Protein Alignment Set2 and set-21

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_500555.2
• Gene: set-21 / 177204
• WormBaseID: WBGene00021282
• Length: 568
• Species: Caenorhabditis elegans
• Alignment Length: 526
• Identity: 103/526 - (19%)
• Similarity: 193/526 - (36%)
• Gaps: 109/526 - (20%)

  Fly  1122 KKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALK-SAEILSAALLETE------SSESTSSGSK 1179
            :|...|..|.|:...:  |.||:|.....:.||:: ..:...|..:||:      |::.||...:
 Worm     6 EKLKSKAQKRSIGEND--DKSSNAEPPRKRSKAMRLPTDDEDAKYVETKRALKKYSADKTSEMLR 68

  Fly  1180 MSRWDVQTSP-ELE----------AANPFGDIAKFIEDG------------------VNLLKRDK 1215
            :.::..:..| :||          ..:.:.|..:.::|.                  :|||:|.:
 Worm    69 VIKFAFKAPPFKLELPVYLRYSSYQLSSYRDRCQLLKDNSELTRINVEPNIITLNAHLNLLERIR 133

  Fly  1216 VDEDQRK--EGQDEVKREADPEEDEFAQRVA------NMETPATTPTPSPTQSNPEDSASTTTVL 1272
            .|.:...  |.|:...::........|||:.      |:.........:.|:..||.........
 Worm   134 DDPELNTYYEYQETENKDLGRCMRFIAQRIVMARTNNNLMKHLLAEQGTSTEITPESLQEYFPAY 198

  Fly  1273 KELETGGGVRRSHRIKQKPQGPRAS--QGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGL 1335
            :..:....::.:....:....|..|  :|..:.|:.: |:::.....::..::...|..| ::.:
 Worm   199 EPPKNRIRIKSNLTFNENDVIPVYSDLEGETLESLEI-PVTLTYDYTDVNMVDQFTEPNL-TKAI 261

  Fly  1336 NTFQLLKENFYRCARQVSQ------ENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLM------- 1387
            ...:...||..||....|:      ||.  :|.||:. ::..||......||......
 Worm   262 IMSEENGENMIRCTCCSSKPIVPCYENE--KCPCFIM-NQRMQGFQIPREGCGKTEFTSFKPIYF 323

  Fly  1388 ------------IECGPLCSNGARCTNKR--FQQHQCWPCRVFRTEKK-GCGITAELLIPPGEFI 1437
                        ..|..||..|.:|||..  ....:.:|..::|.:.. |..:.:.::||.|..:
 Worm   324 FNPKDHYYDHAGFACSELCGCGGKCTNNSMLLPHKKLFPLEIYRNDPAVGFVVRSTVMIPAGTPL 388

  Fly  1438 MEYVGEVID--SEEFERRQHLYSKDRNRHYYFMAL------------------RGEAVIDATSKG 1482
            ||:.||:::  :.|.:.|.:.|....:....|..|                  |....||....|
 Worm   389 MEFTGEIVELKNMELDNRDYAYQITYSDDVKFRRLLQEVKFSKEYTKLLEKLSRKRFFIDPKIHG 453

  Fly  1483 NISRYINHSCDPNAET----QKWTVNGELRIGFFSVKPIQPGEEITFDY--QYLRYGRDAQRCYC 1541
            |::|.:.|:|.||.|.    ||......|.:...:::.:.|...:|.||  .|....:|  ||.|
 Worm   454 NVARTVGHACAPNMEVVRVFQKSLSPAHLHLVLVTLEDVFPSVPLTIDYGKTYTDVLKD--RCRC 516

  Fly  1542 EAANCR 1547
            ....||
 Worm   517 RTFACR 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855
		AWS	1358..1410	CDD:197795	14/72 (19%)
		SET_SETD2	1410..1551	CDD:380949	40/165 (24%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
set-21	NP_500555.2	SET	<336..503	CDD:394802	39/166 (23%)