Protein Alignment Set2 and set-19

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_001379854.1
• Gene: set-19 / 180834
• WormBaseID: WBGene00020919
• Length: 953
• Species: Caenorhabditis elegans
• Alignment Length: 1071
• Identity: 205/1071 - (19%)
• Similarity: 350/1071 - (32%)
• Gaps: 359/1071 - (33%)

  Fly  1280 GVRRSHRI-------KQKPQGPRAS----QGRGVASVALAPISMDEQLAELANIEAINEQFLRSE 1333
            |:.|:.|:       |:|.|.|...    :|:.|..::..|   ||            ||..||:
 Worm     8 GMMRTVRMNAIRPSSKEKEQRPTPKLPLIKGKSVPMISELP---DE------------EQNHRSK 57

  Fly  1334 --GLNTFQLLKENFY-RCARQVSQENAEMQ--------CDCFLTGDEEAQGHLSCGAGCINRML- 1386
              ...||..::.|.. ....:.::|..||.        |||  ..|::...:..|....:.:.|
 Worm    58 WPETATFVTIERNVLGNYISESAKEAIEMGLNRRNKVCCDC--GPDDDCSKNPDCKCYQMGKELQ 120

  Fly  1387 -------------------MIECGPL--CSNGARCTN-------KRFQQHQCWPCRVFRTEKKGC 1423
                               |...||:  ||.|..|..       |...:.......|.|.:.||.
 Worm   121 KYFKSDFLVYGKPVKIMDSMYWDGPMFACSEGCGCRGDCDLNGLKDIDKDHDKKYNVTRRDGKGF 185

  Fly  1424 GITAELLIPPGEFIMEYVGEV----------------IDSEEFERRQHLYSKD---RNRHYYFM- 1468
            .:.....|..|:.::.:.||:                :...|.:.|...:.:|   .|:.|..:
 Worm   186 CLFTMFQIEKGQPVLAFNGEITGYHSINKKPAVEQYALQLSEGDPRLSSFIRDCNVLNKDYKDVL 250

  Fly  1469 --ALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNG----ELRIGFFSVKPIQPGEEITFDY 1527
              ||..:..::...|||.:|:::|:|..|.|..:....|    ::||..|:.:.|..|.|:||
 Worm   251 RNALETKLWVNPLEKGNCARFLSHACQANLELGRVFQGGFSFADVRIVLFAKETIPAGSELTF-- 313

  Fly  1528 QYLRYGRDAQR------CYC-------------EAANCRGWI-GGEPDSDEGEQLDEESDSDAEM 1572
               .||.|.:.      |.|             ..|..|.:: ...|:|:..::..:.|...||.
 Worm   314 ---HYGPDYKEKFLEDLCLCYTCFVPTIVRTSRRIARKRAYVREPTPESERCKRARDRSIIAAET 375

  Fly  1573 DEEELEAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKRKEQTKPKDREYKAGRWLKPSATGSSSS 1637
            .|.|:|   |..:.|.:.||:....||.||..:..|:.:   .|:::.       .|..:.||||
 Worm   376 IEAEIE---EAHEKRMALKARKAFLLKRKLRKSNVRRTE---SPENKR-------SPVQSSSSSS 427

  Fly  1638 AEKPPKKPKVNKFQAMLEDPDVVEELSLLRRGGLKNQQDTLRFSRCLVRAKLLKTRLALLR---- 1698
            :                              |..:....:|| ||..||.   .|||..:|
 Worm   428 S------------------------------GSTEGNVSSLR-SRSDVRK---STRLVGVRSSSS 458

  Fly  1699 --VLTHGELPCRRLFLDYHGLRLLHAWISENGNDDQLREALLDTLESLPIPNRTMLSDSRVYQS- 1760
              |.|:                  ||...:.|  .|....:..||:     .|......|:..|
 Worm   459 ISVATN------------------HAQSQDPG--FQPHSGVTRTLK-----GRFCRQSGRIAVSR 498

  Fly  1761 --VQLWSNSLEQQLAVVPQEKQAALHKRMVALLQKWQALPEIFRIPKRER--------------- 1808
              :||.:|...||..   :...:.:.|....:.:|.:...|:....||.|
 Worm   499 SLLQLRANKRRQQST---EGDASGVRKNEGLVARKERERKELMLFSKRSRPQTCFMGVKSSGRDS 560

  Fly  1809 -IEQMKEHEREAD--------RQQKHVHASTALEDQRERESSNDRFR-QDRFRRDTTSSRIGKPI 1863
             :......|||..        |.:.||..|:.........:|..|.| ..|.|..||.:|:  |:
 Worm   561 SMSSTTSSERERSPSLTESPVRSRNHVRGSSPQSSGLNERASRCRERVTRRTRLQTTPARV--PV 623

  Fly  1864 RMSGNNTICTITTQQKGSNGAPDGMTRNDNRRRSDIGPPSEQRRTLSKELRRSLFERKVALDEAE 1928
            .:...:.|.....|                 |..::..|..:.||.|:
 Worm   624 ELESVSPIPARVRQ-----------------RSPEVQSPKSEMRTRSR----------------- 654

  Fly  1929 RRVCTEDRLEHELRCEFFGADINTDPKQLPFYQKTDTNEWFNSDDVPVPAPPRTELLTKALLSPD 1993
                        .||:  |.|:..|        ::.|.:....|   |...||   :|::..:
 Worm   655 ------------ARCD--GYDVERD--------QSKTGDVVQID---VDGSPR---ITRSHAN-- 689

  Fly  1994 IDVGQGATDVEYKLPPGVDPLPPAWNWQVTSDGDIYYYNLRERISQWEPPSPEQRLQTLLEENTT 2058
             :...|...::.| |...|.:|                :|...|..:.|...|..::.::|....
 Worm   690 -NHPMGHRKIQEK-PIVEDAIP----------------HLEPIIDGYHPERNESVVRDVMEPLDV 736

  Fly  2059 QQPL-----HELQIDPAVLENELIQ---VDTDYVGSLSAKSLAQYIEAKVRERR----------- 2104
            |.|.     |:..:.|.  .|:.::   :.:||...|::.:........:|:.:
 Worm   737 QIPQMNGEHHQTFVSPT--SNKSLRRCGLRSDYSSVLNSPASTSQESTGMRDTQRLNKVLSKNNI 799

  Fly  2105 -DLRRSKLVSIRLISPRRDEDRLYNQLESRKYKENKEKIRRRKELYRRRKIEVLPDAVDEIPVPG 2168
             :|...:|...|::||.|...::.|.::|..:  |...:..::.:..||.|.    .|.|||
 Worm   800 GELESPRLNGTRVLSPPRTRHQISNAIDSDAF--NDMPVLTQEPVQERRMIA----QVFEIP--- 855

  Fly  2169 KALPIQPYLFSSDEEETKVAAIEQPAAEEEQ 2199
                            .|..|..||::...|
 Worm   856 ----------------RKTTAYNQPSSSNSQ 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855
		AWS	1358..1410	CDD:197795	16/88 (18%)
		SET_SETD2	1410..1551	CDD:380949	39/186 (21%)
		WW	2014..2043	CDD:459800	3/28 (11%)
		SRI	2266..2355	CDD:462404
set-19	NP_001379854.1	SET	175..322	CDD:214614	35/151 (23%)