Protein Alignment Set2 and met-1

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_491340.2
• Gene: met-1 / 172026
• WormBaseID: WBGene00016603
• Length: 1604
• Species: Caenorhabditis elegans
• Alignment Length: 1768
• Identity: 372/1768 - (21%)
• Similarity: 625/1768 - (35%)
• Gaps: 560/1768 - (31%)

  Fly   667 EKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQ 731
            :|..|.|:|. .||.||.:|.  .|.:|   |.::.|                           .
 Worm    10 KKRTEMVQTR-RKTAAAVQDG--GAVKE---NKAKPP---------------------------A 41

  Fly   732 KQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDS 796
            .|||....|....|..:|   ....:..|:.||..:.||.:...|.:..::.:...:..||:::.
 Worm    42 PQTPTKRAKRGRPPKIKT---DANTLNTPSTSSNLVDDKLLIESESQDSILTNEADSFLEKEVEE 103

  Fly   797 KKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPN--------TLDKKGKDTAQWSP 853
            .:..:.:.|.|   .....|.::|.|.....:...|.|....:        .|::|.......||
 Worm   104 IEDSSDILPDK---INSPEKPSVLVKRRSSTRLKVKTDEDEKDVPVNIEVAVLEEKSIQIEPTSP 165

  Fly   854 QLQTLPKSSTK--PPQESAPSVI--SKTTSNQPAP---------KEEQHAAKKGLSDNSPPSVLK 905
            .....|:.||.  |..|....::  ::.||:...|         |||:...||..||.|
 Worm   166 AHPEDPQPSTSSLPLVEPIEDIVEPNEPTSSADPPVSNIKDEDIKEEEPLIKKPASDES------ 224

  Fly   906 AKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLS 970
                            ::||:||::...|..:.          ||.|:..|..::|:|.
 Worm   225 ----------------ESMDIANSESGNDSDSS----------EADPRTIPSFSIPLPD------ 257

  Fly   971 GKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSS 1035
                       ...||..:......|..|.|:                            :.|..
 Worm   258 -----------TPPPNFAKRGEIHVDVDQKNS----------------------------KQSGE 283

  Fly  1036 SSTP---TREVAASSPVSTSSDSSSK--------RNGSKRTTSDLDGGSKLDQRRYTICEDRQPE 1089
            |.:|   .||.:||:|:|:.:.|..:        ::.:..:.|.|                 .|.
 Worm   284 SQSPWERAREKSASNPLSSPTMSRPRIHFLHPAYQSFTNDSVSPL-----------------PPP 331

  Fly  1090 TAIPVPLTKR-------RFSMHPKASAN-PLHDTLLQTAGKKR-------GRKEGKESLSRQNSL 1139
            ...|.|..::       .|.|..|.:|| |    :|:|:..::       .......|||..||
 Worm   332 PPEPAPAREKVENGGPTTFKMTFKKAANIP----ILKTSAFEQPSSPPPSSSVSSSISLSEVNS- 391

  Fly  1140 DSSSSASQGAPKKK------------------------------ALKSAEILSA-------ALLE 1167
             |:|.||:.:|.|:                              |::|||..||       .||.
 Worm   392 -STSIASESSPAKRSSNFDLTASNELPPPQMVELPKLSFFNMPPAVRSAEDDSAMTSEEPILLLR 455

  Fly  1168 TESSE---------STSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLL------------ 1211
            :.:|.         :|....||:..::|.             .|...:.||.:
 Worm   456 SPNSATPDDDALFLTTPPPPKMTESEIQA-------------LKVATEKVNQVIARREDSEKDVR 507

  Fly  1212 -KRDKVDEDQRKEGQDEVKREADPE-EDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKE 1274
             :.|:.|.|:|::.:|...|:.|.| .|:..::..:.|..|.......|:.:..:........::
 Worm   508 HREDRDDYDRRRDDRDRRSRKTDSERNDQRGRQREDDERRAREREREVTKRHDREREEMRLQKQK 572

  Fly  1275 LETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQ 1339
            .|.........||:::....:..:...         .|:|:.      :.|.|:.::   :..|:
 Worm   573 DEERRKKDEEERIQKENDEKKQKEDEA---------KMEEEK------KKIKEEEMK---IPEFE 619

  Fly  1340 LLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKR 1404
            |:.|:.|.......::...:.|:|..||     |:.|... |:||.::.||...|.  .:|.|:|
 Worm   620 LISESKYLTRNANKKKTESLTCECHRTG-----GNCSDNT-CVNRAMLTECPSSCQ--VKCKNQR 676

  Fly  1405 FQQHQCWPCRVFRT-EKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFM 1468
            |.:.:......|.| ..||||:.|...|..|.||:||:|||::.:::|:|:..|:.|:...::::
 Worm   677 FAKKKYAAVEAFHTGTAKGCGLRAVKDIKKGRFIIEYIGEVVERDDYEKRKTKYAADKKHKHHYL 741

  Fly  1469 ALRGEAVIDATSKGNISRYINHSCDPNAETQKWTV---NGEL-RIGFFSVKPIQPGEEITFDYQY 1529
            ...|...||||..||.||::||||||||..:||:|   .|:: |:||||.:.|:.|||||||||:
 Worm   742 CDTGVYTIDATVYGNPSRFVNHSCDPNAICEKWSVPRTPGDVNRVGFFSKRFIKAGEEITFDYQF 806

  Fly  1530 LRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDSD------AEMDEEELEAEPEEGQPRK 1588
            :.||||||:|:|.:|:|.||||.:|     |:...:.|.|      ..|||||.|
 Worm   807 VNYGRDAQQCFCGSASCSGWIGQKP-----EEFSSDEDDDIVTTRHINMDEEEEE---------- 856

  Fly  1589 SAKAKAKSKLKAKLPLATGRKRKEQTKPK-----DREYKAGRWLKPSATGSSSSAEKPPKKPKVN 1648
                    ||:. |......:|.|..|..     .|..|..|.:...|:..:..:::
 Worm   857 --------KLEG-LDHLGNHERNEVIKDMLDDLVIRNKKHARKVITIASAMTDYSQR-------- 904

  Fly  1649 KFQAMLEDPDVVEELSLLRRGGLKNQQDTLRFSRCLVRAKLLKTRLALLRVLTHGELPCRRLFLD 1713
                    .||::|:                ||.        .|.:.:.:            |..
 Worm   905 --------VDVIQEI----------------FSS--------DTSVTVQK------------FYA 925

  Fly  1714 YHGLRLLHA-WISENGNDD------QLREALLDTLES----LPIPNRTMLSDSR---------VY 1758
            ..|:..|.| |:||   ||      :|.:|:|..|.:    ....|..:|.||.         .|
 Worm   926 KEGMATLMAEWLSE---DDYSLDNLKLVQAILKALHTELFDSCAKNDRLLRDSTSRWVNAKMDEY 987

  Fly  1759 QSVQLWSNSLEQQLAVVPQEKQ------AALHKRMV-----------ALLQKWQALPEIFRIPKR 1806
            ..:|:.::||   :|.|....|      ..:.|.:|           .|.|.|......|:|||:
 Worm   988 VDIQVIADSL---IACVEDPVQEYKDVCKVIEKGLVENFTRAKEMAYRLNQYWFNRSVSFKIPKK 1049

  Fly  1807 ERIEQMKE--------------HE---READRQQKHVHASTALEDQRERESSNDRFRQDRFRRDT 1854
            .|....|:              |:   |......:|..:|.:....:|||.|:.||..:  ..|.
 Worm  1050 IRDPVPKDVPVRQEDATTSSQSHDNSSRTVSPNHRHHSSSYSNSCYQEREPSHIRFFNN--GNDV 1112

  Fly  1855 TSSRIGKPIRMSGNNTICTITTQQKGSNGAPDGMTRNDNRRRS---DIGPPSEQRRTL----SKE 1912
            ...|.|   ...|||......:::...:...|....|..|.||   .:.|.:.:||.|    :..
 Worm  1113 HQYRFG---GYHGNNYNDNYFSRRPNKDSYRDRRRFNGRRSRSRSRSVSPQNYKRRKLDEHDNNH 1174

  Fly  1913 LRRSLFERKVALDEAERRVCTEDRLEHEL-RCEFFGADINTDPK--------------------- 1955
            .:||....:......|:...:.:..|... |.:..||.|.|..:
 Worm  1175 RQRSPIRDRHTSPGGEKTPSSNNSGERNYKRLDIRGARIKTIKEDLEAAAAAAAAAAVPSEVQAY 1239

  Fly  1956 ------------QLPFYQKTDTNEWFN---------SDDVPVPAPPRTELLTKALLSPDIDVGQ- 1998
                        |:|.|:.....:..|         :...|...|.:..:||...|.|:..:|:
 Worm  1240 PHEHTAVHQSVYQMPGYESYGVYDPVNGVYMYPHPGAGYYPPAYPQQPIMLTMDTLPPNDRLGEL 1304

  Fly  1999 ------------------------------------------GATDVEYKLPPGVDPLPPAWNWQ 2021
                                                      .|.:.|.|....:......|...
 Worm  1305 YEKASIEQLAQRDAIVRQELELIRIQIERKTAQKEAIKAACRRANEEEAKRQEALAKTKYVWAIA 1369

  Fly  2022 VTSDGDIYYYNLRERISQWEPPSPEQRL------------QTLLEENTTQQPLHELQIDPAVLEN 2074
            .:..|:.||||...:.:||..|:|.|.|            ..:.:|.|.::...|:...|.|::.
 Worm  1370 KSEAGETYYYNKITKETQWTAPTPVQGLLEPACGASPDTTVVIADEITEEEQQAEVLEKPRVVKE 1434

  Fly  2075 ELIQVDTDYVGSLSAKSLAQYIEAKVRERRDLRRSKLVSIRLISPRRDEDRLYNQLESRKYKENK 2139
            |:|:..:.......:....:.:..||    ::.||.       ||:...||..::.:||  ::::
 Worm  1435 EVIEPGSQSETQKESPEKVRVVVPKV----EVERSP-------SPKSSRDREKDREKSR--EKDR 1486

  Fly  2140 EKIRRRKELYRRR 2152
            |:.|.|:|..:.|
 Worm  1487 ERDRDRREGSKHR 1499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	19/122 (16%)
		AWS	1358..1410	CDD:197795	16/51 (31%)
		SET_SETD2	1410..1551	CDD:380949	68/145 (47%)
		WW	2014..2043	CDD:459800	8/28 (29%)
		SRI	2266..2355	CDD:462404
met-1	NP_491340.2	PRK12323	<23..263	CDD:481241	60/326 (18%)
		AWS	637..682	CDD:197795	16/52 (31%)
		SET	682..828	CDD:394802	68/145 (47%)
		WW	1366..1393	CDD:238122	9/26 (35%)