DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and DIDO1

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_011526806.1	Gene:	DIDO1 / 11083	HGNCID:	2680	Length:	2276	Species:	Homo sapiens

Alignment Length:	1557	Identity:	313/1557 - (20%)
Similarity:	500/1557 - (32%)	Gaps:	500/1557 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SGPPSNPSPVASRGRGRGRPPKVALSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSECRRSS 68
            ||....|.|   :.:.:.:|.|.:|...|     ....:|.:.....| |||.::        ::
Human   467 SGKEQKPKP---KEKMKMKPEKPSLPKCG-----AQAGIKISSVHKRP-APEKKE--------TT 514

  Fly    69 RKKIIKFDVR-DLLNKNRKAHKIQIEARIDSN-PS--TGHSQSG-----TTAASTSM---ST--- 118
            .||.:....| :.|.|         ||..:|: ||  :.|:.:.     |.|.|.|:   ||
Human   515 VKKAVVVPARSEALGK---------EAACESSTPSWASDHNYNAVKPEKTAAPSPSLLYKSTKED 570

  Fly   119 ------ATASAASASSAATVSRL------------FSMFEMSHQSLPPPPPPPTALEIFAKPRPT 165
                  |.|.|||..:|...|.:            .|.|.....:.|....||:..:.....||.
Human   571 RRSEEKAAAMAASKKTAPPGSAVGKQPAPRNLVPKKSSFANVAAATPAIKKPPSGFKGTIPKRPW 635

  Fly   166 QSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAA---IIPTVIVPSCSDSDT 227
            .|   |..:|..||...|.|....|     |...:..|..:.|..|.   ::|:|.:.|.:....
Human   636 LS---ATPSSGASAARQAGPAPAAA-----TAASKKFPGSAALVGAVRKPVVPSVPMASPAPGRL 692

  Fly   228 NSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKR-LK--LGGRLESSDSGNSPSSSSPEVEPPA 289
            .:.|...|               :|.|::|.:::| ||  |..|:..||   ....:..||...|
Human   693 GAMSAAPS---------------QPNSQIRQNIRRSLKEILWKRVNDSD---DLIMTENEVGKIA 739

  Fly   290 LQDENAMDERPKQEQNLSRMVDAEENSDSDSQIIFIEIETESPKGE--------EEQEEGRPVEV 346
            |..|       |:..||.::.|....|...|    |....:.||.:        ||....:.|.:
Human   740 LHIE-------KEMFNLFQVTDNRYKSKYRS----IMFNLKDPKNQGLFHRVLREEISLAKLVRL 793

  Fly   347 EPQDLIDIDMELAKQEPTPDPEED-------------LDEIMVEVLSGPPSLWSADDEAEEEEDA 398
            :|::|:..::...|:.|.....|.             ..|.:.::...||    ..|..|::|.|
Human   794 KPEELVSKELSTWKERPARSVMESRTKLHNESKKTAPRQEAIPDLEDSPP----VSDSEEQQESA 854

  Fly   399 TVQRATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKT-LEETFAEIAAESSKQILEAEESQDQ 462
               ||.|        ..|:||.....|:.|..::.|.:. |.:...:|.   :.|:..||:....
Human   855 ---RAVP--------EKSTAPLLDVFSSMLKDTTSQHRAHLFDLNCKIC---TGQVPSAEDEPAP 905

  Fly   463 EEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSES 527
            ::|.:...:.::.|.....:|:..|.                .|.|||::..    .:.:|.||.
Human   906 KKQKLSASVKKEDLKSKHDSSAPDPA----------------PDSADEVMPE----AVPEVASEP 950

  Fly   528 DNIAAS---LNKDIF---------EPK-----VETKATCGE-VVPRPEMVTEDVYITEGIAATLE 574
            ...:||   :::..|         ||.     ....|:||. ||....:...|.......:.|..
Human   951 GLESASHPNVDRTYFPGPPGDGHPEPSPLEDLSPCPASCGSGVVTTVTVSGRDPRTAPSSSCTAV 1015

  Fly   575 KSAVVTKPTTEMIAETKLSDEVVIEPPLKDESDPKQTEVELPES---KPA-------VNIPKSER 629
            .||.....:|.|: |.:           :|...|..|.|.:|:|   ||:       :::|.|..
Human  1016 ASAASRPDSTHMV-EAR-----------QDVPKPVLTSVMVPKSILAKPSSSPDPRYLSVPPSPN 1068

  Fly   630 ILSAEVETTSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETT------------------ 676
            |      :||....|||..|       .|..:.|||..|...|:::.
Human  1069 I------STSESRSPPEGDT-------TLFLSRLSTIWKGFINMQSVAKFVTKAYPVSGCFDYLS 1120

  Fly   677 -----------------------PLKTEAAKE----DSPPAAPEEEASNSSEEPNFLLEDYESNQ 714
                                   .||:..:||    ...||..|||.:..|      |..|.|::
Human  1121 EDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYIS------LYSYFSSR 1179

  Fly   715 EQVAEDEMMKCNNQKGQK---------QTPLPEMKEPEKPVAETVSKKEKAMENPARSSP----- 765
            .:..    :..||.:..|         |.|:|....|              .|.|...||
Human  1180 GRFG----VVANNNRHVKDLYLIPLSAQDPVPSKLLP--------------FEGPGLESPRPNII 1226

  Fly   766 --AIVDKKVR----AGEMEKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKET 824
              .::.:|::    :||::              |||.|:     |..:.:|:...|
Human  1227 LGLVICQKIKRPANSGELD--------------KMDEKR-----TRLQPEEADVPA--------- 1263

  Fly   825 EKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKP---PQESAPSVISKTT--SNQPAP 884
                                       .|::.|:|:|..||   |..||.:.:|.|.  |..|.|
Human  1264 ---------------------------YPKVATVPQSEKKPSKYPLCSADAAVSTTPPGSPPPPP 1301

  Fly   885 KEEQHAAKKGLSDNSP--PSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTK 947
            ...:....|.||...|  ||...|...|.:          |...|::......|....|:.:...
Human  1302 PLPEPPVLKVLSSLKPAAPSPATAATTAAA----------ASTAASSTASSASKTASPLEHILQT 1356

  Fly   948 VEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYED--------SPNLERNSSPSSDSAQANTSA 1004
            :....|...|:|...||....|..:.    .|..||        .|.:::....|.|.|......
Human  1357 LFGKKKSFDPSAREPPGSTAGLPQEP----KTTAEDGVPAPPLLDPIVQQFGQFSKDKALEEEED 1417

  Fly  1005 GKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDL 1069
            .  :|...:::.:|.|:...:..:..|.......|....|....|:...:..:....:|.|..||
Human  1418 D--RPYDPEEEYDPERAFDTQLVERGRRHEVERAPEAAAAEREEVAYDPEDETILEEAKVTVDDL 1480

  Fly  1070 DGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLS 1134
            ......|.||.::....:|......|....:..|        |.:...|...:||..:|.:|:|.
Human  1481 PNRMCADVRRNSVERPAEPVAGAATPSLVEQQKM--------LEELNKQIEEQKRQLEEQEEALR 1537

  Fly  1135 RQNSL-------DSSSSASQGAPKKKALKSAEIL--------------------------SAALL 1166
            :|.:.       .|.|.|....|.|.:|..||:.                          .|..|
Human  1538 QQRAAVGVSMAHFSVSDALMSPPPKSSLPKAELFQQEQQSADKPASLPPASQASNHRDPRQARRL 1602

  Fly  1167 ETESSESTSSGSKMSRWDVQTS----PELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKE---- 1223
            .||:.|  ..|..:||...:.:    ||.:|:..            .|:.:..:...:.||
Human  1603 ATETGE--GEGEPLSRLSARGAQGALPERDASRG------------GLVGQAPMPVPEEKEPASS 1653

  Fly  1224 ----GQDEVKREADPEEDEFAQRVANMETPATT-------------PTPS--------PTQSNPE 1263
                |:   |..|..|:|.:.........|||.             |||.        |.|.:.|
Human  1654 PWASGE---KPPAGSEQDGWKAEPGEGTRPATVGDSSARPARRVLLPTPPCGALQPGFPLQHDGE 1715

  Fly  1264 DS-------ASTTTVL--------KELETGGGVRRSHRIKQKPQGPRASQGR-GVASVALAP 1309
            ..       ||....|        :.|.:.|   ||.....:.:|.|..|.| |..:..|.|
Human  1716 RDPFTCPGFASQDKALGSAQYEDPRNLHSAG---RSSSPAGETEGDREPQARPGEGTAPLPP 1774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795
		SET	1414..1533	CDD:214614
		PostSET	1535..1551	CDD:214703
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
DIDO1	XP_011526806.1	TNG2	<160..302	CDD:227367
		PHD_DIDO1_like	266..319	CDD:277109
		TFS2M	708..809	CDD:128786	27/114 (24%)
		SPOC	1093..1199	CDD:285043	18/115 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030