Protein Alignment Set2 and ezh1

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_031750333.1
• Gene: ezh1 / 100493532
• XenbaseID: XB-GENE-1010736
• Length: 793
• Species: Xenopus tropicalis
• Alignment Length: 930
• Identity: 183/930 - (19%)
• Similarity: 299/930 - (32%)
• Gaps: 359/930 - (38%)

  Fly   714 QEQVAEDEMMKCNNQKGQKQTPLP----EMKEPEKPVAETV---------SKKEKAMENPARSSP 765
            |..:.|||.:.||         :|    |:||.::...|.:         .::|..:::...|||
 Frog   135 QNFMVEDETVLCN---------IPYMGDEVKEEDETFIEELINNYDGKVHGEEELDLKSTMLSSP 190

  Fly   766 AIVDKK--VRAGEM----EKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKET 824
            .:.|::  .|.|:.    ....:|:..|.:.:                  .|.....||:|:...
 Frog   191 RLHDRERLFRFGQSFSSGRNSTIKTGSGLLDD------------------ASFLELMEALLQYTD 237

  Fly   825 EKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQH 889
            |:||   .|..|:    :.||::..:                             ..|..::.:.
 Frog   238 EEEK---WLSYST----EGKGEEVKE-----------------------------EGPMTRKRKR 266

  Fly   890 AAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKV 954
            .|::|            .::.....:..|.:|.|:.....:....|:.||:.|::....:  |..
 Frog   267 IAEEG------------SKRVCRSLLPNDLIFSAISAVFPERGFPEEVKKRYKELTEAYD--PNA 317

  Fly   955 EPPTAVP-VPGQ-KKSLSGKTSL--------RRNTVYE-------DSPNLERNSSPSSDSAQANT 1002
            .||...| :.|. .||:..:.||        ||...|:       .|||:.|.
 Frog   318 LPPQCTPNIDGPCAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHASPNVYRR------------ 370

  Fly  1003 SAGKLKPSKVKKKINPRRSTIC--------EAAKDL------RSSSSSSTPTREVAASSPVSTSS 1053
                 :..::|.:..|     |        |.||:.      ||........:..|.::..|.|:
 Frog   371 -----RNREIKIETEP-----CGIHCFLWLEGAKEYAMMNNPRSKCLGRRRRKTTALAASGSNSN 425

  Fly  1054 DSSSKRNGSKRTTSD--LDGGSKLDQRRYTICEDRQ-------PETAIPVPLTKRRFSMHPKASA 1109
            ...:|...|.|.|.:  ....|:.:.|..|..:.||       |:.:.|               :
 Frog   426 VMETKEGDSDRDTGNDCASSSSEANSRSQTPTKQRQGSLSGELPDVSEP---------------S 475

  Fly  1110 NPLHDTLLQTAGKKRGRKEGKESLSRQ------NSLDSSSSASQGAPKKKALKSAEILSAALLET 1168
            .|     ::.:|       .:|||.|.      |:. .|.:...|....|.:....:..:.||:.
 Frog   476 EP-----VEWSG-------AEESLFRVFHGTYFNNF-CSIARLMGTKTCKQVFQFAVTDSLLLKV 527

  Fly  1169 ESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREAD 1233
            .:.|..|:..|..|     ...|.||:                                 .|:..
 Frog   528 PAKELMSTAQKKKR-----KHRLWAAH---------------------------------CRKIQ 554

  Fly  1234 PEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQ 1298
            .::|..|.:|.|.:       |.....:|.||.
 Frog   555 LKKDNSANQVYNYQ-------PCDHPDHPCDST-------------------------------- 580

  Fly  1299 GRGVASVALAPISMDEQLAE---LANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQ 1360
                     .|..|.:...|   ..|.:..|    |..|.           ||..|.:.:    |
 Frog   581 ---------CPCIMTQNFCEKFCQCNPDCQN----RFPGC-----------RCKTQCNTK----Q 617

  Fly  1361 CDCFLTGDEEAQGHLSCGAGCINRMLMIECGP-LC-SNGARCTNKRFQQH------QCWPCRVFR 1417
            |.|:|.                    :.||.| || :.||       .:|      .|..|.:.|
 Frog   618 CPCYLA--------------------VRECDPDLCLTCGA-------SEHWDSKVVSCKNCSIQR 655

  Fly  1418 TEKK----------GCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRG 1472
            ..||          |.|...:..:...|||.||.||:|..:|.:||..:|  |:....:...|..
 Frog   656 GLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVY--DKYMSSFLFNLNN 718

  Fly  1473 EAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQ 1537
            :.|:|||.|||..|:.|||..||...:...|||:.|||.|:.:.||.|||:.|||:|
 Frog   719 DFVVDATRKGNKIRFANHSVHPNCYAKVVMVNGDHRIGIFAKRTIQAGEELFFDYRY-------- 775

  Fly  1538 RCYCEAANCRGWIGGEPDSD 1557
                ..|:...::|.|.::|
 Frog   776 ----SQADALKYVGIERETD 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	27/136 (20%)
		AWS	1358..1410	CDD:197795	12/59 (20%)
		SET_SETD2	1410..1551	CDD:380949	51/150 (34%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
ezh1	XP_031750333.1	EZH2_WD-Binding	55..84	CDD:463308
		PRC2_HTH_1	216..311	CDD:436286	22/160 (14%)
		SANT	479..520	CDD:238096	9/48 (19%)
		preSET_CXC	606..637	CDD:408079	13/65 (20%)
		SET_EZH1	654..789	CDD:380994	51/148 (34%)