Protein Alignment Set2 and Ehmt2

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: NP_001390796.1
• Gene: Ehmt2 / 110147
• MGIID: 2148922
• Length: 1394
• Species: Mus musculus
• Alignment Length: 1235
• Identity: 245/1235 - (19%)
• Similarity: 418/1235 - (33%)
• Gaps: 367/1235 - (29%)

  Fly   587 IAETKLSDEVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLE 651
            :.:|..|:|.:      .:::|...|...|.|..:|.:...:.  .|:....::.|:..|..:||
Mouse   219 LGDTPQSEETL------PKANPDSLEPAGPSSPASVTVTVGDE--GADTPVGAASLIGDEPESLE 275

  Fly   652 SVSGPVLLETSLSTEEKSNENVETTPLK-----TEAAKEDSPPAAPE-----------EEASNSS 700
            ...|.::|..:..:...|.......|.:     |.|.|  |||:...           :.|:.:.
Mouse   276 GDGGRIVLGHATKSFPSSPSKGGACPSRAKMSMTGAGK--SPPSVQSLAMRLLSMPGAQGAATAG 338

  Fly   701 EEPNFLLEDYESNQEQV--AEDEMMKCNNQKGQKQTPLPEMKEPE------------KPVAETVS 751
            .||:......:..|.:|  |...|.|.:|    .|.|:||.:.||            ..|...|:
Mouse   339 PEPSPATTAAQEGQPKVHRARKTMSKPSN----GQPPIPEKRPPEVQHFRMSDDMHLGKVTSDVA 399

  Fly   752 KKEKA--------MENPARSSPAIVDK-KVRAGEMEKKVVKSTKG------TVPEK-KMDSKKSC 800
            |:.|.        :.:...|...|::| :.|..|..:.||.....      :|.|: ..|||...
Mouse   400 KRRKLNSGSLSEDLGSAGGSGDIILEKGEPRPLEEWETVVGDDFSLYYDAYSVDERVDSDSKSEV 464

  Fly   801 AAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKG-----KDTAQW---SPQLQ- 856
            .|:.....:|..:..:|...::|.|:|:...:.|..|.|..|:.|     |...:|   ||.::
Mouse   465 EALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKP 529

  Fly   857 TLPKSSTKPPQESAPSVISKTTSNQPA------------PKE----EQHAAKKGLSDNS------ 899
            :..:...:||:...|..::...|:.|:            |.|    ..||   |:|:::
Mouse   530 SRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHA---GVSNDTSSLETE 591

  Fly   900 --------------PPSVLKAKEKA---------VSG-FVECDAMFKAMDLANAQLR-----LDE 935
                          .|.:.:..|:|         |.| .:.|:|.....:......|     |.|
Mouse   592 RGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELLGCNAAILKRETMRPSSRVALMVLCE 656

  Fly   936 KNKKKLKK------------VPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVY-----ED 983
            .::.::.|            ..|.:|.    .|...|.....|..:|....:    |:     ||
Mouse   657 AHRARMVKHHCCPGCGYFCTAGTFLEC----HPDFRVAHRFHKACVSQLNGM----VFCPHCGED 713

  Fly   984 SPNLERNSSPSSD--SAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAAS 1046
            :...:..:.|..|  :....|:|..|.|.....   |.|:...:.:..:|.......|..:..|.
Mouse   714 ASEAQEVTIPRGDGGTPPIGTAAPALPPLAHDA---PGRADTSQPSARMRGHGEPRRPPCDPLAD 775

  Fly  1047 SPVSTSSDSSSKRNGSKRTTSDLDGGSKLD--QRRYTICEDRQPETAIPVPLTKRRFSMHPKASA 1109
            : :.:|..|.:..||...:...|..|...:  ::...|.|...|.:..|.|..:::...||:
Mouse   776 T-IDSSGPSLTLPNGGCLSAVGLPPGPGREALEKALVIQESESPPSPPPSPDRRKKLRFHPR--- 836

  Fly  1110 NPLHDTLLQTAGKKRGRKEGKESLSRQNSLD---SSSSASQGAPKKKALK--SAEILSAALLETE 1169
             .|:.::      |:|..: |..|...::||   .|...|:..|...|.:  |.||....|
Mouse   837 -QLYLSV------KQGELQ-KVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLL---- 889

  Fly  1170 SSESTSSGSKMSRWD-VQTSPELEA-ANPFGDIAKFI-----------EDGVNLLKRDKVDEDQR 1221
                 .:|:.::..| .|.:|.:|| .|...::|:::           |||...|
Mouse   890 -----QAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQLGGCVYSKEEDGSTCL---------- 939

  Fly  1222 KEGQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELE---------- 1276
                            ..|.::.|:|..:...:......|.:||...|.::...|
Mouse   940 ----------------HHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIDVIRML 988

  Fly  1277 -----------------------TGG---------------------------GVRRSHR----- 1286
                                   ||.                           ..|.|:.
Mouse   989 LTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAQCDLHAVNYHGDTPLHIAARESYHDCVLL 1053

  Fly  1287 IKQKPQGPRASQGRGVASVALAPISMDEQLAELANIE---AINEQFLRSEGL------------- 1335
            ...:...|......|..:..|.|...|...|...|.:   .:..:.:|:|.:
Mouse  1054 FLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAVRTEKIICRDVARGYENVP 1118

  Fly  1336 -------------NTFQLLKENFYRCARQVSQENAEMQ-CDCFLTGDEEAQGHLSCGAGCI---- 1382
                         ..::.:.||.......:.:....:| |.|.   |:.:..:..||...|
Mouse  1119 IPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCV---DDCSSSNCLCGQLSIRCWY 1180

  Fly  1383 ----------NRM---LMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPG 1434
                      |::   |:.||...||....|.|:..|.......:::||.|.|.|:.|...||.|
Mouse  1181 DKDGRLLQEFNKIEPPLIFECNQACSCWRSCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQG 1245

  Fly  1435 EFIMEYVGEVIDSEEFERRQ---HLYSKDRNRHYYFMALRGEA-VIDATSKGNISRYINHSCDPN 1495
            .||.|||||:|...|.:.|:   :|:..|..        .||. .|||...|||||:|||.||||
Mouse  1246 TFICEYVGELISDAEADVREDDSYLFDLDNK--------DGEVYCIDARYYGNISRFINHLCDPN 1302

  Fly  1496 -AETQKWTVNGEL---RIGFFSVKPIQPGEEITFDY---------QYLRYGRDAQRCYCEAANCR 1547
             ...:.:.::.:|   ||.|||.:.|:.|||:.|||         :|.       .|.|.:..|:
Mouse  1303 IIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYF-------TCQCGSEKCK 1360

  Fly  1548  1547
            Mouse  1361  1360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	34/152 (22%)
		AWS	1358..1410	CDD:197795	16/69 (23%)
		SET_SETD2	1410..1551	CDD:380949	55/155 (35%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
Ehmt2	NP_001390796.1	PHA03247	<126..379	CDD:223021	36/173 (21%)
		EHMT_ZBD	594..723	CDD:411018	20/136 (15%)
		ANKYR	838..1071	CDD:440430	41/274 (15%)
		ANK repeat	870..899	CDD:293786	7/37 (19%)
		ANK repeat	934..966	CDD:293786	7/57 (12%)
		ANK repeat	969..999	CDD:293786	2/29 (7%)
		ANK repeat	1001..1032	CDD:293786	2/30 (7%)
		ANK repeat	1034..1065	CDD:293786	3/30 (10%)
		SET_EHMT2	1132..1370	CDD:380931	73/247 (30%)