DRSC/TRiP Functional Genomics Resources

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Protein Alignment Set2 and Kmt2b

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:XP_038949797.1 Gene:Kmt2b / 102550344 RGDID:7678027 Length:2714 Species:Rattus norvegicus


Alignment Length:2769 Identity:513/2769 - (18%)
Similarity:796/2769 - (28%) Gaps:998/2769 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SGPPSNPSPVASRGRGRGRPPKV----ALSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSEC 64
            :|..|.|.|.::|||..|||...    .....|:....:..:|:.....|.|...|..:.     
  Rat     5 AGGGSCPGPGSARGRFPGRPRGSGGGGGRGGRGSGAERVRVALRRGGGAAGPGGAEPGED----- 64

  Fly    65 RRSSRKKIIKFDVRDLLNKNRKAHKIQIEARI--------------------DSNPSTGHSQ--- 106
              ::..:::     .|....|:..::...||:                    :...|.|.|:   
  Rat    65 --TALLRLL-----GLRRGLRRLRRLWAGARVQRGRGRGRGRGWGPNRGCMPEEESSDGESEEEE 122

  Fly   107 -----SGTTAASTSMSTATASAASASSAATVSRLFSMFEMSHQSLP-PP------PPPPTALEIF 159
                 |....|.:|:.:|..|....:......:        |::.| ||      |.||.|....
  Rat   123 FQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRK--------HKTTPLPPRLADVAPAPPKAPTRK 179

  Fly   160 AKPRPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRK-RGRP--------RKSQ----LADA 211
            .....|:.::.|.......|.....|........|.|||: ||||        ||.|    :|:|
  Rat   180 KGEEGTERMVQALTELLRRARAPQPPRSRARAREPSTPRRSRGRPPGRPAGPCRKKQQAVVVAEA 244

  Fly   212 AII------PTVIVP--------SCSDSDTNSTSTTTSNMSSDSG-------ELPGFPIQKPKSK 255
            |:.      |..:||        .|.:.......|.........|       ...|.|:.   .|
  Rat   245 AVTIPKSEPPPPVVPVQHKAGSWKCKEGPGPGPGTPKRGGQPGRGGRGGRGRGRGGLPLM---IK 306

  Fly   256 LRVSLKRLKLGGRLESSDSGNSPSSSSPE-VEPPALQDENAMDERP---KQEQNLSRMVDAEENS 316
            .....|::|:|...:..:||......... .:.|..:|.:..:..|   ||||.|....:.:...
  Rat   307 FVSKAKKVKMGQLSQGLESGQGRGQRGESWQDAPQRRDGDEQERGPCRKKQEQKLEEEGEEKGEK 371

  Fly   317 DSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDLIDIDMELAKQE------------PTPDPEE 369
            :.||:        ::.|.:||::..|.|..|       ::.|||::            |.|.|..
  Rat   372 EDDSE--------DNSKQQEEEDTERAVAEE-------EVMLAKEKEEAKLPSPPLTPPVPSPPP 421

  Fly   370 DLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEPAADSCS----------SAPRRSRR 424
            .|.         |||                  .:||...|.....|          .||.:...
  Rat   422 PLP---------PPS------------------TSPPPASPLPPPVSPPPPPSPPPYPAPEKQEE 459

  Fly   425 SAPL---SGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLSESEVTSSV- 485
            |.||   :.|.::|:         ...:..|..|.|.::...|     ..:..|.:.|..|.|. 
  Rat   460 SPPLVPATCSRKRGR---------PPLTPSQRAEREAARSGPE-----GTLSPTANPSSTTGSPV 510

  Fly   486 --SPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFE-----PKV 543
              |||:               |.::...|.:.::|::..|.:.|..:..:..:.:.|     |||
  Rat   511 EDSPTV---------------VPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKV 560

  Fly   544 ETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDESDP 608
            |                          |::.:..|.|.|             :..:.|:...|.|
  Rat   561 E--------------------------ASIVRPPVATSP-------------LAPQEPVPVSSPP 586

  Fly   609 KQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENV 673
            :   |..|.|.| |.:|:..|.:..|                     |....|||:.        
  Rat   587 R---VPTPPSTP-VPLPEKRRSILRE---------------------PTFRWTSLTR-------- 618

  Fly   674 ETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFL-----------LEDYESNQEQVAEDEMMKCNN 727
            |..|.........|||.||    :..|..|..|           |:.|||               
  Rat   619 ELPPPPPAPPPAPSPPPAP----ATPSRRPLLLRAPQFTPSEAHLKIYES--------------- 664

  Fly   728 QKGQKQTPLP----EMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGT 788
                ..||.|    |..|||.|              ||..|||         |.|.:.|..|...
  Rat   665 ----VLTPPPLGALEAPEPELP--------------PADDSPA---------EPEPRAVGRTNHL 702

  Fly   789 -----VPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSS-SPNTLDKKGKD 847
                 ||          ...||.|.:.....|......::.:.::....|.:. .|..|..:   
  Rat   703 SLPRFVP----------VVTTPVKVEMPPHGAPALSEGQQLQLQQPPQALQTQLLPQALPPQ--- 754

  Fly   848 TAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVS 912
                .||:|..|.....||.|.     ::..|..|.|                          :|
  Rat   755 ----QPQMQPPPSPQHTPPLEK-----TRVASLGPLP--------------------------LS 784

  Fly   913 GFVECDAMFKAMDLANAQL-RLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLR 976
            |..|  .||..:..|..|| ::|::.:   :||...:...|.|:...||   |..|....:..:|
  Rat   785 GVEE--KMFSLLKRAKVQLFKIDQQQQ---QKVAASMPPSPAVQTEEAV---GTVKQTPDRGCVR 841

  Fly   977 RNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAA------------KD 1029
                          |...|..|:.:.::|...|.:     .||...:|..|            :|
  Rat   842 --------------SEDESMEAKRDGASGPESPVQ-----GPRIKHVCRHAAVALGQARAMVPED 887

  Fly  1030 LRSSSSSSTPTREVAASSPVSTSSDSSS--KRNGSKRTTSDLDGGSKLDQRRYTICEDRQPE-TA 1091
            :...|:.....|:..|:...|::|::.|  .|:..::..|...||            |.:|. :|
  Rat   888 VPRLSALPLRDRQDLATEDTSSASETESVPSRSQREKVESAGPGG------------DSEPTGSA 940

  Fly  1092 IPVPLTKRRF--SMHPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKK- 1153
            ..:..|.||.  |.|.|...       :...|..||....::..|..|.||....   |.|..| 
  Rat   941 GALAHTPRRSLPSHHGKKMR-------MARCGHCRGCLRVQDCGSCVNCLDKPKF---GGPNTKK 995

  Fly  1154 ---ALKSAEILSAALLETESSESTSSGSKMSRWDVQTSPELEAANP--------------FGDIA 1201
               ..:..:.:.|..:|..:.:..:....:..||...|||.....|              .|...
  Rat   996 QCCVYRKCDKIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGPREEVGATP 1060

  Fly  1202 KFIEDGVNLLKRDKV--------------DEDQRKEGQDEVKREADPEEDEFAQRVANMETPATT 1252
            ...|....||:|...              |.|..:.|.....|...|.|.|........::....
  Rat  1061 GPEEQDSLLLQRKSARRCVKQRPSYDVFEDSDDSEPGGPPAPRRRTPREHELPMLEPEEQSRPRK 1125

  Fly  1253 PTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAP-----ISM 1312
            ||..|...           ||      ..||..:....| ||.||...|......:|     :.:
  Rat  1126 PTLQPVLQ-----------LK------ARRRLDKDALAP-GPFASFPNGWTGKQKSPDGVHRVRV 1172

  Fly  1313 D-EQLAELANIEAINEQFLRSEGLNTFQ----------LLKENFYRCARQVSQENAEMQ--CD-- 1362
            | ::..:|.|:..:.       ||:...          ||      ||.:...|....|  ||  
  Rat  1173 DFKEDCDLENVWLMG-------GLSVLTSVPGGPPMVCLL------CASKGLHELVFCQVCCDPF 1224

  Fly  1363 ---CFLTGDEEAQGHLS----------------CGAGCINRMLMIEC-------GPLC---SNGA 1398
               |.    |||:..|.                ||........::||       .|.|   |...
  Rat  1225 HPFCL----EEAERPLPQHRDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPT 1285

  Fly  1399 RCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGE-FIMEYVGEVIDSEEFERRQHLYSK--- 1459
            |.|.:|  :|  |.|... ...|.||.|      ||: :.:|:.|   |.....|...||.|   
  Rat  1286 RATRRR--RH--WICSAC-VRCKSCGAT------PGKNWDVEWSG---DYSLCPRCTELYEKGNY 1336

  Fly  1460 ---------DRN-----------RHYYFMALRGEAVIDATSKGNISRYINHSCDP--NAETQKW- 1501
                     |.:           .|:......|.:..|......:...:.::|.|  .|...:| 
  Rat  1337 CPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGATQPRWR 1401

  Fly  1502 -TVNGELRIGFFSV-----------------------KPIQPG-----------EE--------- 1522
             .::|.|:.|...|                       |.:.||           ||         
  Rat  1402 EALSGALQGGLRQVLQGLLSSKVAGPLLLCTQCGQDGKQLHPGPCDLQAVGRRFEEGHYKSVHSF 1466

  Fly  1523 ----ITFDYQYLRYGRDAQR------------------CYCEAANCRGW-------IGGEPDSDE 1558
                :....::...|...:|                  |:.:|.:.:.|       .|..|::..
  Rat  1467 MEDVVAILMRHSEEGETPERRAGHQMKGLLLKLLESAFCWFDAHDPKYWRRSTRLPNGVLPNAVL 1531

  Fly  1559 GEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLP-LATGRKRKEQTKPKDREYK 1622
            ...||...   |:..::|.|. ||.|||.....|..:||..|... |...|:.....|..|.:.|
  Rat  1532 PPSLDHVY---AQWRQQESET-PESGQPPGDPSAAFQSKDPAAFSHLDDPRQCALCLKYGDADSK 1592

  Fly  1623 -AGRWLKPSATGSSSSAEKPPKKPKVNKFQAMLEDPDVVEELSLLRRGGLKNQQDTLR------- 1679
             |||.|   ..|.:....       ||   ..:...:|.||    ..|.|||....:.       
  Rat  1593 EAGRLL---YIGQNEWTH-------VN---CAIWSAEVFEE----NDGSLKNVHAAVARGRQMRC 1640

  Fly  1680 -------------FSRCLVRAKLLKTRLALLRVLTHGELPC---------------------RRL 1710
                         .|.||.....:..|.:........::.|                     ||:
  Rat  1641 ELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHTDLLDGKEIVTPDGFDVLRRV 1705

  Fly  1711 FLDYHGLRLLHAWISENGNDDQLREALLDTLESLPIPNRTMLSD------------SRVYQSVQL 1763
            ::|:.|:.....:::  |.:..:...|:.::....:...:.|||            ||:|     
  Rat  1706 YVDFEGINFKRKFLT--GLEPDVINVLIGSIRINSLGTLSDLSDCEGRLFPIGYQCSRLY----- 1763

  Fly  1764 WSNSLEQQLAVVPQEKQAALHKRMVALLQKWQALPEIFRIPKRERIEQMKEHEREADRQQKHVHA 1828
            ||         ....::...::..:...:.|.        |:.|.:     |...|:..|..||:
  Rat  1764 WS---------TVDARRRCWYRCRILEYRPWG--------PREEPV-----HLETAEENQTIVHS 1806

  Fly  1829 STALEDQRERESSNDR--------------------FRQDRFR------RDTTSSRIGKPIRMSG 1867
            .....:....:...|.                    .|.|...      |..:.:||..|.....
  Rat  1807 PAPSSEPPNHDDLPDTDSLVPGDPVHLSPIQNLDPPLRTDSSNGPPPTPRSFSGARIKVPNYSPS 1871

  Fly  1868 NNTICTITTQQKGSNGAPDGMTRN-----DNRRRSDI-GPPSEQRRTLSKELRRSLFERKVALDE 1926
            ...:..::.....|.|:|..:|.:     |    ||. .||...||......|          ..
  Rat  1872 RRPLGGVSFGPLPSPGSPSSLTHHIPTVGD----SDFPAPPRRSRRPSPLATR----------PP 1922

  Fly  1927 AERRVCTEDRLEHELRCEFFGADINTDPKQLPFYQKTDTNEWFNSDDVPVPAPPRTELLTKALLS 1991
            ..||..:..|...:||.          |........| :.|....|..|.|.||..:      |.
  Rat  1923 PSRRTSSPLRTSPQLRV----------PLSTSVLTPT-SGELAPPDLAPSPLPPSED------LG 1970

  Fly  1992 PDID-----VGQGATDVEYKLP-PGVDPLPP------AWNWQVTSDGDIYYYNLRERISQWEPPS 2044
            ||.:     .|..|.|:::... .|.:|...      |........||          |..|..|
  Rat  1971 PDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSQGGPGD----------SSEEEAS 2025

  Fly  2045 PEQRL----------QTLLEENTTQQPLHELQID-------------------------PAV--- 2071
            |..|.          .||...:....|..| |:|                         |||   
  Rat  2026 PTTRYVHFPVTVVSGPTLASSSLAGAPRIE-QLDGVDDGTDSEAEAVQQPRGQGTPPSGPAVGRG 2089

  Fly  2072 ---------------LENELIQVDTDYVGSLSAKSLAQYIEAKVRERRDLRRSKLVSIRLISPRR 2121
                           |.:|::    |:|    .|:|....|.....|.|       |:....|..
  Rat  2090 GVLGAAGDRARPPEDLPSEIV----DFV----LKNLGGPGEGAAGPRED-------SLPSAPPLA 2139

  Fly  2122 DEDRLYNQLESRKYKENKEKIRRRKELYRRRKIEVLPDA----------VDEIPVPGKALPI--- 2173
            :..:....|.:......             |....||.|          ..|.|.|..:..|   
  Rat  2140 NGSQPPQSLSTNPADPT-------------RTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVN 2191

  Fly  2174 ---QPYLFSSDEEETKVAAIEQPA-----AEEEQDSLNMAPSTSHAAMAALGKAVAQPTGLGTVG 2230
               |.::..:.|.|..|..::||:     ......|..:.|....:.:..:|..|.:|.      
  Rat  2192 KLGQVFVKMAGEGEPVVPPVKQPSLPPIIPPTAPTSWTLPPGPLLSVLPVVGVGVVRPA------ 2250

  Fly  2231 KRKLPMPPSVTV-------KKHRQEQRSKKVK--SSQSP 2260
              ..|.||.:|:       ...||..|.|:|.  |.:||
  Rat  2251 --PPPPPPPLTLVFSSGPPSPPRQAIRVKRVSTFSGRSP 2287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 19/84 (23%)
SET 1414..1533 CDD:214614 30/193 (16%)
PostSET 1535..1551 CDD:214703 4/40 (10%)
WW 2014..2043 CDD:278809 5/34 (15%)
SRI 2270..2348 CDD:285448
Kmt2bXP_038949797.1 zf-CXXC 956..1003 CDD:366873 11/56 (20%)
PHD1_KMT2B 1202..1248 CDD:277064 13/55 (24%)
PHD2_KMT2B 1250..1299 CDD:277066 13/52 (25%)
PHD3_KMT2B 1336..1392 CDD:277068 5/55 (9%)
Bromo_ALL-1 1373..1515 CDD:99925 18/141 (13%)
ePHD_KMT2B 1580..1684 CDD:277164 22/120 (18%)
FYRN 1732..1779 CDD:399155 8/60 (13%)
PHA03247 <1807..2315 CDD:223021 100/559 (18%)
FYRC 2412..2496 CDD:197781
SET_KMT2A_2B 2561..2714 CDD:380947
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166352014
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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