DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Set2 and met-1

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:NP_491340.2 Gene:met-1 / 172026 WormBaseID:WBGene00016603 Length:1604 Species:Caenorhabditis elegans


Alignment Length:1768 Identity:372/1768 - (21%)
Similarity:625/1768 - (35%) Gaps:560/1768 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   667 EKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQ 731
            :|..|.|:|. .||.||.:|.  .|.:|   |.::.|                           .
 Worm    10 KKRTEMVQTR-RKTAAAVQDG--GAVKE---NKAKPP---------------------------A 41

  Fly   732 KQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDS 796
            .|||....|....|..:|   ....:..|:.||..:.||.:...|.:..::.:...:..||:::.
 Worm    42 PQTPTKRAKRGRPPKIKT---DANTLNTPSTSSNLVDDKLLIESESQDSILTNEADSFLEKEVEE 103

  Fly   797 KKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPN--------TLDKKGKDTAQWSP 853
            .:..:.:.|.|   .....|.::|.|.....:...|.|....:        .|::|.......||
 Worm   104 IEDSSDILPDK---INSPEKPSVLVKRRSSTRLKVKTDEDEKDVPVNIEVAVLEEKSIQIEPTSP 165

  Fly   854 QLQTLPKSSTK--PPQESAPSVI--SKTTSNQPAP---------KEEQHAAKKGLSDNSPPSVLK 905
            .....|:.||.  |..|....::  ::.||:...|         |||:...||..||.|      
 Worm   166 AHPEDPQPSTSSLPLVEPIEDIVEPNEPTSSADPPVSNIKDEDIKEEEPLIKKPASDES------ 224

  Fly   906 AKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLS 970
                            ::||:||::...|..:.          ||.|:..|..::|:|.      
 Worm   225 ----------------ESMDIANSESGNDSDSS----------EADPRTIPSFSIPLPD------ 257

  Fly   971 GKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSS 1035
                       ...||..:......|..|.|:                            :.|..
 Worm   258 -----------TPPPNFAKRGEIHVDVDQKNS----------------------------KQSGE 283

  Fly  1036 SSTP---TREVAASSPVSTSSDSSSK--------RNGSKRTTSDLDGGSKLDQRRYTICEDRQPE 1089
            |.:|   .||.:||:|:|:.:.|..:        ::.:..:.|.|                 .|.
 Worm   284 SQSPWERAREKSASNPLSSPTMSRPRIHFLHPAYQSFTNDSVSPL-----------------PPP 331

  Fly  1090 TAIPVPLTKR-------RFSMHPKASAN-PLHDTLLQTAGKKR-------GRKEGKESLSRQNSL 1139
            ...|.|..::       .|.|..|.:|| |    :|:|:..::       .......|||..|| 
 Worm   332 PPEPAPAREKVENGGPTTFKMTFKKAANIP----ILKTSAFEQPSSPPPSSSVSSSISLSEVNS- 391

  Fly  1140 DSSSSASQGAPKKK------------------------------ALKSAEILSA-------ALLE 1167
             |:|.||:.:|.|:                              |::|||..||       .||.
 Worm   392 -STSIASESSPAKRSSNFDLTASNELPPPQMVELPKLSFFNMPPAVRSAEDDSAMTSEEPILLLR 455

  Fly  1168 TESSE---------STSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLL------------ 1211
            :.:|.         :|....||:..::|.             .|...:.||.:            
 Worm   456 SPNSATPDDDALFLTTPPPPKMTESEIQA-------------LKVATEKVNQVIARREDSEKDVR 507

  Fly  1212 -KRDKVDEDQRKEGQDEVKREADPE-EDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKE 1274
             :.|:.|.|:|::.:|...|:.|.| .|:..::..:.|..|.......|:.:..:........::
 Worm   508 HREDRDDYDRRRDDRDRRSRKTDSERNDQRGRQREDDERRAREREREVTKRHDREREEMRLQKQK 572

  Fly  1275 LETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQ 1339
            .|.........||:::....:..:...         .|:|:.      :.|.|:.::   :..|:
 Worm   573 DEERRKKDEEERIQKENDEKKQKEDEA---------KMEEEK------KKIKEEEMK---IPEFE 619

  Fly  1340 LLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKR 1404
            |:.|:.|.......::...:.|:|..||     |:.|... |:||.::.||...|.  .:|.|:|
 Worm   620 LISESKYLTRNANKKKTESLTCECHRTG-----GNCSDNT-CVNRAMLTECPSSCQ--VKCKNQR 676

  Fly  1405 FQQHQCWPCRVFRT-EKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFM 1468
            |.:.:......|.| ..||||:.|...|..|.||:||:|||::.:::|:|:..|:.|:...::::
 Worm   677 FAKKKYAAVEAFHTGTAKGCGLRAVKDIKKGRFIIEYIGEVVERDDYEKRKTKYAADKKHKHHYL 741

  Fly  1469 ALRGEAVIDATSKGNISRYINHSCDPNAETQKWTV---NGEL-RIGFFSVKPIQPGEEITFDYQY 1529
            ...|...||||..||.||::||||||||..:||:|   .|:: |:||||.:.|:.|||||||||:
 Worm   742 CDTGVYTIDATVYGNPSRFVNHSCDPNAICEKWSVPRTPGDVNRVGFFSKRFIKAGEEITFDYQF 806

  Fly  1530 LRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDSD------AEMDEEELEAEPEEGQPRK 1588
            :.||||||:|:|.:|:|.||||.:|     |:...:.|.|      ..|||||.|          
 Worm   807 VNYGRDAQQCFCGSASCSGWIGQKP-----EEFSSDEDDDIVTTRHINMDEEEEE---------- 856

  Fly  1589 SAKAKAKSKLKAKLPLATGRKRKEQTKPK-----DREYKAGRWLKPSATGSSSSAEKPPKKPKVN 1648
                    ||:. |......:|.|..|..     .|..|..|.:...|:..:..:::        
 Worm   857 --------KLEG-LDHLGNHERNEVIKDMLDDLVIRNKKHARKVITIASAMTDYSQR-------- 904

  Fly  1649 KFQAMLEDPDVVEELSLLRRGGLKNQQDTLRFSRCLVRAKLLKTRLALLRVLTHGELPCRRLFLD 1713
                    .||::|:                ||.        .|.:.:.:            |..
 Worm   905 --------VDVIQEI----------------FSS--------DTSVTVQK------------FYA 925

  Fly  1714 YHGLRLLHA-WISENGNDD------QLREALLDTLES----LPIPNRTMLSDSR---------VY 1758
            ..|:..|.| |:||   ||      :|.:|:|..|.:    ....|..:|.||.         .|
 Worm   926 KEGMATLMAEWLSE---DDYSLDNLKLVQAILKALHTELFDSCAKNDRLLRDSTSRWVNAKMDEY 987

  Fly  1759 QSVQLWSNSLEQQLAVVPQEKQ------AALHKRMV-----------ALLQKWQALPEIFRIPKR 1806
            ..:|:.::||   :|.|....|      ..:.|.:|           .|.|.|......|:|||:
 Worm   988 VDIQVIADSL---IACVEDPVQEYKDVCKVIEKGLVENFTRAKEMAYRLNQYWFNRSVSFKIPKK 1049

  Fly  1807 ERIEQMKE--------------HE---READRQQKHVHASTALEDQRERESSNDRFRQDRFRRDT 1854
            .|....|:              |:   |......:|..:|.:....:|||.|:.||..:  ..|.
 Worm  1050 IRDPVPKDVPVRQEDATTSSQSHDNSSRTVSPNHRHHSSSYSNSCYQEREPSHIRFFNN--GNDV 1112

  Fly  1855 TSSRIGKPIRMSGNNTICTITTQQKGSNGAPDGMTRNDNRRRS---DIGPPSEQRRTL----SKE 1912
            ...|.|   ...|||......:::...:...|....|..|.||   .:.|.:.:||.|    :..
 Worm  1113 HQYRFG---GYHGNNYNDNYFSRRPNKDSYRDRRRFNGRRSRSRSRSVSPQNYKRRKLDEHDNNH 1174

  Fly  1913 LRRSLFERKVALDEAERRVCTEDRLEHEL-RCEFFGADINTDPK--------------------- 1955
            .:||....:......|:...:.:..|... |.:..||.|.|..:                     
 Worm  1175 RQRSPIRDRHTSPGGEKTPSSNNSGERNYKRLDIRGARIKTIKEDLEAAAAAAAAAAVPSEVQAY 1239

  Fly  1956 ------------QLPFYQKTDTNEWFN---------SDDVPVPAPPRTELLTKALLSPDIDVGQ- 1998
                        |:|.|:.....:..|         :...|...|.:..:||...|.|:..:|: 
 Worm  1240 PHEHTAVHQSVYQMPGYESYGVYDPVNGVYMYPHPGAGYYPPAYPQQPIMLTMDTLPPNDRLGEL 1304

  Fly  1999 ------------------------------------------GATDVEYKLPPGVDPLPPAWNWQ 2021
                                                      .|.:.|.|....:......|...
 Worm  1305 YEKASIEQLAQRDAIVRQELELIRIQIERKTAQKEAIKAACRRANEEEAKRQEALAKTKYVWAIA 1369

  Fly  2022 VTSDGDIYYYNLRERISQWEPPSPEQRL------------QTLLEENTTQQPLHELQIDPAVLEN 2074
            .:..|:.||||...:.:||..|:|.|.|            ..:.:|.|.::...|:...|.|::.
 Worm  1370 KSEAGETYYYNKITKETQWTAPTPVQGLLEPACGASPDTTVVIADEITEEEQQAEVLEKPRVVKE 1434

  Fly  2075 ELIQVDTDYVGSLSAKSLAQYIEAKVRERRDLRRSKLVSIRLISPRRDEDRLYNQLESRKYKENK 2139
            |:|:..:.......:....:.:..||    ::.||.       ||:...||..::.:||  ::::
 Worm  1435 EVIEPGSQSETQKESPEKVRVVVPKV----EVERSP-------SPKSSRDREKDREKSR--EKDR 1486

  Fly  2140 EKIRRRKELYRRR 2152
            |:.|.|:|..:.|
 Worm  1487 ERDRDRREGSKHR 1499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 16/51 (31%)
SET 1414..1533 CDD:214614 56/123 (46%)
PostSET 1535..1551 CDD:214703 9/15 (60%)
WW 2014..2043 CDD:278809 8/28 (29%)
SRI 2270..2348 CDD:285448
met-1NP_491340.2 PHA03283 <219..308 CDD:223032 29/165 (18%)
AWS 637..682 CDD:197795 16/52 (31%)
SET 694..810 CDD:214614 54/115 (47%)
tolA_full <1300..>1375 CDD:274303 5/74 (7%)
WW 1366..1393 CDD:238122 9/26 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 109 1.000 Domainoid score I3988
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 237 1.000 Inparanoid score I2129
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002762
OrthoInspector 1 1.000 - - oto17258
orthoMCL 1 0.900 - - OOG6_102278
Panther 1 1.100 - - LDO PTHR22884
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.990

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