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Protein Alignment Set2 and Nsd2

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_001074571.2	Gene:	Nsd2 / 107823	MGIID:	1276574	Length:	1366	Species:	Mus musculus

Alignment Length:	1421	Identity:	296/1421 - (20%)
Similarity:	504/1421 - (35%)	Gaps:	411/1421 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 PEEDLDEIMVEVLSGPPSLWSADD-----EAEEEEDATVQRATPPGKEPAADSCSSAPRRSRRSA 426
            |.|.|.::...|.:|.|   .|.|     ||:|.:..    .|||...|..:.......:
Mouse    75 PAEKLKDLTSCVFNGEP---GAHDTKLCFEAQEVKGI----GTPPNTTPIKNGSPEIKLK----- 127

  Fly   427 PLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEE--------QHILID-LIEDTLSESEVT 482
             ::.:...||.|.|  :.|..:.:..:.::||::.:.:        :.|..| |:|..|.|:.:.
Mouse   128 -ITKTYMNGKPLFE--SSICGDGAADVSQSEENEQKSDNKTRRNRKRSIKYDSLLEQGLVEAALV 189

  Fly   483 SSV-SPTIEHMVVE-----------EVVVEEN---------------QLVDEADEILDSKQEFVI 520
            |.: ||..:.:.|:           :::::.|               ..:..||.:|.:..:...
Mouse   190 SKISSPADKKIPVKKESCPNTGRDRDLLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKG 254

  Fly   521 KK---------VFSESDNIAASLNKDI--FEPKVETKATCGEVVPRPEMVTEDVYITEGIAATL- 573
            :|         .|.::...|....|.:  ||.:.:.:..|.|...:.....|.:.:.:.|:..|
Mouse   255 QKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLR 319

  Fly   574 -----------------------------------------EKSAVVTKPTTEMIAETKLSDEVV 597
                                                     :::.:||:|..||:..:..|:|..
Mouse   320 AQWEMGIVQAEEAASMSIEERKAKFTFLYVGDQLHLNPQVAKEAGIVTEPLGEMVDSSGASEEAA 384

  Fly   598 IEP-PLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLET 661
            ::| .:::|..|.:.......|..|.|         .|.:..:....||:....|...|
Mouse   385 VDPGSVREEDIPTKRRRRTKRSSSAEN---------QEGDPGTDKSTPPKMAEAEPKRG------ 434

  Fly   662 SLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCN 726
                            :.:.|.::.|..:||.....:|:.:  ||:...:...|.|||..
Mouse   435 ----------------VGSPAGRKKSTGSAPRSRKGDSAAQ--FLVFCQKHRDEVVAEHP----- 476

  Fly   727 NQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTK-GTVP 790
            :..|:      |::|........:::|:||..|...|.......:..:|....|....|| ...|
Mouse   477 DASGE------EIEELLGSQWSMLNEKQKARYNTKFSLMISAQSEEDSGNGNGKKRSHTKRADDP 535

  Fly   791 EKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQL 855
            .:.:|.:.:     |.|:..:.|.:    |:|:.|              |:..|   ||
Mouse   536 AEDVDVEDA-----PRKRLRADKHS----LRKQRE--------------TITDK---TA------ 568

  Fly   856 QTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAM 920
                ::|:....|:|.|:.|:             ||.|.|||...|  ||.:.:|.:
Mouse   569 ----RTSSYKAIEAASSLKSQ-------------AATKNLSDACKP--LKKRNRASA-------- 606

  Fly   921 FKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSP 985
                                                 ||....|..||.|...||..:.| .|||
Mouse   607 -------------------------------------TASSALGFNKSSSPSASLTEHEV-SDSP 633

  Fly   986 NLERNSSP--SSDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTREVAASSP 1048
            ..|.:.||  |:|..|...|   :...|.::.:..::..:|:..:     .:.|....|......
Mouse   634 GDEPSESPYESADETQTEAS---VSSKKSERGMAAKKEYVCQLCE-----KTGSLLLCEGPCCGA 690

  Fly  1049 VSTSSDSSSKRNGSKRTTSDLDGG---------SKLDQRRYTI--CEDRQPETAI-PVPLT---K 1098
            ...:....|:|...:.|.::...|         ||::.:|..:  |.....|..: ..|||   .
Mouse   691 FHLACLGLSRRPEGRFTCTECASGIHSCFVCKESKMEVKRCVVNQCGKFYHEACVKKYPLTVFES 755

  Fly  1099 RRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSA 1163
            |.|..       |||..:...|......:..|..:.|   ......|..|.....|...:.|.|.
Mouse   756 RGFRC-------PLHSCMSCHASNPSNPRPSKGKMMR---CVRCPVAYHGGDACLAAGCSVIASN 810

  Fly  1164 ALLETESSESTSSGSKMSRWDVQTSPELEAANPFGDI-------AKFIEDGVNLLKRD------K 1215
            :::.|  ...|:...|.....|..| .....:..|.:       |.|..|.:|:...|      .
Mouse   811 SIICT--GHFTARKGKRHHTHVNVS-WCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCND 872

  Fly  1216 VDEDQRKEGQDEVKREADPEEDEFAQRVANME-TPATTPTPSPTQSNPEDSASTTTVLKELETGG 1279
            ....::...||.:           ..::.|.. .||....|.....|.:
Mouse   873 CRAGKKLHFQDII-----------WVKLGNYRWWPAEVCHPKNVPPNIQ---------------- 910

  Fly  1280 GVRRSHRIKQKP---------------------QGPRASQGRGVASVA-LAPISMDEQLAELANI 1322
              :..|.|.:.|                     :|.|.|:.:||..:. :...::.|..|.
Mouse   911 --KMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEAR---- 969

  Fly  1323 EAINEQFLRSEGLNT---------FQLLKENF-YRCARQVSQENAEM-QCDCFLTGDEEAQGHLS 1376
              .||..|:.|...|         ::.:|.|. |...:..:.:.:|: :|:|..| ||.     .
Mouse   970 --FNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPT-DEN-----P 1026

  Fly  1377 CGAG--CINRMLMIECGP-LCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIM 1438
            ||:.  |:|||||.||.| :|..|..|.|:.|.:.|....::.:|:.||.|:.|:..|..|||:.
Mouse  1027 CGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVN 1091

  Fly  1439 EYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTV 1503
            |||||:||.||...|.....::...|:|.:.:..:.:|||..|||.||::||||.||.||.||||
Mouse  1092 EYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTV 1156

  Fly  1504 NGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDS 1568
            ||:.|:|.|:|..|..|.|:||:|.....|.:...|.|.|:||.|::|..|            .:
Mouse  1157 NGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRP------------KT 1209

  Fly  1569 DAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKRKEQTKPKDREYKAG 1624
            .|.:..|      |:|:       |||.|.:.:.....|:::.|     |..::.|
Mouse  1210 SASLSSE------EKGK-------KAKKKTRRRRAKGEGKRQSE-----DECFRCG 1247

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.