Protein Alignment Set2 and ehmt2

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_004917185.1
• Gene: ehmt2 / 100484992
• XenbaseID: XB-GENE-487387
• Length: 1150
• Species: Xenopus tropicalis
• Alignment Length: 1232
• Identity: 247/1232 - (20%)
• Similarity: 401/1232 - (32%)
• Gaps: 430/1232 - (34%)

  Fly   626 KSERILSAEVETTSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPA 690
            :|||:||||.       ...|.|....:.|   |..|:::.:.:.|.:..|   .|.:..|..|.
 Frog     7 ESERMLSAEG-------ADKEGCPERDLVG---LSASINSGDDNAEELSNT---REISPADVIPT 58

  Fly   691 APEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKEPEKPVAETVSKKEK 755
            ..|:|               |:.:|.|....:.:..:....|..|.|    |....:...|:.:.
 Frog    59 VEEKE---------------ETEKESVNISPVGRGLSGHASKSLPTP----PSTSSSPISSRAKM 104

  Fly   756 AMENPARSSPAIVDKKVRAGEMEK----KVVKSTKGTVP----------------------EKKM 794
            ::....:...|.....:|...:.:    ||.::.| |:|                      |.:|
 Frog   105 SLTGTGKLPHAAQSLAMRLLNITRDGADKVHRARK-TIPRAVNVPGNGVLVSDGEKQSVRRESEM 168

  Fly   795 DSKKSCAAVTPAKQKESGKSAKEAILKKET-EKEKSSAKLDSSSPNTLDKKGKDTAQWSPQL--- 855
            :::.|    ..:.||.|..|....|...:: |.|.||..|.....::.|.:|.|..:|.|::
 Frog   169 ETRDS----PDSTQKRSSSSLVADISANQSREVEVSSLLLSPEPGSSRDPEGVDAEEWEPEVGAE 229

  Fly   856 -QTLPKSSTKPPQESAPSVISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDA 919
             .....|.:...|..:.|            |||:...::|..:.|..|....|:|..
 Frog   230 FSLFYDSFSLEEQGDSDS------------KEEEDEEEEGSGNQSERSSSSMKKKTK-------- 274

  Fly   920 MFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVE-------PPTAVPVPGQ------KKSLSG 971
              |...:..|.|:...|.|::.::.|....:...|.       |..|:.:|.:      ...:..
 Frog   275 --KKWKMDKAWLKPTRKRKRREREKPVTAVSSVGVSNSEYTEVPLGALDLPSEGTLSPNHAGVCN 337

  Fly   972 KTSLRRNTVYEDSPNLE-RNSSPSSDSA--QANTSA-------GKLKPSKV--KKKINPRRST-- 1022
            :||......||:.|... |..:||.|..  |||...       |:|....|  .|:...|.|:
 Frog   338 ETSSMDTERYEELPLCSCRMEAPSVDRVCEQANNMCMATESVDGELSGCNVTITKRETMRPSSRV 402

  Fly  1023 ----ICEAAKDLRSSSSSSTP-------TREVAASSPVSTSSDSSSKRNGSKRTTSDLDG----- 1071
                :||:.: .|.......|       |.......|     |........|...|.|:|
 Frog   403 PLMVLCESHR-ARMVKHHCCPGCGYFCTTGTFLECHP-----DFRINHRFHKACVSPLNGIIFCP 461

  Fly  1072 -----GSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHD-------TLLQTAGKKR 1124
                 .|:.:|  .||.   :.:|.:|:|             |.|.||       ...|.:.:.|
 Frog   462 HCGEDASEAEQ--ITIA---KADTPVPIP-------------APPHHDGGGPGRADTTQPSARMR 508

  Fly  1125 GRKEGKESLSRQNSLDSSSSAS-----------QGAPK-------KKALKSAEI----------- 1160
            |..|||.|.....|.:.....|           .|.|.       :|||:|.|.
 Frog   509 GVGEGKRSALENTSNEEPQGPSVLLHSGVYLSTAGLPPGHARDALEKALQSQETDSLLQGRNCHS 573

  Fly  1161 LSAALLE--------------------------------TESSES-------------------- 1173
            |:.:||:                                .::.:|
 Frog   574 LTESLLQQKRDRRKKIRYNSRQLYLSVKQGELQKVLLMLMDNQDSNFLNDQQLKRSPLHAAAQRG 638

  Fly  1174 --------TSSGSKMSRWD-VQTSPELEA-ANPFGDIAKFI-----------EDGVN-------- 1209
                    ..:|:.::..| |..:|.||| .|...||||::           |||..
 Frog   639 SLELCHILVQAGASINSTDKVLRTPLLEAVVNNHIDIAKYLVQCGACVYHKEEDGSTCLHHAAKS 703

  Fly  1210 --------LLKRDKVDEDQRKEG-----------------------------QDEVKR-----EA 1232
                    ||...:|:.:.:..|                             ||..|.     .:
 Frog   704 GNLELLCFLLSTGQVNVNAQDNGGWTPIIWAAEHKHIDVIRTLLTRGADVTLQDNEKNICLHWAS 768

  Fly  1233 DPEEDEFAQRVANM-----------ETP----------------ATTPTPSPTQSNPEDSASTTT 1270
            .....|.|:.:.|.           :||                .:....:..::|..|:....|
 Frog   769 FTGSAEIAEVLLNAQCDLHAVNFHGDTPLHIASREGFIQCVNLFLSRGADTEIRNNEGDTPCDLT 833

  Fly  1271 VLKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALA------PI----SMDEQLAELANIEAI 1325
             |:..:....::.:.:|:|.... ||.:...:.|..:|      ||    .:||:|..
 Frog   834 -LEHTDVWYALQLNRKIRQGINN-RAVRTERIISRDIAHGYERVPIPCVNGVDEELCP------- 889

  Fly  1326 NEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQ-CDCFLTGDEEAQGHLSCGAGCI------- 1382
                      :.::.:.||....|..:.:....:| |.|.   |:.:..:..||...|
 Frog   890 ----------DDYKYVSENCETSAMSIDRNITHLQNCSCV---DDCSSSNCLCGQLSIRCWYDKD 941

  Fly  1383 -------NRM---LMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFI 1437
                   |::   |:.||...||....|.|:..|.......:::||.|.|.|:.|...||.|.||
 Frog   942 GRLLQEFNKIEPPLIFECNQACSCWQTCKNRVVQSGIKVRLQLYRTAKMGWGVRALQAIPQGTFI 1006

  Fly  1438 MEYVGEVIDSEEFERRQ---HLYSKDRNRHYYFMALRGEA-VIDATSKGNISRYINHSCDPN-AE 1497
            .|||||:|...|.:.|:   :|:..|..        .||. .|||...||:||:|||.|:|| ..
 Frog  1007 CEYVGELISDAEADVREDDSYLFDLDNK--------DGEVYCIDARYYGNVSRFINHLCEPNLIP 1063

  Fly  1498 TQKWTVNGEL---RIGFFSVKPIQPGEEITFDY---------QYLRYGRDAQRCYCEAANCR 1547
            .:.:..:.:|   ||.|||.:.|:.|||:.|||         :|.       .|.|.:..|:
 Frog  1064 VRVFMSHQDLRFPRIAFFSGRDIRAGEELGFDYGDRFWDIKSKYF-------TCQCGSERCK 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	27/149 (18%)
		AWS	1358..1410	CDD:197795	16/69 (23%)
		SET_SETD2	1410..1551	CDD:380949	53/155 (34%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
ehmt2	XP_004917185.1	EHMT_ZBD	348..477	CDD:411018	30/139 (22%)
		ANKYR	574..861	CDD:440430	39/288 (14%)
		ANK repeat	628..657	CDD:293786	1/28 (4%)
		ANK repeat	659..690	CDD:293786	10/30 (33%)
		ANK repeat	692..724	CDD:293786	5/31 (16%)
		ANK repeat	727..757	CDD:293786	0/29 (0%)
		ANK repeat	759..790	CDD:293786	4/30 (13%)
		ANK repeat	792..823	CDD:293786	2/30 (7%)
		SET_EHMT2	890..1128	CDD:380931	72/247 (29%)