DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and setdb1

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	NP_001238764.2	Gene:	setdb1 / 100490309	XenbaseID:	XB-GENE-853380	Length:	1282	Species:	Xenopus tropicalis

Alignment Length:	1397	Identity:	250/1397 - (17%)
Similarity:	465/1397 - (33%)	Gaps:	420/1397 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 LEAEESQDQEEQHI---------LIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEAD 509
            ::::|:.:.|:..:         |.:||:..|.:.|........:  :.:|::|.::...||..|
Frog     1 MDSQETMELEQMVVKELGISMDDLHELIDRELEKIEFVKQRKAQL--LELEQLVKQKEAEVDHVD 63

  Fly   510 EILDSKQ------EFVIKKVFSESDNIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEG 568
            ::.|:..      |.::|.::::   |..:..:...|.:..:|..  ||:..|:...:|| ::.|
Frog    64 KLFDNATRAVDDCEMLVKSLYNQ---IGMTYKESSSEDEGSSKPV--EVIEIPDEDDDDV-MSVG 122

  Fly   569 IAATLEKSAVVTKPTTEMIAETKLSDEVV--IEPPLKDESDPKQTEVELPESKPAVNIPKSERIL 631
            ....:.|.........|.:|..|.|.:.|  |...::.:||..||......|.|..::..|.:..
Frog   123 SGEAVSKIPKEKHLLREAMAAMKRSRQDVQSIVEAIQKKSDGPQTRFSSHPSSPTSSVGGSNQAS 187

  Fly   632 SAEVETTSSPLV----------------------------------------------------- 643
            ::...:....||
Frog   188 ASNDMSKDGDLVVGMRILGKKRTKTWHKGTLISIQCVGPGKKYKVKFDNKGKSLLSGNHIAYDYH 252

  Fly   644 -PPECCTLES-------VSGPVLLETSLSTEEKSNEN------------------VETTPL---- 678
             |||...:.|       ....|.|...:..|..||:|                  .|..|:
Frog   253 PPPENLVVGSRVVAKYKDGNQVWLYAGIVAEPPSNKNKMRYLIFFDDGYASYVTHAELYPVCRPL 317

  Fly   679 --KTEAAKEDSPPAAPEEEASNSSEEPNFLLED------------YESNQEQV---------AED 720
              ..|..::.|.....:|..:.....|..||:.            ::|..|:|         .:|
Frog   318 ISSWEDIEDVSCRDFIQEYVNAYPNRPMVLLKSGQLIKTEWEGTWWKSKVEEVDGSLVKILFLDD 382

  Fly   721 EMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKK--VVK 783
            :..:...:...:..|:..||      ..|.|.:||......|:.|.:       |.:..|  ||:
Frog   383 KRCEWIYRGSTRLEPMFSMK------TSTASTQEKKQAGQQRTRPNV-------GAIRSKGPVVQ 434

  Fly   784 ST---KGTVPEKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKG 845
            .|   .|:.||.|..:..|..::...:..::...:::|..||:..|:.:|.:..|:.
Frog   435 YTHDLTGSEPEPKPAAPPSPLSIPSPQLIDTDSDSQQAQSKKQVAKKSTSFRPGSAG-------- 491

  Fly   846 KDTAQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKA 910
              :.|.||    :|..|..||....|.|:.:       |.:...:.:...|..|..::...  :.
Frog   492 --SGQSSP----IPSESVPPPPPPPPPVVQR-------PFQSNQSVQPVQSIQSIQNIQTI--QT 541

  Fly   911 VSGFVECDAMFKAMDLANAQ--------------------LRLDEKNKKKLKKVP--TKVEAP-- 951
            :.|.....|:.....:...|                    ..:.:.:..:.:.||  |..:||
Frog   542 IQGIQTIQAIQPIQTIQTLQPIQTIQPLQTIQTLQGNRIVTSIQQIHIIQAENVPAETTYKAPKE 606

  Fly   952 --------------PKVEP-------PTAVPVPGQKKSLSGKTSLRR----NTVYEDSPNLERNS 991
                          .::.|       |..||:....:.::.:..:.|    :.:|:....|...:
Frog   607 KLFYLPHVCNYTCLSRIRPVSHRGKNPLLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLSLRT 671

  Fly   992 SPSSDSAQANTSAGKLKPSK--------VKKKINPRR-----STICEAAKDLRSSSSSS---TPT 1040
            .|..:..........|....        |.:|..|::     ..|....:|:..|..:.   ||.
Frog   672 MPEIERYLFEVECRMLFLEMFCLDPYVLVDRKFQPQKPFYYIPDITYGKEDVPLSCVNEIDRTPP 736

  Fly  1041 REVAASSP--------VSTSSD-------SSSKRNGSK----RTTSDLDG---GSKLD------Q 1077
            .:||.|..        ::|.::       :...|:.||    :.|....|   |::|:      .
Frog   737 PQVAYSKERIPGKGVFINTGAEYLVGCDCTDGCRDKSKCACHQLTIQATGCTPGAQLNPMAGYQH 801

  Fly  1078 RRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQ------------------------ 1118
            :|...|          :|......:...|.|||..::.|:|
Frog   802 KRLEEC----------LPTGVYECNKRCKCSANMCNNRLVQHGLQVRLQLFKTQNKGWGIRCLDD 856

  Fly  1119 ---------TAGK--------KRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALL 1166
                     .|||        |.|.:.|.|..:..:.::|..:..:|  .:...||:...|...|
Frog   857 IAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENYKEG--YESDAKSSSDSSGVDL 919

  Fly  1167 ETESSESTSSGSKMSRWDVQTSPELEAANPFG---DIAKFI---------------EDGVNLLKR 1213
            :.:..|:|.|       :.|......:.:.||   ||....               |:|.:
Frog   920 KDDDEENTGS-------EDQDESNDSSDDNFGKNEDITTSSVWRSYATRRQTRGQKENGTS---- 973

  Fly  1214 DKVDEDQ---RKEGQDEVKREADPEEDEFAQRVA---NMETPATTPTPSPTQSNPE-DSASTTTV 1271
            :...:|.   |:..|||......|||.. ..:||   :..|.|.:...|.::|:.: ..||.|..
Frog   974 ETASKDSALARQTSQDETTDCKLPEETS-KNKVASWLSSNTMADSLMDSDSRSSLKMGDASETDK 1037

  Fly  1272 LKELETGG---GVRRSHRIKQKPQGPRASQG--RGVASVALAPISMDEQLA----ELANIEAINE 1327
            .||.:...   |....:|:......|....|  |.|:..||.........|    |:..:.:.:|
Frog  1038 PKESDEASKYPGFGEGNRMYGYNPAPAKKDGVRRPVSKTALHQNKRQSNSAQPTDEVLTLSSSSE 1102

  Fly  1328 QFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGP 1392
            ..:.| |.|..:      ...|:..:.::.::|.....:.:||.:.:::..||.:.|.:.::
Frog  1103 SEVGS-GTNGTK------KPAAQATANDSDDIQTISSGSDEEEEKKNVATTAGPVKRQVAVK--- 1157

  Fly  1393 LCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLY 1457
                    :.:.|            ..|...|||.:..:..||      |.
Frog  1158 --------STRGF------------ALKSTHGITVKTNMASGE------GG-------------- 1182

  Fly  1458 SKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVN-GELR---IGFFSVKPIQ 1518
            :..||...:|.......:|||..:||:.||:||||.||...|...|: .:||   :.||:.|.|:
Frog  1183 TGRRNTRQFFDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIR 1247

  Fly  1519 PGEEITFDYQYLRYGRDAQR--CYCEAANCRG 1548
            .|.|:|:||.|.....:.::  |.|.:..|||
Frog  1248 AGTELTWDYNYEVGSVEGKKLLCCCGSTECRG 1279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	7/51 (14%)
		SET	1414..1533	CDD:214614	37/122 (30%)
		PostSET	1535..1551	CDD:214703	5/16 (31%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
setdb1	NP_001238764.2	DUF5604	193..250	CDD:408109	2/56 (4%)
		Tudor_SETDB1_rpt1	260..341	CDD:410453	12/80 (15%)
		Tudor_SETDB1_rpt2	348..401	CDD:410548	6/52 (12%)
		SP1-4_N	<515..>594	CDD:425404	6/87 (7%)
		MBD	631..706	CDD:128673	10/74 (14%)
		SET_SETDB1	708..>905	CDD:380915	34/208 (16%)
		MSCRAMM_ClfB	<918..1045	CDD:411414	30/138 (22%)
		SET	<1193..1282	CDD:394802	32/87 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910