Protein Alignment Set2 and set-26

DIOPT Version :9

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_001370101.1
• Gene: set-26 / 178463
• WormBaseID: WBGene00013106
• Length: 1645
• Species: Caenorhabditis elegans
• Alignment Length: 1412
• Identity: 274/1412 - (19%)
• Similarity: 469/1412 - (33%)
• Gaps: 491/1412 - (34%)

  Fly     2 EESGPPSNPSPVASRGRGRGRPPKVALSALGNTPPHINPSLKHADA--EASPTAPEDQDSGQSEC 64
            :::.||..|.|         .||.:.|     .|.|.:.:|....:  |:.|..|:..
 Worm   587 QDAAPPHVPPP---------PPPPLVL-----RPHHQDETLAMVQSVFESKPRQPDTP------- 630

  Fly    65 RRSSRKKIIKFDVRDLLNKNRKAHKIQIEARIDSNPSTGHSQSGTTAASTSMSTATASAASASSA 129
              ..::.|.|  :.|||             |..::..||  |||::||: ...|.:.|||.|.:
 Worm   631 --KDKEAISK--IADLL-------------RFSADEFTG--QSGSSAAA-RQRTVSGSAARAQT- 674

  Fly   130 ATVSRLFSMFEMSHQ---------------------------SLP----PPPPPPTALEIFAKPR 163
                     ::|.||                           ::|    ||||||:..:
 Worm   675 ---------YQMHHQQQQQHHHQMPMDQRKRHSSGRYDALMGAMPLQQQPPPPPPSQFQ------ 724

  Fly   164 PTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAAIIPTVIVPSCSDSDTN 228
            .|.|:              ||             |.||||:.::....|:.|
 Worm   725 HTDSI--------------AH-------------RPRGRPKGTRHPSVAVQP------------- 749

  Fly   229 STSTTTSNMSSDSGELPGFPIQKPKSK-LRVSLKRLKLGGRLESSDSGNSPSSSSPEVEPPALQD 292
                   ..|..:..||      |::: :.:|.:.   |...::|||                 :
 Worm   750 -------QRSGGARTLP------PRAQTVAMSARN---GANAKNSDS-----------------E 781

  Fly   293 ENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDLIDIDME 357
            ...:||..::...: |.....::.|.|:      ||.|..|             ..|.:..:.:.
 Worm   782 SEGIDEAAEESWTM-RCHCGMDHGDGDT------IECEGCK-------------TWQHMACMGLT 826

  Fly   358 LAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGK------EPAADSCS 416
            |.........|..|          |..|..:..||..|::..:.|.....|      ||......
 Worm   827 LKSNTSKYKCEMCL----------PRRLPVSKAEAAREQERILNRLRAAAKKQKRKSEPVEQKQK 881

  Fly   417 SAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLSESEV 481
            |.|..||:|||::...:..:.......:.:.::|..:...|::...:..     |.|..|.:...
 Worm   882 SQPSTSRKSAPMALQQQPAEPRVAQLNDYSKQASALLFGMEQTAGADTL-----LAESRLHKKAR 941

  Fly   482 TSSVSPTIEHMV------VEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFE 540
            ...|...:|.:|      :.:|::|.|..|..::|:  .:|......:|.....:..:..:|:.:
 Worm   942 RMFVEEAVEALVTTDLVQIRQVILEVNGHVSMSNEV--KRQPGGGNCIFMYDGLMKGTAGEDMGD 1004

  Fly   541 PKV-----------ETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSD 594
            .:.           :||.|....|  |..|.:.|.   |..|||....|.||..|.       :.
 Worm  1005 GQELVCIDTKRKGNDTKFTRRSCV--PNCVLKHVL---GSNATLGIMIVATKDITR-------NT 1057

  Fly   595 EVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLL 659
            ||.    |..::|.:::||||..::....:                     :.|..||.......
 Worm  1058 EVT----LPFDADWRESEVELECAEHMKEL---------------------QACPFESERRRFAA 1097

  Fly   660 ETSLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMK 724
            |...:.:.|..|                     .|||..:.||...|.|  |..:|:.|:.:
 Worm  1098 ERHRAMDHKKRE---------------------AEEARRADEERRRLEE--EVRRERAAKTK--- 1136

  Fly   725 CNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTV 789
                         :|.|.||...|.    |||.|...::.     ::..|.|.:|..|:::....
 Worm  1137 -------------QMDEAEKARLEA----EKAAEKEKKAK-----EREEAKERKKMEVEASAAAA 1179

  Fly   790 PEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSS--PNTLDKKGKDTAQWS 852
            ||       |..::| |:::...:.|:|...::|.|.::..|:..|.|  |..|:..|....:.:
 Worm  1180 PE-------SSNSIT-AREERRIQQAEEMFRRQEEEGKRKEARRRSKSVTPGVLEAAGTAAREDA 1236

  Fly   853 PQLQTLPKSSTKPP--QESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFV 915
            |: .::|..:..||  :.|.......:||:...|.|             ||:
 Worm  1237 PE-ASIPAPAPSPPASRRSVSRTTQPSTSSFATPTE-------------PPA------------- 1274

  Fly   916 ECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTV 980
                                |||:....|      |||.||            .|....:|..||
 Worm  1275 --------------------KNKRMRSVV------PPKSEP------------ASSAKRVRATTV 1301

  Fly   981 YEDSPNLERNSSPSSDSAQANTSA-GKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREV- 1043
              .:|   ::::.|:||.:..:|| ||...:|..|.:.|....:....|:||..:..||....:
 Worm  1302 --ATP---KDTTASNDSRKRKSSATGKTPVAKRSKNVVPTSFGLALIEKELREQARDSTVLEMIL 1361

  Fly  1044 -------------AASSP-----------VSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICE 1084
                         |..||           .:...:..:||...|:.........|.:.|:    |
 Worm  1362 PDYIMKEKRSGLLAGQSPDFSEVRAQIEEENRMKERFTKREAKKKAVEKAKEKEKKEHRK----E 1422

  Fly  1085 DRQPETAIPVPLTKR-------RFSMHPKASANPLHDTLLQTAGKKRGRK-EGKESLSRQNSLDS 1141
            .::.....|.|.:::       :....||:...|   ....||.|...:| |..:.:.|:.| :|
 Worm  1423 PKKANEPGPAPKSEKAVEKAVEKVEKKPKSPQKP---PAKPTAQKPPLKKTEEVDGIEREAS-ES 1483

  Fly  1142 SSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIED 1206
            ||..|..||::|  |:.:.::.|...:..|:...:|      :..|.|.:....       ||..
 Worm  1484 SSKESSVAPEEK--KNPKKITFAEYNSRRSQKREAG------ECSTPPAVTRRG-------FIPS 1533

  Fly  1207 GVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTV 1271
                           .||:|                :.|:|..|......|:.||   :|.|||:
 Worm  1534 ---------------TEGED----------------LVNVELSAIPLDDHPSSSN---TAPTTTI 1564

  Fly  1272 LKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPISMDEQLAE 1318
            ...:  ||..:.:..:.:.|.  ..|:.||.||.     |:|:..||
 Worm  1565 APSV--GGAPKPTSVVVKSPS--TRSRTRGAASE-----SVDDAPAE 1602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795
		SET	1414..1533	CDD:214614
		PostSET	1535..1551	CDD:214703
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
set-26	NP_001370101.1	PRK03427	<9..>135	CDD:235124
		PHD_Bye1p_SIZ1_like	796..839	CDD:277045	10/61 (16%)
		SET_SETD5-like	935..1067	CDD:380927	30/149 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030