DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and Ezh2

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_006505583.1	Gene:	Ezh2 / 14056	MGIID:	107940	Length:	751	Species:	Mus musculus

Alignment Length:	729	Identity:	157/729 - (21%)
Similarity:	248/729 - (34%)	Gaps:	254/729 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   880 NQPAPKEEQHAAKKGLSDN------SPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNK 938
            :.|..:||:   :|.|.||      .||....|           |.:|:|:..........|:.|
Mouse   191 DDPDEREEK---QKDLEDNRDDKETCPPRKFPA-----------DKIFEAISSMFPDKGTAEELK 241

  Fly   939 KKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTS 1003
            :|.|:: |:.:.|..:.|                         |.:||::   .|::.|.|...|
Mouse   242 EKYKEL-TEQQLPGALPP-------------------------ECTPNID---GPNAKSVQREQS 277

  Fly  1004 AGKLKPSKVKKKINPRRSTICEAAKDLR-------SSSSSSTPTREVAASSPVSTSSDSSSKRNG 1061
                        ::...:..|.......       |.|..:||               ::.||
Mouse   278 ------------LHSFHTLFCRRCFKYDCFLHRKCSYSFHATP---------------NTYKR-- 313

  Fly  1062 SKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGR 1126
             |.|.:.|| ......:.|...|..:...|   .||..|....||           :..|::|||
Mouse   314 -KNTETALD-NKPCGPQCYQHLEGAKEFAA---ALTAERIKTPPK-----------RPGGRRRGR 362

  Fly  1127 KEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPEL 1191
                  |...:|..|:.:.|                  :||::.::|                :.
Mouse   363 ------LPNNSSRPSTPTIS------------------VLESKDTDS----------------DR 387

  Fly  1192 EAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVANMETPATTPTPS 1256
            ||....|        |.|   .||  |::.|:.:.....||:.......:...|:|.|
Mouse   388 EAGTETG--------GEN---NDK--EEEEKKDETSSSSEANSRCQTPIKMKPNIEPP------- 432

  Fly  1257 PTQSNPEDSASTTTVLKEL-----ETGGGVRR-----------SHRIKQKPQGPRASQGRGVASV 1305
               .|.|.|.:..::.:.|     :....:.|           ..|:|:              |.
Mouse   433 ---ENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKE--------------SS 480

  Fly  1306 ALAPISMDEQLAELANIEAINEQFLRSEGL-----NTFQLLKE-------NFYRC--ARQ----- 1351
            .:||:..::       ::....:..|...|     ...||.|:       |:..|  .||
Mouse   481 IIAPVPTED-------VDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSS 538

  Fly  1352 ----VSQENAEMQCDCFLTGDEEAQGHL---SCGAGCINR-----MLMIECGP-LCSNGARCTNK 1403
                ::|...|..|.|    ..|.|...   .|.|.|..:     :.:.||.| ||.......:.
Mouse   539 CPCVIAQNFCEKFCQC----SSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHW 599

  Fly  1404 RFQQHQCWPCRVFRTEKK----------GCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYS 1458
            ..:...|..|.:.|..||          |.||..:..:...|||.||.||:|..:|.:||..:|
Mouse   600 DSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVY- 663

  Fly  1459 KDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEI 1523
             |:....:...|..:.|:|||.|||..|:.|||.:||...:...|||:.|||.|:.:.||.|||:
Mouse   664 -DKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEEL 727

  Fly  1524 TFDYQY-----LRY 1532
            .|||:|     |:|
Mouse   728 FFDYRYSQADALKY 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	13/60 (22%)
		SET	1414..1533	CDD:214614	51/134 (38%)
		PostSET	1535..1551	CDD:214703
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Ezh2	XP_006505583.1	EZH2_WD-Binding	39..68	CDD:402972
		PRC2_HTH_1	158..249	CDD:407952	17/72 (24%)
		preSET_CXC	564..595	CDD:408079	8/30 (27%)
		SET_EZH2	614..733	CDD:380995	47/120 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848385
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840