Protein Alignment Set2 and set-5

DIOPT Version :9

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_001256612.1
• Gene: set-5 / 179973
• WormBaseID: WBGene00008145
• Length: 1558
• Species: Caenorhabditis elegans
• Alignment Length: 1476
• Identity: 290/1476 - (19%)
• Similarity: 493/1476 - (33%)
• Gaps: 498/1476 - (33%)

  Fly    77 VRDLLNKNRKAHKIQIEARIDSNPSTGHS-------------------------QSGTTAASTSM 116
            |...|||||:...::. ::.|.:|...||                         :||...:..:.
 Worm   311 VNVFLNKNRQLFLMKY-SKTDKSPLNVHSLDRKTKDYELYLKEQMTKLLAGMPDESGRETSQAAN 374

  Fly   117 STATASAASASSAATV-----SRLFSMFEMSHQSLPPPPPPPTALEIFAKPRPTQS-------LI 169
            .....:|........:     :|:||       .||||||||  ||:..:..|..|       |:
 Worm   375 EVEVQAAMENVEEGEIVPESGNRVFS-------PLPPPPPPP--LEMSRESSPISSVSGKSIKLL 430

  Fly   170 VAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAAIIPTVIVPSCSDSDTNSTSTTT 234
            ..|:                         |....:|:....::.:........:......|....
 Worm   431 TLQL-------------------------KETMHKKNSFFHSSYVKKEETGIINGESIQVTKKAE 470

  Fly   235 SNMSSDSGEL----PGFPIQKPKSKLRVSLKRLKLGGRLESSDSGNSPSSSSPEVEPPALQDENA 295
            |:..|||..:    |....:.|:...:..::|     :..::.||     |..|::.|.....:.
 Worm   471 SSQFSDSSPILLVNPHVHTEAPEPTPKEHMER-----KWSTTHSG-----SMGELQRPVTSQSSR 525

  Fly   296 MDER-PKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEV-EPQDLIDIDMEL 358
            ...| ...|::|.|.:.|..::.:..:...:|:||.  :.||.|:..|.|.| :|:|
 Worm   526 KSSRWDVTEEDLKRKLSATSSTHNPRERASVELETR--QSEEIQKLQRLVNVIKPRD-------- 580

  Fly   359 AKQEPTPDPEEDLDEIMVEVLSGPPSL------W-----SADDEAEEEED--ATVQRATPPGKEP 410
            ...|.|.:.:....||.:|..|..|.|      |     |.||.|:...|  .|..::.|..::
 Worm   581 DSLEGTSNLDAANREIPIEASSTAPLLSRSFQFWRERSKSPDDSAQNHSDLHGTSLKSRPDAQK- 644

  Fly   411 AADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDT 475
              :....|..::....|:|...|...|            .|.:...:|:|
 Worm   645 --NPIPQAVAKTMLKFPVSTLDRPVNT------------KKSMAFGQEAQ--------------- 680

  Fly   476 LSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLN----- 535
                                 ::.:.:..|:.|.:|   .|:|||.|..| |||..|:.|
 Worm   681 ---------------------IMPKSSVFVNNAVKI---PQKFVIVKEAS-SDNPNAAENPVSTQ 720

  Fly   536 -----KDIFEPKVETKATC---GEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKL 592
                 .||.....:.|.|.   |...|..   :||....:.||           |||:::.|
 Worm   721 NTVDLHDIPSKTPQQKVTSENRGSGAPNS---SEDQQKLDEIA-----------PTTQILPE--- 768

  Fly   593 SDEVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPV 657
                          ||             |::.....:.....||:...:.|      |.:.|..
 Worm   769 --------------DP-------------VSVQSRSDVCEVTAETSQKSVGP------ERIGGDA 800

  Fly   658 LLETSLSTEEKSNENVETTPLKTEAAKEDSPPAAPEE-----EASNSSEEPNFLLEDYESNQEQV 717
                     :.|:||  |..::........|...|::     :::.||.|          ||:|:
 Worm   801 ---------QSSSEN--TVSVRNRVDLHGIPSKTPQKLVQSGKSAQSSTE----------NQQQI 844

  Fly   718 ---AEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPAR-------------SSPA 766
               .|..::..|....|.:||:.|    |:|.:.::|:...:.::|.:             .|..
 Worm   845 EMTPEARILSKNPISAQSKTPVKE----ERPESHSLSESFASTQHPMKISEISENSTQNRSDSSR 905

  Fly   767 IVDKKVRAGEMEKKVVKSTKGT------VPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETE 825
            |..:.|:..::..:.:|..:.|      .||.::..:..    |....:.|....:..|.::|.|
 Worm   906 IGLRSVKLEQIPSRTIKVEEPTDFPSNSEPEAQIPLETR----TLEPSEASSVQPEPPIDQEEAE 966

  Fly   826 KEKSSAKLDSSSPNTLDKKGKDTAQWS--PQLQT---LPKSSTKPPQESAPSVISKTTSNQPAP- 884
            .:::...|..:|| |:|   :|.||.|  |....   |||  .:|..|.....:.:.|.....|
 Worm   967 NDENPEILTPNSP-TID---QDEAQNSDAPDASADSDLPK--LEPELERMIDFLVEITEKISVPA 1025

  Fly   885 -----------------KEEQHAAKKGLSDNSPPSVLKAKEKAVSG--------FVECDAMFKAM 924
                             |||  ..::.......|.:.:....::..        .|:.||.|...
 Worm  1026 IKTDIWKLYQARMKQNVKEE--CIRQRFMSKLAPIIHRLDNYSIEARVRIIFVLSVKVDADFLKE 1088

  Fly   925 DLANAQLRLDE---------------------------KNKKK----LKKVP-TKVEAPPKVEPP 957
            ...||.:|:|:                           ||:|:    :|.|. .|.||...|:.
 Worm  1089 LRKNAVVRVDDEQLITKYVSCNDGGLKLEGNHSMSDRLKNRKRSLDLIKDVDCEKKEAEHDVKK- 1152

  Fly   958 TAVPVPGQKKSLSG-------------KTSLRRNTVYEDSPNLERNSS-------PSSDSAQANT 1002
                   .|||.||             ..:.|:..|.|:|.|.:|.||       .||:.:..:.
 Worm  1153 -------TKKSTSGSENDTDAEETDFHSITERQPKVVENSENRKRASSAKRRLVTSSSEESDQDD 1210

  Fly  1003 SAGKLKPSKVKK-KINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTT 1066
            .:.:.|..|.:| ..|.:||:.....:.|..||..|  .||   ..|..::|...:|.:|:|:..
 Worm  1211 RSSRSKTEKQRKIAANEKRSSTASRVRILSDSSDES--NRE---EGPSCSNSKKLTKISGNKKNP 1270

  Fly  1067 SDL------DGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRG 1125
            :.|      |...|.|:...|.|           |.:|:|    ||.:.|            |:.
 Worm  1271 AILRKRLLGDSSDKSDKDERTSC-----------PSSKKR----PKLAEN------------KKN 1308

  Fly  1126 RKEGKESLSRQN-SLDSSSSASQGAPKK--KALKSAEILSAALLETESSESTSSGSKMSRWDVQT 1187
            ..:.|..||..| ..|.:..|.....||  |.:|:.:  .....:...:.:||..|::...|:|
 Worm  1309 ASQPKRCLSGSNVKSDKNEKAGCSGTKKQEKVVKNKK--KPPTPKANENTTTSDHSRIETDDIQ- 1370

  Fly  1188 SPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFA----QRVANMET 1248
               .|...|....|. :..|:.:|               .||.|  |...|..    :.||..:.
 Worm  1371 ---FEGVYPIEPCAP-VSSGMPIL---------------SVKTE--PRSTEHLSFSYENVAYTQA 1414

  Fly  1249 PATTPT---PSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPI 1310
            ..::.|   |.||:         |..|.:..|  .:||                       |..:
 Worm  1415 EFSSTTYACPEPTE---------TISLHDFLT--LLRR-----------------------LLIL 1445

  Fly  1311 SMDEQLAELA-NIEAINE----QFLRSEGLNTFQLLKENFYRCARQ 1351
            ...|:||||| ||:.|:|    :.:.:..:|:  :|...||:..|:
 Worm  1446 LQCEELAELARNIKTISETGGDEKIPTNRINS--VLDVAFYKIQRK 1489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795
		SET	1414..1533	CDD:214614
		PostSET	1535..1551	CDD:214703
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
set-5	NP_001256612.1	SET	36..151	CDD:214614
		PHA03309	<793..1008	CDD:165564	51/255 (20%)
		SPK	1006..1118	CDD:214732	15/113 (13%)
		PTZ00108	<1115..1328	CDD:240271	59/252 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030