Protein Alignment Set2 and set-2

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_498039.1
• Gene: set-2 / 175662
• WormBaseID: WBGene00004782
• Length: 1510
• Species: Caenorhabditis elegans
• Alignment Length: 1729
• Identity: 340/1729 - (19%)
• Similarity: 536/1729 - (31%)
• Gaps: 632/1729 - (36%)

  Fly    36 PHINPSLK--------HADAEASPTAPEDQDSGQSECRRSSRKKIIKFDVRDLLNKNRKAHKIQI 92
            |.|:|.|.        ..:.:..|..|:|..|......|..|...:    ||      :..|.::
 Worm   199 PRIDPFLSILNEEYEVATNGQVLPILPDDLASIDPSVLRDLRANFL----RD------QNEKYEL 253

  Fly    93 EARIDSNPSTGHSQSGTTAASTSMSTATASAASASSAATVSRLFSMFEMS-------HQSLPPPP 150
            ..|      ..:...|...:...|.|:.......:....|..  |..:||       .:..||||
 Worm   254 AMR------NTYEDEGGMLSGVIMDTSDHYERDYTMDHDVGP--SSMKMSPIPPPPIKEESPPPP 310

  Fly   151 PPPTALEIFAKPRPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAAIIP 215
            |||                               ||.:::.|.||                   |
 Worm   311 PPP-------------------------------PVASVSNLAPV-------------------P 325

  Fly   216 TVIVPSCSDSDTNSTSTTTSNMSSDSGELPGF-PIQKP---------KSKLRVSLKRLKLGGRLE 270
            :|.:|.     .|:...::|.|     .:|.| |.:.|         :|..|.||.|.:...|..
 Worm   326 SVQLPY-----YNNIQPSSSTM-----HMPEFRPTEPPPSYSREDPYRSTSRSSLSRHRNRSRSP 380

  Fly   271 SSDSGNSPSSSSPEVEPPALQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGE 335
            |.....|..|||....           .||:..       :..:|::.|    .::.||...:..
 Worm   381 SDGMDRSGRSSSRRTH-----------RRPESR-------NGSKNANGD----VVKYETYKMEKR 423

  Fly   336 EEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATV 400
            :.:.||...:.|       .:.:.::......:..|:.:..|..||..|:.:..|.::||.....
 Worm   424 KIKYEGGNKKYE-------QVHIKERTAVIRGKNQLENVSSESASGSSSVDTYPDFSDEERKKKK 481

  Fly   401 QRATP--PGKEPAA---DSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQ 460
            :..:|  ..|:..|   ||...:...:||..  ||.| |.::.|..|...::.|:::.|.:..:.
 Worm   482 RPKSPNRSKKDSRAFGWDSTDESDEDTRRRR--SGRS-QNRSSERKFQTTSSSSTRRELSSTHTN 543

  Fly   461 DQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFS 525
            ....            .:|..|....|...|
 Worm   544 SVPN------------LKSHETPPPPPPKGH---------------------------------- 562

  Fly   526 ESDNIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAET 590
                           |.|..:.....|  :|:|:....|       .|....:...|.|..:
 Worm   563 ---------------PSVHLQTPYQHV--QPQMIPATYY-------NLPPQHMAPPPITTSL--- 600

  Fly   591 KLSDEVVIEPPLKDESDPKQ---------TEVELPESKPAVNIPKSERI----LSAEVETTSS-P 641
                     ||..|.|.|..         |...||....|.|||:...:    |||..|..|| |
 Worm   601 ---------PPFCDFSQPPPGFTPTFKPITNAPLPTPYQASNIPQPGLVQIAALSAAPEPFSSIP 656

  Fly   642 LVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSP--------------PAAP 692
            ..||         ||                   .|::.:..:.:||              |...
 Worm   657 GPPP---------GP-------------------APIQEDVGRAESPEKPSLSERFSGIFGPTQR 693

  Fly   693 EEEAS-----------NSSEEPNFLLEDYE----SNQEQVAEDEMMKCNNQKGQKQTPLPEMKEP 742
            ||.|.           :.|.:....|||.:    |:.|.|:..|.::|             |:|
 Worm   694 EEPAQVEVEYDYPLKHSESHDDRHSLEDMDVEVSSDGETVSNVEKIEC-------------MEE- 744

  Fly   743 EKPVAETVSKKEKAMENPARSSPAIVD--KKVRAGEMEKKVVKSTKGTVPEK---KMDSKKSCAA 802
                     ||.:.:|..|.:...||.  ||....|:.:||.:..:..:..:   .:|.|....|
 Worm   745 ---------KKRQDLERIAIARTPIVKKCKKRMMDELSRKVAEDIRQQIMRQCFAALDEKLHLKA 800

  Fly   803 VTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQ 867
            :.   .:|..|..:|...::|.||..:....|.....||...           |:...||....:
 Worm   801 IA---DEEKRKKEREEKARQEAEKPSNHLIADMMPSQTLYNN-----------QSFASSSRGFYR 851

  Fly   868 ESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLR 932
            :..|  |.|   :.|..:|..|.||
 Worm   852 KQKP--IPK---SHPKHQEHHHHAK---------------------------------------- 871

  Fly   933 LDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDS 997
                                     .:|..|....|.|..:|:        :|..:|..|.||.|
 Worm   872 -------------------------ASVSTPVHSSSTSRNSSV--------APTPQRTVSTSSSS 903

  Fly   998 AQANTSA--------GKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSD 1054
            :.|.|||        ....|.:|::    |::::....|..|.:|.|||..:    |||......
 Worm   904 SSAATSARVSEDESDSDSTPGEVQR----RKTSVLSNDKRRRRASFSSTSIQ----SSPERQRDV 960

  Fly  1055 SSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQT 1119
            |||.|..|..:||.:                :|.||| .....||:..|....|:.
 Worm   961 SSSSRTSSSSSTSSM----------------KQEETA-DEKSRKRKLIMSSDESST--------- 999

  Fly  1120 AGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWD 1184
                .|........|||:||:.....:.|.|.||. ...:.:|..:.:.|..|
 Worm  1000 ----TGSTATSVVSSRQSSLEPQQEKTDGEPPKKK-SQTDFISERVSKIEGEE------------ 1047

  Fly  1185 VQTSPE-LEAANP-FGD-------IAKFIEDGV-------NLLKRDKVDEDQRKE---GQDEVKR 1230
             :..|| :|.:.| .||       |..:.:.|:       |.::..:......:.   |.|:.::
 Worm  1048 -RPLPEPVETSGPIIGDSSYLPYKIVHWEKAGIIEMNLPANSIRAHEYHPFTTEHCYFGIDDPRQ 1111

  Fly  1231 EADPEEDEFAQRVANMETPATTP---TPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQ 1292
               |:...|.......| |.:.|   ||:|.  .|.|:.:.|..|..::.....:...: ||||:
 Worm  1112 ---PKIQIFDHSPCKSE-PGSEPLKITPAPW--GPIDNVAETGPLIYMDVVTAPKTVQK-KQKPR 1169

  Fly  1293 ----------------------GPRASQGRGVASVALAPISMDEQ------LAELANIE------ 1323
                                  .||..:       ...|.|.:|:      ..:|.::|
 Worm  1170 KQVFEKDPYEYYEPPPTKRPAPPPRFKK-------TFKPRSEEEKKKIIGDCEDLPDLEDQWYLR 1227

  Fly  1324 -AINE--------------------QFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTG 1367
             |:||                    :.||||.    .||:.|..|..:.:.        |.|..
 Worm  1228 AALNEMQSEVKSADELPWKKMLTFKEMLRSED----PLLRLNPIRSKKGLP--------DAFYE- 1279

  Fly  1368 DEEAQGHLSCGAGC--------------------------------------------------- 1381
            |||..|.:...|||
 Worm  1280 DEELDGVIPVAAGCSRARPYEKMTMKQKRSLVRRPDNESHPTAIFSERDETAIRHQHLASKDMRL 1344

  Fly  1382 INRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVID 1446
            :.|.|:...|...::..:....:|::..   .:..|:...|.|:.|...|.|.|.|:||:|:.|.
 Worm  1345 LQRRLLTSLGDANNDFFKINQLKFRKKM---IKFARSRIHGWGLYAMESIAPDEMIVEYIGQTIR 1406

  Fly  1447 SEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGF 1511
            |...|.|:..|.:......|...:....|||||.:||.:|:|||||.||...:..|:.||.||..
 Worm  1407 SLVAEEREKAYERRGIGSSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVI 1471

  Fly  1512 FSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWI 1550
            :|...|:.|||||:||:: ....|...|.|.|..|||::
 Worm  1472 YSRTIIKKGEEITYDYKF-PIEDDKIDCLCGAKTCRGYL 1509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	28/131 (21%)
		AWS	1358..1410	CDD:197795	13/102 (13%)
		SET_SETD2	1410..1551	CDD:380949	53/141 (38%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
set-2	NP_498039.1	RRM_SF	124..213	CDD:473069	4/13 (31%)
		SET_SETD1	1359..1506	CDD:380946	51/150 (34%)