Protein Alignment Set2 and mes-2

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_496992.3
• Gene: mes-2 / 175096
• WormBaseID: WBGene00003220
• Length: 773
• Species: Caenorhabditis elegans
• Alignment Length: 875
• Identity: 184/875 - (21%)
• Similarity: 298/875 - (34%)
• Gaps: 239/875 - (27%)

  Fly   757 MEN--PARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAI 819
            |.|  |:.|:|:...|| |..:.|..:.||.|          .|:.......:...|.:..||.:
 Worm     1 MSNSEPSTSTPSGKTKK-RGKKCETSMGKSKK----------SKNLPRFVKIQPIFSSEKIKETV 54

  Fly   820 LKKETEKEKSSAK------LDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTT 878
            .::..|:.|...|      .|.......|:...|...|.              ::::.||
 Worm    55 CEQGIEECKRMLKGHFNAIKDDYDIRVKDELDTDIKDWL--------------KDASSSV----- 100

  Fly   879 SNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKK 943
                  .|.:...::.|.:..  ::.|...|....:.|.|  :|..|.....::.|...:..|.|
 Worm   101 ------NEYRRRLQENLGEGR--TIAKFSFKNCEKYEEND--YKVSDSTVTWIKPDRTEEGDLMK 155

  Fly   944 VPTKVEAP------PKVEPPTAVPVPGQKKSLSGKTSLRRNTV------YEDSPNLERNSSPSSD 996
               |..||      ..:.||....|| .::|::....||...:      .:|....|.......|
 Worm   156 ---KFRAPCSRIEVGDISPPMIYWVP-IEQSVATPDQLRLTHMPYFGDGIDDGNIYEHLIDMFPD 216

  Fly   997 SAQANTSAGKLKPSKVKKKINPRRSTICEAA-KDLRSSSS-----------SSTPTREVAASSPV 1049
            .....:.........:..|       :|.|| ||.:.|..           :.:..||.:::.||
 Worm   217 GIHGFSDNWSYVNDWILYK-------LCRAALKDYQGSPDVFYYTLYRLWPNKSSQREFSSAFPV 274

  Fly  1050 STSS------DSSSKRNGSKRTTSDLDGGSKLDQ------RRYTICEDRQPETAIPVPLTKRRF- 1101
            ...:      |.||.....|  |...:|...|..      ..|| |.....:..||:......|
 Worm   275 LCENFAEKGFDPSSLEPWKK--TKIAEGAQNLRNPTCYACLAYT-CAIHGFKAEIPIEFPNGEFY 336

  Fly  1102 -SMHPKASANPLHDTLLQTAG--KKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKS------ 1157
             :|.|..: ||.:|..:.:..  |....||..|.|     :..|....|...|...:||
 Worm   337 NAMLPLPN-NPENDGKMCSGNCWKSVTMKEVSEVL-----VPDSEEILQKEVKIYFMKSRIAKMP 395

  Fly  1158 ----AEILSAALLET-------------ESSESTSSGS-------KMSRWDVQTSPELEAANPFG 1198
                |.|::..:..|             |..|.:...|       .||..:..::..|:...|..
 Worm   396 IEDGALIVNIYVFNTYIPFCEFVKKYVDEDDEESKIRSCRDAYHLMMSMAENVSARRLKMGQPSN 460

  Fly  1199 DIAKFIEDGVNLLKRDKVDED--QRKEGQDEVKREA-----DPE----EDEFAQRVANME---TP 1249
            .::  |:|.||..:|:::.::  :||...|.::.:|     |.|    ||:......|.|   ..
 Worm   461 RLS--IKDRVNNFRRNQLSQEKAKRKLRHDSLRIQALRDGLDAEKLIREDDMRDSQRNSEKVRMT 523

  Fly  1250 ATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVAS-VALAPISMD 1313
            |.||..:...:.|.::.:.....:|                         .||.| :....|:..
 Worm   524 AVTPITACRHAGPCNATAENCACRE-------------------------NGVCSYMCKCDINCS 563

  Fly  1314 EQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCG 1378
            :                |..|.|           ||.......|   |.|:       :.:..|.
 Worm   564 Q----------------RFPGCN-----------CAAGQCYTKA---CQCY-------RANWECN 591

  Fly  1379 AGCINRMLMIECGPLCSNGARCTN----KRFQQH-QCWPCRVFRTEKKGCGITAELLIPPG---E 1435
            ....|   |.:|..:.||..:|.|    :..|:. .|.|.::     .|.|:   .|:.|.   |
 Worm   592 PMTCN---MCKCDAIDSNIIKCRNFGMTRMIQKRTYCGPSKI-----AGNGL---FLLEPAEKDE 645

  Fly  1436 FIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINH-SCDPNAETQ 1499
            ||.||.||.|..:|.|||..:|  ||.:..|...:.....||:...||::|:.|| |.:|....:
 Worm   646 FITEYTGERISDDEAERRGAIY--DRYQCSYIFNIETGGAIDSYKIGNLARFANHDSKNPTCYAR 708

  Fly  1500 KWTVNGELRIGFFSVKPIQPGEEITFDYQY 1529
            ...|.||.||||::.:.::..||:||||.|
 Worm   709 TMVVAGEHRIGFYAKRRLEISEELTFDYSY 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	18/76 (24%)
		AWS	1358..1410	CDD:197795	11/56 (20%)
		SET_SETD2	1410..1551	CDD:380949	45/124 (36%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
mes-2	NP_496992.3	Septum_form	<210..266	CDD:433522	8/62 (13%)
		preSET_CXC	568..600	CDD:408079	10/55 (18%)
		SET_EZH	621..738	CDD:380917	44/126 (35%)