DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Set2 and mes-4

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_506333.1	Gene:	mes-4 / 179824	WormBaseID:	WBGene00003222	Length:	898	Species:	Caenorhabditis elegans

Alignment Length:	391	Identity:	105/391 - (26%)
Similarity:	154/391 - (39%)	Gaps:	91/391 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1345 FYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLM--IECGPLCSNGARCTNKRFQQ 1407
            :|:|..::.:.:....|:|  .|.:... .|||      :.|.  .||.|.||....|.|::...
Worm   477 YYKCEPKLEEYHNNEVCNC--EGADRCT-KLSC------QYLADDYECPPSCSKKGVCHNRQVSM 532

  Fly  1408 HQCWPCRVFRTEK--------KGCGITAELLIPPGEFIMEYVGEVIDSEEFERR--QHLYSKDRN 1462
            .       ..:||        ||.|:.|:..|...|:|.|||||:||..|.:||  ....|:|..
Worm   533 G-------IVSEKIKLAATLCKGYGVFAKGQIEKDEYICEYVGEIIDKAEKKRRLDSVSISRDFQ 590

  Fly  1463 RHYYFMALRGEAVIDATSKGNISRYINHSCDPNAET------QKWTVNGEL---RIGFFSVKPIQ 1518
            .::|.|.|.....:||...|||||||||||||||.:      .|.|..|.|   |....:::.|.
Worm   591 ANHYMMELHKGLTVDAARYGNISRYINHSCDPNAASFVTKVFVKKTKEGSLYDTRSYIRAIRTID 655

  Fly  1519 PGEEITFDYQYLRYGRDAQRCYCEAANCRGWIG----GEPD-SDEGEQLDEESDSDAEMDEEELE 1578
            .|:||||.|. :....:...|.|.|.||.|.:|    .:|: :|..|:..:::.|..:...:...
Worm   656 DGDEITFSYN-MNNEENLPDCECGAENCMGTMGKAKREKPEVADSSEKAAKKNKSSKKKSVKNQN 719

  Fly  1579 AEPEEG------------QPRKSAKAKAKS------------------KLKAKLPLA-TG----- 1607
            .:.:|.            .|.|.:.:.|.|                  |..:..|:| ||
Worm   720 RKSQEAGKNGTASKKSEISPSKPSTSSASSTSFVQQASWPISQNKKNLKKNSNQPVADTGSTLST 784

  Fly  1608 -------RKRKEQTKPKDREYKAGRWLKPSATGSSS-----SAEKPPKKPKVNKFQAMLEDPDVV 1660
                   .|.:|...|.....:|.....|.|..|.|     .:|.||.|......|.:.|....:
Worm   785 STELNFHEKPQELLSPVSSRSRAASSSTPRAQKSKSRRDDVESEAPPVKRATPSLQTIQETGKAI 849

  Fly  1661 E 1661
            |
Worm   850 E 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	14/53 (26%)
		SET	1414..1533	CDD:214614	53/137 (39%)
		PostSET	1535..1551	CDD:214703	6/15 (40%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
mes-4	NP_506333.1	PHD_SF	207..269	CDD:304600
mes-4	NP_506333.1	SET	537..671	CDD:214614	53/134 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040