DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Set2 and set-12

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_509306.2	Gene:	set-12 / 187229	WormBaseID:	WBGene00019584	Length:	389	Species:	Caenorhabditis elegans

Alignment Length:	403	Identity:	119/403 - (29%)
Similarity:	164/403 - (40%)	Gaps:	83/403 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1339 QLLKEN-----------FYRCARQVSQENAEMQCDCFLTGDEEAQGHL---SCGAG-------CI 1382
            ||.|:|           |:...|::...        |:...:...|.|   ||..|       |.
Worm    13 QLTKKNNSVFVYNTDPKFFPNTRRMDYS--------FICSPKRKTGLLTVTSCKCGTDCTTEECS 69

  Fly  1383 NRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKK-GCGITAELLIPPGEFIMEYVGEVID 1446
            |.....||...|||   |.|:||::.|......|.|:.. |.|:.|...|..|:.|:||.||.|.
Worm    70 NFANHRECPRGCSN---CENQRFRKRQFCGVETFLTDNGIGHGLRATEEIATGKLILEYRGEAIT 131

  Fly  1447 SEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGE--LRI 1509
            ..|..:|...|.||..:|.|...:.....:|.|.|||.:|:|||||:|||..:.|||...  ..:
Worm   132 KAEHNKRVKRYKKDGIKHSYSFEVGRNYYVDPTRKGNSARFINHSCNPNALVKVWTVPDRPMKSL 196

  Fly  1510 GFFSVKPIQPGEEITFDYQYLRYG---RDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDSDAE 1571
            |.|:.|.|:||||||||     ||   |:.|.|.|..|.||||| |:|.:.|   :.::...:.:
Worm   197 GIFASKVIKPGEEITFD-----YGTSFRNDQPCQCGEAACRGWI-GKPSTSE---VPKDVSKELK 252

  Fly  1572 MDEEELEAEPEEGQPRKSAKAKAKSKLKAKLPL---ATGRKRK-EQTKPKDREYKAGRWLKPSAT 1632
            ....:.:.:|.......|.....|.||...:|:   ..||||| :.|.|.....|..|. .|.|.
Worm   253 KRGRKPKMDPTAPISTTSTGGGDKGKLSGTIPVPKSRRGRKRKTDVTAPVPLATKTKRH-SPPAE 316

  Fly  1633 GSSSSAE--KPPKKPKVNKFQAMLEDPDVVEELSLLRRGGLKNQQDTLRFSRCLVRAKLLKTRLA 1695
            ..|...|  |||            .:.|:...::.|......||...|...|.::
Worm   317 NESEDKENVKPP------------SEEDITNAMNNLLNKTYDNQNGVLDECRSIM---------- 359

  Fly  1696 LLRVLTHGELPCR 1708
                   |.|.|:
Worm   360 -------GNLECK 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	17/61 (28%)
		SET	1414..1533	CDD:214614	49/121 (40%)
		PostSET	1535..1551	CDD:214703	8/15 (53%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
set-12	NP_509306.2	AWS	53..94	CDD:197795	14/43 (33%)
set-12	NP_509306.2	SET	97..221	CDD:214614	52/128 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156269
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4442
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002762
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102278
Panther	1	1.100	-	-	O	PTHR22884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.770