Protein Alignment Set2 and Ezh1

DIOPT Version :9

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_031996.1
• Gene: Ezh1 / 14055
• MGIID: 1097695
• Length: 750
• Species: Mus musculus
• Alignment Length: 620
• Identity: 141/620 - (22%)
• Similarity: 214/620 - (34%)
• Gaps: 219/620 - (35%)

  Fly  1084 EDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQ---NSLDSSSSA 1145
            :.:|.::...:|:|::|                      ||...||.:..|::   |.:..|:.|
Mouse   202 DGKQDDSKEDLPVTRKR----------------------KRHAIEGNKKSSKKQFPNDMIFSAIA 244

  Fly  1146 S----QGAPKKKALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIED 1206
            |    .|.|.....:..|:       ||.|:..:       ...|.:|.::..|     ||.::.
Mouse   245 SMFPENGVPDDMKERYREL-------TEMSDPNA-------LPPQCTPNIDGPN-----AKSVQR 290

  Fly  1207 GVNL-----------LKRD------KVDEDQRKEGQDEVKREADP-EED-----EFAQRVANMET 1248
            ..:|           .|.|      ....:..|....|:|.|.:| ..|     |.|:..|.:..
Mouse   291 EQSLHSFHTLFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHN 355

  Fly  1249 PATT---------PTPSPTQSNPEDSASTTTVLKE----LETG----GGVRRSHRIKQKPQGPRA 1296
            |.:.         |..|.:.||...||...|  ||    .:||    .....::...|.|...:|
Mouse   356 PRSKCSGRRRRRHPVVSASCSNASASAMAET--KEGDSDRDTGNDWASSSSEANSRCQTPTKQKA 418

  Fly  1297 SQGRGVASVALAPISMDE---------------------QLAELANIEAINE--QFLRSEG---- 1334
            |.......|..||....|                     .:|.|...:...:  ||...|.
Mouse   419 SPAPAQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK 483

  Fly  1335 LNTFQLL-----KENFYR-----CAR-QVSQENAEMQ-----------------CDCFLTGDEEA 1371
            |.|.:|:     |:..:|     |.: |:.::|...|                 |.|.:|.:
Mouse   484 LPTDELMNPAQKKKRKHRLWAAHCRKIQLKKDNNSTQVYNYQPCDHPDRPCDSTCPCIMTQN--- 545

  Fly  1372 QGHLSCGAGCINRMLMIECGPLCSN---GARC-TNKRFQQHQC--------------------WP 1412
                .|...|       :|.|.|.|   |.|| |....:|..|                    |.
Mouse   546 ----FCEKFC-------QCSPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWD 599

  Fly  1413 CRVFRTEKKGC----GITAELLIPP----------------GEFIMEYVGEVIDSEEFERRQHLY 1457
            |:|  ...|.|    |:...||:.|                .|||.||.||:|..:|.:||..:|
Mouse   600 CKV--VSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVY 662

  Fly  1458 SKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEE 1522
              |:....:...|..:.|:|||.|||..|:.|||.:||...:...|||:.|||.|:.:.||.|||
Mouse   663 --DKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEE 725

  Fly  1523 ITFDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSD 1557
            :.|||:|            ..|:...::|.|.::|
Mouse   726 LFFDYRY------------SQADALKYVGIERETD 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	15/72 (21%)
		SET	1414..1533	CDD:214614	50/138 (36%)
		PostSET	1535..1551	CDD:214703	1/15 (7%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Ezh1	NP_031996.1	EZH2_WD-Binding	42..70	CDD:288468
		SANT	436..477	CDD:238096	5/40 (13%)
		SANT	436..477	CDD:197842	5/40 (13%)
		SET	<466..730	CDD:225491	76/281 (27%)
		SET	616..737	CDD:214614	47/134 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848412
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840