Protein Alignment Set2 and Kmt2d

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_063118908.1
• Gene: Kmt2d / 100362634
• RGDID: 2324324
• Length: 5565
• Species: Rattus norvegicus
• Alignment Length: 1954
• Identity: 362/1954 - (18%)
• Similarity: 618/1954 - (31%)
• Gaps: 692/1954 - (35%)

  Fly   143 HQSLPPPPPPPTALEIFAKPRPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVT-------PRKR 200
            :|:|.|.|      :....|...|.|:|.|::.:.|.  |:   |.|.|...|.       .:::
  Rat  3757 NQALGPKP------QGLLPPSNHQGLLVQQLSPQQSQ--GS---QGMLGSSQVAVLQQQQQQQQQ 3810

  Fly   201 GRPRKSQLADAAIIP-----TVIVPSCSDSDTNSTSTTTSNMSSDSGELPGFPI------QKPKS 254
            .:.::.|....|:.|     .|::       |.|...::..::.....|.|..:      |:.:.
  Rat  3811 QQQQQQQQHSGALGPQGPHRQVLM-------TQSRVLSSPQLAQQGHGLMGHRLLTAQQQQQQQQ 3868

  Fly   255 KLRVSLKRLKLGGR--LESSDSGNSPSSSSPEVEPPAL-------QDENAMDERPKQEQNLSRMV 310
            :.:...::.:.|..  |.....|.......|::...||       |.:..:.::.:|.|.|.:..
  Rat  3869 QQQQQQQQQQQGSMTGLSQLQQGMMSHGGQPKMSVQALGSLQQQQQQQQQLQQQQQQMQQLQQQQ 3933

  Fly   311 DAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDL--DE 373
            ..:.......|:..::.:.:..:.:::|:       :.|..:.:..:|.:|:.....:..|  .:
  Rat  3934 QQQLQQQQQQQMQQLQQQQQQLQQQQQQQ-------QQQQQLHLQQQLHQQQQLQQQQLQLQQQQ 3991

  Fly   374 IMVEVLSGPPSLWSADDEAEEEEDAT---------VQRATPPG---------------KEPAADS 414
            ..:.:|:...:|.|...:.::::..|         :|..:.||               .|.|..|
  Rat  3992 QQMSLLNQNRTLLSPQQQQQQQQQVTLGPGMPVKPLQHFSSPGALGPALLLTGKEQNIAETALPS 4056

  Fly   415 -CSSAPRRSRRSAPLSGSSRQGKTLE--ETFAEIAAESSKQILEAEESQDQEE-------QHILI 469
             .:..|...:...|..|::.:..::|  |....|:.:|...:::::.:..|.:       |...:
  Rat  4057 EVTEGPSAHQGGPPTVGTTPESMSVEPGEVKPSISGDSQLLLVQSQPTSVQLQPPLRLPGQPQQV 4121

  Fly   470 DLIEDTLSES------EVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESD 528
            :|:..|...|      ..:||.:|:..|::.:..|....|....|..:|.|:|...:::....
  Rat  4122 NLLHTTGGGSHGQQLGSGSSSEAPSGPHLLAQPSVSLGEQPGPMAQNLLGSQQPLGLERPIQN-- 4184

  Fly   529 NIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLS 593
                  |.....||.......|:..|                      .|...||...: ..:|.
  Rat  4185 ------NTGSQPPKSGPAPQSGQGPP----------------------GVGVMPTVGQL-RAQLQ 4220

  Fly   594 DEVVIEPPLKDESDPKQTEV-------ELPESKPAVNIPKSER-------------------ILS 632
            ..:...|.|:..|..:|.::       :|.:|:....:|..:.                   :.|
  Rat  4221 GVLAKTPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQMPPGQESGTQPSPLQGLLGCQPQPGVFS 4285

  Fly   633 A-------EVETTSSPLVPPECCTLESV--SGPVL------LETSLSTEEK-----SNENVETTP 677
            |       |:...|.|..||.....:..  :||||      ...|...|.|     .:.:.:.||
  Rat  4286 ASQIGPLQELGAGSRPQGPPRLPVPQGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSAQLTP 4350

  Fly   678 L-----KTEAAKEDSPPAAPEEEASNSSE----------EP-NFLLEDYESNQEQVAEDEMMKCN 726
            .     |.:....:.||......|:..::          :| :.|.|..:..|..:|...:.:.|
  Rat  4351 THPGTPKPQGPASELPPGRVSPAAAQLADAFFGKGLGPWDPSDNLPEAQKPEQSSLAAGRLEQVN 4415

  Fly   727 NQKGQKQTPLPEMKEP-EKPV---AETVSKKEKAMENPARSSPAIVDKKVRAGE----------- 776
            .|...:.:.|...:|| |:|.   |:||  |.:|...|| .:|...:..:.||.
  Rat  4416 GQVAHEPSHLSIKQEPREEPCALGAQTV--KREANGEPA-GAPGTSNHLLLAGSRSEAGHLLLQK 4477

  Fly   777 -MEKKVVKSTKGTVPE-------KKMDSKKSCAAVTPAKQKESGKS-------AKEAILKKETEK 826
             :..|.|:...|..||       ..:|||     ::..:||..|.|       |::.::.|....
  Rat  4478 LLRAKNVQLGAGRGPEGLRAEINGHVDSK-----LSGQEQKLQGTSSSKEDAAARKPLMAKPKRV 4537

  Fly   827 EKSSAKLDSSSPNTLDKKGKDT-----AQWSPQLQTLPKSSTKPPQESAPSVISKTTSNQPAPKE 886
            :|:|.:|.||......:.|...     .|...:|..||.:.        |::.:..:...|...
  Rat  4538 QKTSDRLASSRKKLRKEDGVRANEALLKQLKQELSQLPLTE--------PTITANFSLFAPFGS- 4593

  Fly   887 EQHAAKKGLSDNSPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAP 951
                           ..|...:..:.|.....|:....|..:..|     .|..|...||    |
  Rat  4594 ---------------GCLVGGQSQLRGAFGSGALHTGPDYYSQLL-----TKNNLSNPPT----P 4634

  Fly   952 PKVEPPTAVPVPG-QKKSLSGKTSLRRNTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKK 1015
            |...|||  |.|. |:|.::|.|           |:.|....| .|:|.|..|...||.:...|.
  Rat  4635 PSSLPPT--PPPSVQQKMVNGVT-----------PSEELGEHP-KDAASAQDSERTLKDAAEVKS 4685

  Fly  1016 IN--------PRRSTICEAAKDLR--SSSSSSTPTREVAASSPVSTSSDSSSK--RNGSKRTTSD 1068
            ::        |...|     :|:|  |...|.:|...|.||||.|...:.:.:  :.||
  Rat  4686 LDLLAALPTPPHNQT-----EDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPQLGS------ 4739

  Fly  1069 LDGGSKLDQRRYTICEDRQPETAIPV-PLTKRRFSMHPKASANPLHDTLLQTAGK------KRGR 1126
              |..:.|.|..:......|.|:||| |.||            |.....|:..||      ::|:
  Rat  4740 --GRWEQDTRALSPVIPIIPRTSIPVFPDTK------------PYGVLDLEVPGKPPATAWEKGK 4790

  Fly  1127 KEGKE-------SLSRQNSLDSSSSASQGAPKKKALKSAEIL-----SAALLETESSESTSSGSK 1179
              |.|       |.:...:|:....|.......|...|.|:|     :.|.||.:..|:..||.|
  Rat  4791 --GSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPDGPARAGLEPKKGETEGSGGK 4853

  Fly  1180 ---MSRWDVQTSP----ELEAANPFGDIAKFIEDGVNLLKRD-----------------KVDEDQ 1220
               :|.....|.|    :.:|..| |...|...|.::|||::                 .:|..|
  Rat  4854 EKGLSGRGPDTGPDWLKQFDAVLP-GYTLKSQLDILSLLKQESPAPEPSIQHSYTYNVSNLDVRQ 4917

  Fly  1221 RKEGQDEVKREADPEEDEFAQRVAN----------METPATTPTPSP---------TQSNP---- 1262
            ......|   |..|.....|...|:          .|.||..|.|||         |:..|
  Rat  4918 LSAPPPE---EPSPPPSPLAPSPASPPAEPMVELQAEPPAEPPIPSPLPLASSPEATRPKPRARP 4979

  Fly  1263 ----EDSA------------STTTVLKELETGGGVRRSHR-----IKQ-----KP---------- 1291
                |||.            ....:|..::.|.|.:...|     ::|     :|
  Rat  4980 PDESEDSRPPRLKKWKGVRWKRLRLLLTIQKGSGRQEDEREVAEFMEQLGTALRPSKVPRDNRRC 5044

  Fly  1292 -----QGPRASQG----------------------------------------RGVAS------- 1304
                 :|..|:.|                                        ||:.:
  Rat  5045 CFCHEEGDGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQR 5109

  Fly  1305 --------------------------------VALAPI-----SMDEQLAELA----------NI 1322
                                            ..|.|:     ..:::|:..|          .:
  Rat  5110 TGATGSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKIKGPCEQELSSFAVFRRVYIERDEV 5174

  Fly  1323 EAINEQFLRSEGLNTF-----------QLLKENF------------------------------- 1345
            :.|.....|.|.|:.|           |||....
  Rat  5175 KQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLRTNNRRCC 5239

  Fly  1346 YRCARQVSQEN-----------------------------------AEMQCDC--------FLTG 1367
            |||:  :|:.|                                   |.|:.:.        :|.|
  Rat  5240 YRCS--ISENNGRPEFVIKVIEQGLEDLVFTDASPQAVWNRIIEPVAAMRKEADMLRLFPEYLKG 5302

  Fly  1368 D--------------EEAQGHLSC--------------------GAGC----------------- 1381
            :              |...|..||                    ..||
  Rat  5303 EELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSEPKILTHYKRVFTS 5367

  Fly  1382 ---------------INRMLMIECGPLCSNGARCT--NKRFQQHQCWPCRVFRTEKK-------- 1421
                           :|...|.:.......|...|  :|:|...:....|..|||.|
  Rat  5368 IISFDPHNNLMRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRTEWKNNVYLARS 5432

  Fly  1422 ---GCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGN 1483
               |.|:.|...:.....::||:|.:|.:|...||:.:| :::||..|...:..|.|||||..|.
  Rat  5433 RIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIY-EEQNRGIYMFRINNEHVIDATLTGG 5496

  Fly  1484 ISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQR--CYCEAANC 1546
            .:|||||||.||...:..|.:.|.:|...|.:.|..|||:|:|||: .:..|..:  |:|.|.||
  Rat  5497 PARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQF-DFEDDQHKIPCHCGAWNC 5560

  Fly  1547 RGWI 1550
            |.|:
  Rat  5561 RKWM 5564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	35/152 (23%)
		AWS	1358..1410	CDD:197795	15/127 (12%)
		SET_SETD2	1410..1551	CDD:380949	55/154 (36%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
Kmt2d	XP_063118908.1	None