DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Set2 and EZH1

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:NP_001308008.1 Gene:EZH1 / 2145 HGNCID:3526 Length:753 Species:Homo sapiens


Alignment Length:924 Identity:185/924 - (20%)
Similarity:305/924 - (33%) Gaps:288/924 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   748 ETVSKKEKAMENPARSSPAIV--DKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKE 810
            |..||.|  :.||. :|..|.  .:||::..|..:.:|..:..:      ..|:......||.:|
Human     2 EDYSKME--IPNPP-TSKCITYWKRKVKSEYMRLRQLKRLQANM------GAKALYVANFAKVQE 57

  Fly   811 SGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVIS 875
                 |..||.:|.:|                            |:..|..|.||  .|....:.
Human    58 -----KTQILNEEWKK----------------------------LRVQPVQSMKP--VSGHPFLK 87

  Fly   876 KTTSNQPAPK-EEQHAAKKGLSDNSPPSVLKAKEKAVSGF-VECDAMFKAMDLANAQLRLDEKNK 938
            |.|.....|. ..||...:.|:..:...::.:.......| ||.:.:     |.|.....||   
Human    88 KCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQNFMVEDETV-----LCNIPYMGDE--- 144

  Fly   939 KKLKKVPTKVEAPPKVEPPTAV---------PVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPS 994
                         .|.|..|.:         .|.|:::.:.|.. |..:.|:.:..:.....|..
Human   145 -------------VKEEDETFIEELINNYDGKVHGEEEMIPGSV-LISDAVFLELVDALNQYSDE 195

  Fly   995 SDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKR 1059
            .:....:||.||...||                :||                 ||:         
Human   196 EEEGHNDTSDGKQDDSK----------------EDL-----------------PVT--------- 218

  Fly  1060 NGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKR 1124
              .||....::|..|..::::       |...|...:.    ||.|:   |.:.|.:     |:|
Human   219 --RKRKRHAIEGNKKSSKKQF-------PNDMIFSAIA----SMFPE---NGVPDDM-----KER 262

  Fly  1125 GRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLET-------------ESSESTSS 1176
            .|:  ...:|..|:|....:.:...|..|:::..:.|.:  ..|             ....:|.:
Human   263 YRE--LTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHS--FHTLFCRRCFKYDCFLHPFHATPN 323

  Fly  1177 GSKMSRWDVQTSPELEAANPFGDIAKFIEDGVN---LLKRDKVDEDQRKEGQDEV---------- 1228
            ..|....:::..||     |.|.....:.:|..   :|...:.....|:..:..:          
Human   324 VYKRKNKEIKIEPE-----PCGTDCFLLLEGAKEYAMLHNPRSKCSGRRRRRHHIVSASCSNASA 383

  Fly  1229 -----KREADPEED---EFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSH 1285
                 .:|.|.:.|   ::|...:...:...|||.......|..........:.:|..|......
Human   384 SAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLF 448

  Fly  1286 RIKQKPQGPRASQGRGVASVA-LAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENF---- 1345
            |:.      ..:......|:| |......:|:.:.|..|::..:....|.:|..|..|...    
Human   449 RVF------HGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILKLPTDELMNPSQKKKRKHRLWA 507

  Fly  1346 YRCAR-QVSQENAEMQ-----------------CDCFLTGDEEAQGHLSCGAGCINRMLMIECGP 1392
            ..|.: |:.::|:..|                 |.|.:|.:       .|...|       :|.|
Human   508 AHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQN-------FCEKFC-------QCNP 558

  Fly  1393 LCSN---GARC-TNKRFQQHQC--------------------WPCRVFRTEKKGC----GITAEL 1429
            .|.|   |.|| |....:|..|                    |.|:|  ...|.|    |:...|
Human   559 DCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKV--VSCKNCSIQRGLKKHL 621

  Fly  1430 LIPP----------------GEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDA 1478
            |:.|                .|||.||.||:|..:|.:||..:|  |:....:...|..:.|:||
Human   622 LLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVY--DKYMSSFLFNLNNDFVVDA 684

  Fly  1479 TSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEA 1543
            |.|||..|:.|||.:||...:...|||:.|||.|:.:.||.|||:.|||:|            ..
Human   685 TRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRY------------SQ 737

  Fly  1544 ANCRGWIGGEPDSD 1557
            |:...::|.|.::|
Human   738 ADALKYVGIERETD 751

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 15/72 (21%)
SET 1414..1533 CDD:214614 50/138 (36%)
PostSET 1535..1551 CDD:214703 1/15 (7%)
WW 2014..2043 CDD:278809
SRI 2270..2348 CDD:285448
EZH1NP_001308008.1 EZH2_WD-Binding 45..73 CDD:288468 10/60 (17%)
SANT 439..480 CDD:238096 8/46 (17%)
SANT 439..480 CDD:197842 8/46 (17%)
SET <469..733 CDD:225491 75/281 (27%)
SET 619..740 CDD:214614 47/134 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158032
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.