DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and EHMT2

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_006715037.1	Gene:	EHMT2 / 10919	HGNCID:	14129	Length:	1274	Species:	Homo sapiens

Alignment Length:	1377	Identity:	272/1377 - (19%)
Similarity:	439/1377 - (31%)	Gaps:	496/1377 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   541 PKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDE 605
            |::.|..|.   .|.|.:.::.....|..|..|||.   |:..||.: ...|.|     .|..:|
Human    54 PQLSTGLTS---PPVPCLPSQGEAPAEMGALLLEKE---TRGATERV-HGSLGD-----TPRSEE 106

  Fly   606 SDPKQTEVEL----PESKPAVNIPKSERILSAEVETTSSPLVPPECCTLES----VSGPVLL--- 659
            :.||.|...|    |.|..:|.:...:.  .|:....::||:..|...||.    ..|.:||
Human   107 TLPKATPDSLEPAGPSSPASVTVTVGDE--GADTPVGATPLIGDESENLEGDGDLRGGRILLGHA 169

  Fly   660 ------------------ETSLSTEEKSNENVETTPLK---------TEAAKEDSPPAAPEEEAS 697
                              :.|::...||..:|::..::         ..||..:.|||....|.
Human   170 TKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEG- 233

  Fly   698 NSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPE-------------KPVAET 749
                              |.......|..::.|..|.|:||.:.||             ..|...
Human   234 ------------------QPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSD 280

  Fly   750 VSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKG-----------------------TVPE 791
            ::|:.|.......|..  :....|:||     |..|||                       :|.|
Human   281 LAKRRKLNSGGGLSEE--LGSARRSGE-----VTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDE 338

  Fly   792 K-KMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKG-----KDTAQ 850
            : ..|||....|:|....:|..:..:|. .::|.|:|:...:.|..|.|..|:.|     |...:
Human   339 RVDSDSKSEVEALTEQLSEEEEEEEEEE-EEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKK 402

  Fly   851 W---SPQLQ-TLPKSSTKPPQESAPSVISKTTSNQPA------------PKE----EQHAAKKGL 895
            |   ||.:: :..:...:||:...|..::...|:.|:            |.|    ..||   |:
Human   403 WRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHA---GV 464

  Fly   896 SDNSPPSVLKAKEKAVSGFVE---CDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPP 957
            |:::  |.|:.:.    ||.|   |....:|..:.    |:.|:...|.....:
Human   465 SNDT--SSLETER----GFEELPLCSCRMEAPKID----RISERAGHKCMATES----------- 508

  Fly   958 TAVPVPGQKKSLSGKTS--LRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINP-- 1018
                |.|:   |||..:  |:|.|:        |.||..:......|...::    ||....|
Human   509 ----VDGE---LSGCNAAILKRETM--------RPSSRVALMVLCETHRARM----VKHHCCPGC 554

  Fly  1019 ----RRSTICEAAKDLRSS----------------------------------SSSSTPTREVAA 1045
                ...|..|...|.|.:                                  ....||....||
Human   555 GYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAA 619

  Fly  1046 SSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASAN 1110
            .:|...|.|...:.:.|:.:......|           |.|:|                   ..:
Human   620 PAPPPLSQDVPGRADTSQPSARMRGHG-----------EPRRP-------------------PCD 654

  Fly  1111 PLHDTL--------------LQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKK-------- 1153
            ||.||:              |...|...|  .|:|:|.:...:..|..      :||
Human   655 PLADTIDSSGPSLTLPNGGCLSAVGLPLG--PGREALEKALVIQESER------RKKLRFHPRQL 711

  Fly  1154 --ALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDIA---KFIEDGVNLLKR 1213
              ::|..|:....|:..::.:......:.|:    .:| |.||...|.:.   ..::.|.|:
Human   712 YLSVKQGELQKVILMLLDNLDPNFQSDQQSK----RTP-LHAAAQKGSVEICHVLLQAGANI--- 768

  Fly  1214 DKVDEDQRKEGQD-------EVKREA--------DPEED-----EFAQRVANMETPATTPTPSPT 1258
            :.||:.||....:       ||.|..        ..|||     ..|.::.|:|..:...:....
Human   769 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQV 833

  Fly  1259 QSNPEDSASTTTVL-----KELET-------GGGVRRSHRIKQKPQGPRASQGRGV--------A 1303
            ..|.:||...|.::     |.:|.       |..|..:..:.:     |..:...:        .
Human   834 DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSE-----RLVEEENICLHWASFTG 893

  Fly  1304 SVALAPISMDEQL----------------------------------AELANIE----------- 1323
            |.|:|.:.::.:.                                  .||.|.|
Human   894 SAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPER 958

  Fly  1324 ---------------AINEQFLRSEGL--------------------------NTFQLLKENFYR 1347
                           .:..:.:|:|.:                          ..::.:.||...
Human   959 SDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCET 1023

  Fly  1348 CARQVSQENAEMQ-CDCFLTGDEEAQGHLSCGAGCI--------------NRM---LMIECGPLC 1394
            ....:.:....:| |.|.   |:.:..:..||...|              |::   |:.||...|
Human  1024 STMNIDRNITHLQHCTCV---DDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQAC 1085

  Fly  1395 SNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQ---HL 1456
            |....|.|:..|.......:::||.|.|.|:.|...||.|.||.|||||:|...|.:.|:   :|
Human  1086 SCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYL 1150

  Fly  1457 YSKDRNRHYYFMALRGEA-VIDATSKGNISRYINHSCDPN-AETQKWTVNGEL---RIGFFSVKP 1516
            :..|..        .||. .|||...|||||:|||.|||| ...:.:.::.:|   ||.|||.:.
Human  1151 FDLDNK--------DGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRD 1207

  Fly  1517 IQPGEEITFDY---------QYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDSDAEM 1572
            |:.|||:.|||         :|.       .|.|.:..|:         ...|.:..|....|.:
Human  1208 IRTGEELGFDYGDRFWDIKSKYF-------TCQCGSEKCK---------HSAEAIALEQSRLARL 1256

  Fly  1573 DEEELEAEPEEG 1584
            |... |..||.|
Human  1257 DPHP-ELLPELG 1267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	16/69 (23%)
		SET	1414..1533	CDD:214614	52/135 (39%)
		PostSET	1535..1551	CDD:214703	3/15 (20%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
EHMT2	XP_006715037.1	cond_enzymes	<46..>139	CDD:299129	25/98 (26%)
		Ank_2	711..798	CDD:289560	18/94 (19%)
		ANK	<711..762	CDD:295348	9/55 (16%)
		ANK	743..862	CDD:238125	26/122 (21%)
		ANK repeat	743..772	CDD:293786	7/32 (22%)
		Ank_2	779..872	CDD:289560	17/92 (18%)
		ANK	806..935	CDD:238125	17/133 (13%)
		ANK repeat	807..839	CDD:293786	5/31 (16%)
		ANK repeat	841..872	CDD:293786	5/30 (17%)
		ANK repeat	881..912	CDD:293786	3/30 (10%)
		Ank_5	901..954	CDD:290568	4/52 (8%)
		ANK repeat	914..945	CDD:293786	2/30 (7%)
		PreSET	987..1086	CDD:128744	13/101 (13%)
		SET	1102..1224	CDD:214614	51/129 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157957
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840