DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and Ash1l

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_619620.3	Gene:	Ash1l / 192195	MGIID:	2183158	Length:	2958	Species:	Mus musculus

Alignment Length:	2689	Identity:	536/2689 - (19%)
Similarity:	899/2689 - (33%)	Gaps:	873/2689 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PKVALSALGNTPPHINPSLKHADAEA-----------------SPTAPEDQDSGQSECRRSSRKK 71
            |::: |:||..|...:.|..||...:                 :.|||:...........|.:.|
Mouse   643 PRIS-SSLGKKPSLTSDSGIHAITPSVVNFTSLFSNKPFLKLGAVTAPDKHCQVAESLSSSFQSK 706

  Fly    72 IIKFDVRDLLNKNRKAHKIQIEARIDSNPSTG--------------HSQSGTTAASTSMSTATAS 122
            .:|      ..|.||....::.||.......|              .|.|.::..:..|.|..||
Mouse   707 PLK------KRKGRKPRWTKVVARSTCRSPKGLDLERSELFKNVSCSSLSNSSEPAKFMKTIGAS 765

  Fly   123 A-------------ASASSAATVSRLFSMFEMSHQSLPPPPPPPTALEIFAKPRPTQSLIVAQVT 174
            :             .|.|||.:::.|....:.||:|             |...:.:.|:.   ||
Mouse   766 SFVDHDFLKRRLPKLSKSSAPSLALLTDSEKPSHKS-------------FITHKLSSSMC---VT 814

  Fly   175 SEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAAIIP--TVIVPSCSDSDTNSTSTTTSNM 237
            |:.              |..:...|||||:..::......|  |:.:|:.......|.......:
Mouse   815 SDL--------------LSDIYKPKRGRPKSKEMPQLEGPPKRTLKIPASKVFSLQSKEEQEPPI 865

  Fly   238 SSDSGELPGF-------PIQK----PKSKLR--VSLKRLKLG----------GRLESSDSGNSPS 279
            .....|:|.|       |..|    ||.::|  |.:|...|.          .:|| |:|.|..|
Mouse   866 LQPEIEIPSFKQSLSVSPFPKKRGRPKRQMRSPVKMKPPVLSVAPFVATESPSKLE-SESENHRS 929

  Fly   280 SSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSD------------------------- 319
            ||........|||.:.:|:  ...|::..|.|.|...|..
Mouse   930 SSDFFESEDQLQDTDDLDD--SHRQSVCSMSDLEMEPDKKISKRNNGQLMKTIIRKINKMKTLKR 992

  Fly   320 ----SQIIFIEIETESPKGEEE---------------QEEGRPVEVEPQDLIDIDMELAKQEPTP 365
                :||:...:|: |.||:.:               .:.|:.:.|..:..|.|.....::..|
Mouse   993 KKLLNQILSSSVES-SNKGKVQSKLHNTVSSLAATFGSKLGQQINVSKKGTIYIGKRRGRKPKT- 1055

  Fly   366 DPEEDLDEIMVEVLSG-PPSLWSADDEAEEEEDATVQRATPP-GKEPAADS-------CSSAPRR 421
                    ::..:||| |.||...:..|::...:.:.:..|| ...||:.|       ||.:...
Mouse  1056 --------VLNGLLSGSPASLAVLEQTAQQAAGSALGQILPPLLPSPASSSEILPSPICSQSSGT 1112

  Fly   422 SRRSAPLSGS---------------SRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDL 471
            |...:|:|..               ||||..: :|.|...|...::.|...........|:
Mouse  1113 SGGQSPVSSDAGFVEPSSVPYLHVHSRQGSMI-QTLAMKKASKGRRRLSPPTLLPNSPSHL---- 1172

  Fly   472 IEDTLSESEVTS----SVSPTIEHMVVEEVV------VEENQLVDEADEILDSKQ---EFV-IKK 522
                   ||:||    :.||..|....|.:.      .:.|...|.|::....|:   .|. |..
Mouse  1173 -------SELTSLKEATPSPVSESHSDETIPSDSGIGTDNNSTSDRAEKFCGQKKRRHSFEHISL 1230

  Fly   523 VFSESDNIAASLNKD-------------IFEPKVETKATCGEVVPR------PEMVTE------- 561
            :..|:..:..||.:.             .::.....|....:..|:      |:.:.|
Mouse  1231 IPPETSTVLNSLKEKHKHKCKRRSHDYLSYDKMKRQKRKRKKKYPQLRNRQDPDFIAELEELISR 1295

  Fly   562 --DVYIT--------EGIAATLEK---SAVVTKPTTEMIAETKLSDEV--VIEPPLKDE--SDPK 609
              ::.||        ..:..|:.:   ::..|.|:..:       |.:  :.:|.||.:  ..||
Mouse  1296 LSEIRITHRSHHFIPRDLLPTIFRINFNSFYTHPSFPL-------DPLHYIRKPDLKKKRGRPPK 1353

  Fly   610 QTE----------VELPESK----PAVNIPKSERILSA-------------------EVETTSSP 641
            ..|          :..|.|.    |:..:|.|...|:|                   ...:.::|
Mouse  1354 MREAMAEMPFMHSLSFPLSSTGFYPSYGMPYSPSPLTAAPIGLGYYGRYPPTLYPPPPSPSFTTP 1418

  Fly   642 LVPPECCTLESVSGPVLLETSLSTEEKS---NENVETTPLKTEAAKEDSPPAAPEEEASNSSEEP 703
            |.||....    :|.:||..:...::|.   .:....|..:|......:.|:.|.|.|.
Mouse  1419 LPPPSYMH----AGHLLLNPTKYHKKKHKLLRQEAFLTTSRTPLLSMSTYPSVPPEMAY------ 1473

  Fly   704 NFLLE----------DYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAME 758
            .:::|          ::.|.|.||:.|        .|..::.|..:
Mouse  1474 GWMVEHKHRHRHKHREHRSEQPQVSMD--------SGSSRSVLESL------------------- 1511

  Fly   759 NPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKK-----SCAAVTPAKQKESGKSAKEA 818
                       |:.|.|          |.||.::....:|     ||..::|:|.
Mouse  1512 -----------KRYRFG----------KDTVGDRYKHKEKHRCHMSCPHLSPSKN---------- 1545

  Fly   819 ILKKETE------KEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKT 877
            ::.:|.:      .|.||..|...:|..:|                       ..||:||:
Mouse  1546 LINREEQWVSREPSESSSLALGLQTPLQID-----------------------CSESSPSL---- 1583

  Fly   878 TSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLK 942
                         :..|.:.||.|:             ..|........|....|:...|....|
Mouse  1584 -------------SLGGFTPNSEPA-------------SSDEHMNLFTSAIGSCRVSNPNSSCRK 1622

  Fly   943 KVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKL 1007
            |:         .:.|...||.        .|:|.|....|..|:.||.....:.|..|:.
Mouse  1623 KL---------TDSPGLFPVQ--------DTALNRPHRKEPLPSSERAIQSLAGSQSASD----- 1665

  Fly  1008 KPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSP--VSTSSDS--------------- 1055
            |||:     ....||.|...:...||.|:|:....|.:.||  |::..||
Mouse  1666 KPSQ-----RSSESTNCSPTRKRSSSESTSSTVNGVPSRSPRLVASMDDSVDSLLQRIVHHDEQE 1725

  Fly  1056 SSKRNGSKRTTS-----DLDGGSKLDQRRYTICEDRQPETAIP------VPLTKRRFSMHPKASA 1109
            |.::||....|:     ....|....:.|.....|.....|:|      :||...:.:  .:.|.
Mouse  1726 SMEKNGDASITTVSAPPSSSPGHSYSKERALGKSDSLLVPAVPNDSCSNIPLLSEKSA--SRCSP 1788

  Fly  1110 NPLHDTLLQTAGKKRGRK--------EGKESLSRQNSLDSSSSASQ-------------GAPKKK 1153
            :.:..:::: |.:::.||        ..|::|...|.:..:....:             |.|:|.
Mouse  1789 HHIKRSVVE-AMQRQARKMCNYDKILATKKNLDHVNKILKAKKLQRQARTGNNFVKRRPGRPRKC 1852

  Fly  1154 ALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDE 1218
            .|::...:.|.......|...:.|..||   :..||:...     |:.:.:...|||....|...
Mouse  1853 PLQAVVSMQAFQAAQFVSPELNEGEDMS---LHLSPDTVT-----DVIEAVVQSVNLTSEHKKGV 1909

  Fly  1219 DQRK---EGQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGG 1280
            .::.   |.|...|::..|||:|.....:.:|||...|:|..|.:.|.:..:|...:..|
Mouse  1910 KRKNWLLEEQTRKKQKTVPEEEEQENNKSFIETPVEIPSPLETPAEPSEPENTLQPVLAL----- 1969

  Fly  1281 VRRSHRIKQKPQGPRAS-QGRGVASVALAPISMDEQLAEL------------------ANIEAIN 1326
               ..|.|:.|:.|:.. |..|:.|.....|....:|.:|                  |.|..
Mouse  1970 ---IPREKKAPRPPKKKYQRAGLYSDVYKTIDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHV-- 2029

  Fly  1327 EQFLRSEGLNTFQL------------------------LKENFYRCARQVSQENAEMQCDCFLTG 1367
            .::||.:.:: |||                        ::.|.|...:.:|...| ..|:|....
Mouse  2030 GKYLRQKRID-FQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEA-TTCNCKKPD 2092

  Fly  1368 DEEAQGHLSCGAGCINRMLMIECGP-LCSNGARCTNKRFQQHQCWPC-RVFRTEKKGCGITAELL 1430
            |:..:|   ||..|:|||:..||.| .|..|.:|.|:|.|:|:...| ..||.|:||.||..:..
Mouse  2093 DDTRKG---CGDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEP 2154

  Fly  1431 IPPGEFIMEYVGEVIDSEEFERRQ----HLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHS 1491
            :..|:||:||:|||:..:||..|.    |.:|     .:|.:.|....|||:...||.:|:||||
Mouse  2155 LKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHS-----DHYCLNLDSGMVIDSYRMGNEARFINHS 2214

  Fly  1492 CDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQR-CYCEAANCRGWIGGEPD 1555
            ||||.|.|||:|||..|||.:::|.:..|.|:|:||.:..:..:.|: |.|....|||.|||:..
Mouse  2215 CDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQ 2279

  Fly  1556 SDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKRKE-------- 1612
            ...|....:.|.|.:              ..||||:||.|.|.|.||....|...:|
Mouse  2280 RMNGLPSHKGSQSSS--------------THRKSARAKEKRKSKHKLKKRKGHPSEEPSENINTP 2330

  Fly  1613 -------QTKP----------KDREYKAGRWLKPSATGSSSSAEKPPKKPKVNKFQAMLEDPDVV 1660
                   |.||          |...:....|                  .|:::.|..::....:
Mouse  2331 TRLTPQLQMKPMSNRERNFVLKHHVFLVRNW------------------EKIHQKQEEVKHTRDI 2377

  Fly  1661 EELSLLRR--------GGLKNQQDTLRFSRCLVRAKLLKTRLALLRVLTHGELPCRRLFLDYHGL 1717
            ...||..|        |.:|:.....:|| .|..|:.::||
Mouse  2378 HSASLYTRWNGLCRDDGNIKSDVFMTQFS-ALQTARSVRTR------------------------ 2417

  Fly  1718 RLLHAWISENGNDDQLREALLDTLESLPIPNRTMLSD--SRVYQSVQLWSNSLEQQLA-----VV 1775
            ||..|                  .|:|.:.....|:.  ..:...:..:.:|.:|.||     :.
Mouse  2418 RLAAA------------------EENLEVARAARLAQIFKEICDGIISYRDSSQQTLAAPLLNLP 2464

  Fly  1776 PQEKQAALHKRMVALLQKWQALPEIFRIPKRERIEQMKEHER-EADRQQKHVHASTALEDQRERE 1839
            |::|.|..::::...|       ::..|.|:..|...|..|. :||..:...:|    |....|:
Mouse  2465 PKKKNADYYEKISDPL-------DLSTIEKQILIGYYKTVEAFDADMLKVFRNA----EKYYGRK 2518

  Fly  1840 S--SND--RFRQDRF-RRDTTSSRIGKPIRMSGNNTICTITTQQKGSNGAPDGMTRNDNRRRSDI 1899
            |  ..|  |.|:..: .|...|::|.:.:    ..|.....:.:...:....|..::|:..|...
Mouse  2519 SPIGRDVCRLRKAYYSARHEASAQIDEIV----GETASEADSSETSVSEKESGHEKDDDVIRCIC 2579

  Fly  1900 GPPSEQRRTLSKELRRSLFERKVALDEAERRVCTEDRLEHELRCEFFGADINTDPKQLPFYQKTD 1964
            |                |::     ||.....|  |:......|:..|  :|||.:.. ..::.|
Mouse  2580 G----------------LYK-----DEGLMIQC--DKCMVWQHCDCMG--VNTDVEHY-LCEQCD 2618

  Fly  1965 TNEWFNSDDVPVPAPPRTELLTK------ALLSPDIDVGQGATDVEY------KLPPGVDPLPPA 2017
            .    ...|..||..||......      .||..|:.:.||  |..|      :.|.|   .|..
Mouse  2619 P----RPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQG--DCVYLMRDSRRTPDG---HPVR 2674

  Fly  2018 WNWQVTSDGDIYYYNLRERISQWEPPSPEQRLQTLLEENTTQ---------QPLHELQIDPA--V 2071
            .::::.|     :.| |:::..:       |::.|.:....:         :| ||....|:  .
Mouse  2675 QSYRLLS-----HIN-RDKLDIF-------RIEKLWKNEKEERFAFGHHYFRP-HETHHSPSRRF 2725

  Fly  2072 LENELIQVD-------TDYVGSLSAKSLAQYIEAK---VRERR----DLRRSKLVSI-------- 2114
            ..|||.:|.       ...||:.....|..|.:.:   ::|:.    |.|..|...:
Mouse  2726 YHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGIKEQDVYICDYRLDKSAHLFYKIHRNR 2790

  Fly  2115 --------------RLISPRRDEDRLYNQLESRKYKENKEKIRRRKELYRRRKIEVLPDAVDEIP 2165
                          :.::|:||....|   ....||.|..:...:.|    |....|.|...|
Mouse  2791 YPVCTKPYAFDHFPKKLTPKRDFSPHY---VPDNYKRNGGRSSWKSE----RSKPPLKDLGQE-- 2846

  Fly  2166 VPGKALPIQPYLFSSDEEETKVAAIEQPAAEEEQDSLNMAPSTSHAAMAALGKAVAQPTGLGTVG 2230
              ..|||:...:.:|.|:    ||.|.|:.||..         ...|...:|.|..:|    ...
Mouse  2847 --DDALPLIEEVLASQEQ----AAREVPSPEEPD---------QERATGDIGDAEKKP----EES 2892

  Fly  2231 KRKLPMPPSVTVKKHRQEQRSKKV 2254
            .::..:..:...::|.|.:|..::
Mouse  2893 SQEAQLASTPEERRHSQRERLNQI 2916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	20/52 (38%)
		SET	1414..1533	CDD:214614	52/122 (43%)
		PostSET	1535..1551	CDD:214703	6/16 (38%)
		WW	2014..2043	CDD:278809	4/28 (14%)
		SRI	2270..2348	CDD:285448
Ash1l	NP_619620.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..137
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..580
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	823..843		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..963		24/88 (27%)
		motB	<1061..1187	CDD:183756	32/137 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1094..1126		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1149..1219		14/80 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1243..1279		2/35 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1599		7/49 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1613..1704		28/117 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1722..1754		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1921..1941		5/19 (26%)
		Catalytic domain. /evidence=ECO:0000250	2059..2278		86/227 (38%)
		AWS	2082..2133	CDD:197795	21/54 (39%)
		SET_ASH1L	2136..2276	CDD:380951	60/144 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2278..2334		16/69 (23%)
		Bromo_ASH1	2432..2537	CDD:99955	23/115 (20%)
		PHD_ASH1L	2575..2617	CDD:277023	12/67 (18%)
		BAH_polybromo	2654..2788	CDD:240068	28/152 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2814..2846		8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2861..2909		12/64 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848371
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.870