DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and ezh1

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_031750333.1	Gene:	ezh1 / 100493532	XenbaseID:	XB-GENE-1010736	Length:	793	Species:	Xenopus tropicalis

Alignment Length:	930	Identity:	183/930 - (19%)
Similarity:	299/930 - (32%)	Gaps:	359/930 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   714 QEQVAEDEMMKCNNQKGQKQTPLP----EMKEPEKPVAETV---------SKKEKAMENPARSSP 765
            |..:.|||.:.||         :|    |:||.::...|.:         .::|..:::...|||
Frog   135 QNFMVEDETVLCN---------IPYMGDEVKEEDETFIEELINNYDGKVHGEEELDLKSTMLSSP 190

  Fly   766 AIVDKK--VRAGEM----EKKVVKSTKGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKET 824
            .:.|::  .|.|:.    ....:|:..|.:.:                  .|.....||:|:...
Frog   191 RLHDRERLFRFGQSFSSGRNSTIKTGSGLLDD------------------ASFLELMEALLQYTD 237

  Fly   825 EKEKSSAKLDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQH 889
            |:||   .|..|:    :.||::..:                             ..|..::.:.
Frog   238 EEEK---WLSYST----EGKGEEVKE-----------------------------EGPMTRKRKR 266

  Fly   890 AAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKV 954
            .|::|            .::.....:..|.:|.|:.....:....|:.||:.|::....:  |..
Frog   267 IAEEG------------SKRVCRSLLPNDLIFSAISAVFPERGFPEEVKKRYKELTEAYD--PNA 317

  Fly   955 EPPTAVP-VPGQ-KKSLSGKTSL--------RRNTVYE-------DSPNLERNSSPSSDSAQANT 1002
            .||...| :.|. .||:..:.||        ||...|:       .|||:.|.
Frog   318 LPPQCTPNIDGPCAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHASPNVYRR------------ 370

  Fly  1003 SAGKLKPSKVKKKINPRRSTIC--------EAAKDL------RSSSSSSTPTREVAASSPVSTSS 1053
                 :..::|.:..|     |        |.||:.      ||........:..|.::..|.|:
Frog   371 -----RNREIKIETEP-----CGIHCFLWLEGAKEYAMMNNPRSKCLGRRRRKTTALAASGSNSN 425

  Fly  1054 DSSSKRNGSKRTTSD--LDGGSKLDQRRYTICEDRQ-------PETAIPVPLTKRRFSMHPKASA 1109
            ...:|...|.|.|.:  ....|:.:.|..|..:.||       |:.:.|               :
Frog   426 VMETKEGDSDRDTGNDCASSSSEANSRSQTPTKQRQGSLSGELPDVSEP---------------S 475

  Fly  1110 NPLHDTLLQTAGKKRGRKEGKESLSRQ------NSLDSSSSASQGAPKKKALKSAEILSAALLET 1168
            .|     ::.:|       .:|||.|.      |:. .|.:...|....|.:....:..:.||:.
Frog   476 EP-----VEWSG-------AEESLFRVFHGTYFNNF-CSIARLMGTKTCKQVFQFAVTDSLLLKV 527

  Fly  1169 ESSESTSSGSKMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREAD 1233
            .:.|..|:..|..|     ...|.||:                                 .|:..
Frog   528 PAKELMSTAQKKKR-----KHRLWAAH---------------------------------CRKIQ 554

  Fly  1234 PEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQ 1298
            .::|..|.:|.|.:       |.....:|.||.
Frog   555 LKKDNSANQVYNYQ-------PCDHPDHPCDST-------------------------------- 580

  Fly  1299 GRGVASVALAPISMDEQLAE---LANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQ 1360
                     .|..|.:...|   ..|.:..|    |..|.           ||..|.:.:    |
Frog   581 ---------CPCIMTQNFCEKFCQCNPDCQN----RFPGC-----------RCKTQCNTK----Q 617

  Fly  1361 CDCFLTGDEEAQGHLSCGAGCINRMLMIECGP-LC-SNGARCTNKRFQQH------QCWPCRVFR 1417
            |.|:|.                    :.||.| || :.||       .:|      .|..|.:.|
Frog   618 CPCYLA--------------------VRECDPDLCLTCGA-------SEHWDSKVVSCKNCSIQR 655

  Fly  1418 TEKK----------GCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRG 1472
            ..||          |.|...:..:...|||.||.||:|..:|.:||..:|  |:....:...|..
Frog   656 GLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVY--DKYMSSFLFNLNN 718

  Fly  1473 EAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQ 1537
            :.|:|||.|||..|:.|||..||...:...|||:.|||.|:.:.||.|||:.|||:|
Frog   719 DFVVDATRKGNKIRFANHSVHPNCYAKVVMVNGDHRIGIFAKRTIQAGEELFFDYRY-------- 775

  Fly  1538 RCYCEAANCRGWIGGEPDSD 1557
                ..|:...::|.|.::|
Frog   776 ----SQADALKYVGIERETD 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	12/59 (20%)
		SET	1414..1533	CDD:214614	48/128 (38%)
		PostSET	1535..1551	CDD:214703	1/15 (7%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
ezh1	XP_031750333.1	EZH2_WD-Binding	58..84	CDD:402972
		PRC2_HTH_1	216..311	CDD:407952	22/160 (14%)
		SANT	479..520	CDD:238096	9/48 (19%)
		preSET_CXC	606..637	CDD:408079	13/65 (20%)
		SET_EZH1	654..789	CDD:380994	51/148 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000