DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Set2 and set-16

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:NP_499819.3 Gene:set-16 / 176802 WormBaseID:WBGene00011729 Length:2475 Species:Caenorhabditis elegans


Alignment Length:2063 Identity:370/2063 - (17%)
Similarity:622/2063 - (30%) Gaps:769/2063 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MEESGPPSNPSPV-ASRGRGRGRPP-KVALSALG------NTPPHINPSLKHADAEASPTAPEDQ 57
            :|:|.....|.|: ..||||||.|. :..::.:|      ..|.|   .::....||:..|...:
 Worm   668 LEDSSDQVTPLPIPGQRGRGRGNPSGRRGMNRIGIGGFYAKLPRH---RIQALTEEAAAAAASSE 729

  Fly    58 DSGQSECRRSSRKKIIKFDVRDLLNKNRKAHKIQIEARIDSNPSTGHSQSGTTAASTSMSTATAS 122
            ||.|::..|.||:..::           .|:..||:          .:..|..|....:...|  
 Worm   730 DSKQAKRPRKSRRSQLE-----------DAYPPQIQ----------EAFFGIKAVEGKVLVDT-- 771

  Fly   123 AASASSAATVSRLFSMFEMSHQSLPPPPPPPTALEI---FAKPRPTQSLIVAQVTSEPSAVGGAH 184
                                      |...|...|.   :.:.|.|::..:....||        
 Worm   772 --------------------------PVDEPFLAEFNGWYKRTRSTKAFELCMTASE-------- 802

  Fly   185 PVQTMAGLPPVTPRKRGRPRKSQLADAAIIPTVIVPSCSDSDTNSTSTTTSNMSSDSGELPGFPI 249
                         ..|....:::..|...:|.:...:..|.|.|.              |..|.:
 Worm   803 -------------MLRTDIDENEFLDCVGLPNMETDALDDFDFNL--------------LEDFDV 840

  Fly   250 QKPKSKLRVSL-----------------------KRLKLGGRLESSDSGNSPSSSSPEVEPPALQ 291
            .:...:|..||                       ....|..|..:|.:|.|..|..|  ..|.:.
 Worm   841 DEENDELENSLLGAPGNTEMKEDAAEGIEGSYGPTSFNLDQRPSTSSAGGSLGSQDP--FHPGMN 903

  Fly   292 DENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDL----- 351
            ..|.....|.....::|.....:||                  |..|...|..|.||..|     
 Worm   904 PANFAQHAPGVRNAIARSGSQTDNS------------------ERYQFSARWEEDEPNGLQATTA 950

  Fly   352 -------------------IDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEED 397
                               :|...::.|...|.:.|..||.:               :.|.:...
 Worm   951 AVLYSNEKHGYLRQQFPNWVDRVKQIQKLWRTLNHEVRLDYV---------------NRARDNRT 1000

  Fly   398 ATVQRATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQ 462
            .:..|..|  :.....|..|.|      .|..|            .::.|..|..::.:.|...|
 Worm  1001 RSGNRPRP--RRTNVQSTDSPP------PPQMG------------FKVPANPSSNMMGSSEQSMQ 1045

  Fly   463 EEQ-----HILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKK 522
            .:|     |:.:|:.:                        |.::.:.|....|.|:...|..:.|
 Worm  1046 PKQVFITHHLPMDVYQ------------------------VYQDLKRVKFDRERLNGSLEEQLNK 1086

  Fly   523 VFSESDNIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEG---IAATLEKSAVVTKPTT 584
            ...:..|:||...:.:   |.:|.|        |:....::.:.|.   ..|||.:...||:...
 Worm  1087 ARKQKKNLAAKKRQMV---KTQTAA--------PDYDGRNIDLNESDQQTLATLTEQIKVTQAEI 1140

  Fly   585 EMIA------ETKLSDEVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTS---- 639
            |:..      |:.|||.|:....|::|.:.|:.:|:|...:.......::.:|:.:.:...    
 Worm  1141 ELHRRDLKKHESNLSDFVMKHGILRNEHEVKREDVQLSAIRDQQYAAHADEMLAQQAQNQGLGQV 1205

  Fly   640 --SPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEE 702
              ..||.|:.    ::|.|:|.:.....:......:...| ..:......||..|:....|....
 Worm  1206 HPPVLVAPQA----AISLPMLNQQQQHHQRMMQMQMRGGP-PGQFMMRAQPPQQPQINMHNHEIA 1265

  Fly   703 PNFLLEDYES------------------------------NQEQVAEDEMMKCNNQK-------- 729
            ...|::.:.:                              :...|||.|.|:...|:        
 Worm  1266 KRMLMQQFRNAHPVMGGIRHDEITDPIMRDVYDCLEAIVFDVHTVAEREAMQAAGQQPPPPHIMQ 1330

  Fly   730 ------------------GQ----------KQTPLPEMKEPEKPVAETVSKKEKAMENP---ARS 763
                              ||          :|.|..::.:.:....:|.:|::|...||   |.|
 Worm  1331 RMMQQHPGGPGGPRLIMPGQFPQLQGRRIPQQPPPVQLPQVDVDPPKTAAKRKKGGGNPKKNASS 1395

  Fly   764 SPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKES--GKSAKEAI------- 819
            .||       |||.:..:         |:.....:.|..: |.||||.  .:...|.:       
 Worm  1396 YPA-------AGEYDAWI---------EQMRMRFRLCPDI-PKKQKEPRLNRPGCEFVSHGLTDM 1443

  Fly   820 ----LKKETE--------KEKSSAKLDSSSPNTLDKKGKDTA--------QWSPQLQ-------T 857
                .||.|.        :.|...:|..:     :::|:.:.        |..||::       .
 Worm  1444 AVRATKKRTPLVGEFGAMRVKRGTRLFGN-----EERGEKSIMFQDLNLYQVEPQIRLFALYNNP 1503

  Fly   858 LPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSD------------NSPPSV------- 903
            ||.......::....:|.|.||.......::..| .|..|            |.||:.       
 Worm  1504 LPTMEDDVFRDEEDQIIDKPTSALQKLLNKKRGA-SGAMDHIRSRARYMEETNIPPAPERGMFYE 1567

  Fly   904 -LKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNK---------KKLKKVPTKV-----EAPPK 953
             ::|:|:     |..:.:|...|:.. :..:|||..         :.|..:..:|     :.||:
 Worm  1568 NVEAEEE-----VTVELVFNTCDITE-ESSVDEKKDVCGRLHEQIRDLLAIKDEVAWSMEDTPPE 1626

  Fly   954 ------VEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKV 1012
                  .||...|....|..|.|...|  ..|..|....:|..::|.:...:...    ::||:.
 Worm  1627 SPVSRSPEPEATVGAVQQTSSTSRAPS--EATEREIKREVEEEAAPVAPEIKREI----VEPSQS 1685

  Fly  1013 KKKINPRRSTICEAAKDLRSSSSSST---------PTREV--------------AASSPVSTSSD 1054
            :   |..:...|:.|.:..||:|..|         ||..|              |..:|::.|.:
 Worm  1686 Q---NSSQCKNCQKALESHSSTSIVTVKAEKLNLAPTGSVVTTRAAPVPPGVPGAPGAPIAPSEE 1747

  Fly  1055 SSSKRNGSKRTTSDLDGGSKLDQRRYTICEDR---QPETAIPVPLTKRRFSMHPKASANPLHDTL 1116
            .:.:...|                   .|..:   :..:|...|||:...:...:..:..:::.|
 Worm  1748 KTKEELAS-------------------FCSKKCYYELASATRAPLTEEEVAAAEQHVSEEVYNKL 1793

  Fly  1117 LQ----------TAGKK----------------RGRKEGKESLSRQNSLDSSSSASQGAPKKKAL 1155
            .|          :.|||                .||:| ..::....||..:..|.:.||.::|.
 Worm  1794 KQVLTENIVKAVSQGKKPDPQLTSPRDTRCMMDEGRRE-NVTIVPVASLIGAVEAPKEAPSQRAA 1857

  Fly  1156 KSAE-----------------------ILSAAL--------LETE---------SSESTSSGSKM 1180
            ::||                       |||..:        |:..         ..|:|..|..:
 Worm  1858 EAAEDWKAYTKSIWDSFVNIQQQHAHHILSPKIGVPHPPYHLDKRICVFCGGIGDGETTRCGRLI 1922

  Fly  1181 S------------RWDVQTSPE------------LEAANPFGDIAK------------------- 1202
            |            .|..:....            |.||....|..|                   
 Worm  1923 SLTEFYWVHVNCALWSAEVFENQTGGLTNVDRAVLRAAQTACDHCKRPGASVKCHKMNCGVNYHV 1987

  Fly  1203 ---------FIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANMETPATTPTPSPT 1258
                     ||:|...:.|:.:...:|...|:.:..|....:.||     ..|.|.....|..||
 Worm  1988 LCAMQNNGFFIKDRTFICKQHEKVSNQAIVGRLDALRRIYVKRDE-----NTMLTRLFELTDGPT 2047

  Fly  1259 Q-------SNPEDSASTTTVLKELETGGGV-RRSHRIKQKPQGPRASQGRGV------------- 1302
            .       :..:..:.|...||...|...: ..::||.:....|::.:.|.:             
 Worm  2048 LCMRLGAFTFYKIGSITPKQLKRFHTKDYIFPNNYRITRLFWSPKSHRERMMFECIIEDRNNQPI 2112

  Fly  1303 -----------------ASVALAPI-SMDEQLAELANIEAINEQFLRSE-------GLN------ 1336
                             ||.|..|| ....||.|....:::  :|..|:       |||      
 Worm  2113 FVVKSLEDPTICYKAVSASKAWQPIYEKVHQLREQQQGDSL--KFFGSQICGETLFGLNENAITK 2175

  Fly  1337 ------------TFQ-----------LLKENFYRCARQVSQENAEMQCDCFLTGDEEAQG---HL 1375
                        |:|           .|.||...|||...:.....|  .|.|..:...|   |:
 Worm  2176 ITESLPGFDTIFTYQHRHQNSPVLELPLAENLMGCARAEPRNRTIGQ--HFRTKPQPMGGTHHHI 2238

  Fly  1376 SCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQC------------------------------ 1410
            ...:|..::..:|      ::.:...|:..|..|.                              
 Worm  2239 GSASGLSSQATII------ASSSSSANESLQSRQAATSVTSANSGRTRGVRSYYTEEAAARARAF 2297

  Fly  1411 --------------------------------WPCRVF--RTEKKGCGITAELLIPPGEFIMEYV 1441
                                            |..||:  |:...|.|:.|::.|..|:||:||.
 Worm  2298 GIPPEMASLSLRMETTQNAQTAFSAYQKMRREWKDRVYLARSRIAGLGLYAKVDISMGDFIIEYK 2362

  Fly  1442 GEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNG- 1505
            ||:|.||..|.|:..|.. :||..|...:..|.|||||..|..:||||||||||..||...... 
 Worm  2363 GEIIRSEVCEVREIRYVA-QNRGVYMFRIDEEWVIDATMAGGPARYINHSCDPNCSTQILDAGSG 2426

  Fly  1506 --ELRIGFFSVKPIQPGEEITFDYQY-LRYGRDAQRCYCEAANCRGWI 1550
              |.:|...:.:||...||:|:|||: |....|...|.|.|.||..|:
 Worm  2427 AREKKIIITANRPISANEELTYDYQFELEGTTDKIPCLCGAPNCVKWM 2474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 9/54 (17%)
SET 1414..1533 CDD:214614 53/124 (43%)
PostSET 1535..1551 CDD:214703 7/16 (44%)
WW 2014..2043 CDD:278809
SRI 2270..2348 CDD:285448
set-16NP_499819.3 PHD_SF 42..84 CDD:276966
PHD4_KMT2C_like 427..477 CDD:276987
PHD5_KMT2C_like 479..524 CDD:276988
PHD6_KMT2C_like 554..604 CDD:276989
DUF1351 1060..>1163 CDD:284492 25/137 (18%)
ePHD2_KMT2C_like 1904..2008 CDD:277136 14/103 (14%)
FYRN 2055..2104 CDD:283589 8/48 (17%)
FYRC 2112..2199 CDD:197781 15/88 (17%)
SET 2333..2457 CDD:214614 53/124 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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