHHIVSASCSNASA 383

  Fly  1229 -----KREADPEED---EFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSH 1285
                 .:|.|.:.|   ::|...:...:...|||.......|..........:.:|..|......
Human   384 SAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLF 448

  Fly  1286 RIKQKPQGPRASQGRGVASVA-LAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENF---- 1345
            |:.      ..:......|:| |......:|:.:.|..|::..:....|.:|..|..|...
Human   449 RVF------HGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILKLPTDELMNPSQKKKRKHRLWA 507

  Fly  1346 YRCAR-QVSQENAEMQ-----------------CDCFLTGDEEAQGHLSCGAGCINRMLMIECGP 1392
            ..|.: |:.::|:..|                 |.|.:|.:       .|...|       :|.|
Human   508 AHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQN-------FCEKFC-------QCNP 558

  Fly  1393 LCSN---GARC-TNKRFQQHQC--------------------WPCRVFRTEKKGC----GITAEL 1429
            .|.|   |.|| |....:|..|                    |.|:|  ...|.|    |:...|
Human   559 DCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKV--VSCKNCSIQRGLKKHL 621

  Fly  1430 LIPP----------------GEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDA 1478
            |:.|                .|||.||.||:|..:|.:||..:|  |:....:...|..:.|:||
Human   622 LLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVY--DKYMSSFLFNLNNDFVVDA 684

  Fly  1479 TSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEA 1543
            |.|||..|:.|||.:||...:...|||:.|||.|:.:.||.|||:.|||:|            ..
Human   685 TRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRY------------SQ 737

  Fly  1544 ANCRGWIGGEPDSD 1557
            |:...::|.|.::|
Human   738 ADALKYVGIERETD 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	21/85 (25%)
		AWS	1358..1410	CDD:197795	15/72 (21%)
		SET_SETD2	1410..1551	CDD:380949	54/180 (30%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
EZH1	NP_001308008.1	EZH2_WD-Binding	45..74	CDD:463308	10/61 (16%)
		PRC2_HTH_1	165..268	CDD:436286	29/168 (17%)
		SANT	439..480	CDD:238096	8/46 (17%)
		preSET_CXC	566..597	CDD:408079	6/30 (20%)
		SET_EZH1	614..749	CDD:380994	50/148 (34%)