DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Set2 and Setdb2

DIOPT Version :9

Sequence 1:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster
Sequence 2:	XP_038949803.1	Gene:	Setdb2 / 100361710	RGDID:	2319564	Length:	1008	Species:	Rattus norvegicus

Alignment Length:	1048	Identity:	193/1048 - (18%)
Similarity:	339/1048 - (32%)	Gaps:	312/1048 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1012 VKKKINPRRST---ICEAAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGS 1073
            :|:||....:|   ..:|...:..::.|::.|.| ...:|| |.::..:|.|....|:
  Rat    35 LKQKIKDGSATNGDYVQAMVLVNEATLSNSQTLE-KDHTPV-TQNEQKNKSNVFPSTS------- 90

  Fly  1074 KLDQRRYTICEDRQPETAIPVPLTKRRF-SMHPKASAN-----PLHDTLLQTAGKKRGRKEGKES 1132
                     ||:..||..|.:...::.| .::.|...:     |||.:...........:|...|
  Rat    91 ---------CENPSPEDCIILSTGRKGFLPVNNKTEGSGEKEPPLHASFHHHVCSSACLREAPLS 146

  Fly  1133 LSRQNSL---------------DSSSSA---SQGAPKKKALKSAEILSAALLETESSESTSSGSK 1179
            |..:|.|               :|.|:|   :...|..::|::.|.:...|||||.:...:
  Rat   147 LKGENPLQLPLRCHFQRRHAKTNSPSAALHVNYRTPCGRSLRNMEEVFHYLLETECNFLFT---- 207

  Fly  1180 MSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQDEVKREADPEEDEFAQRVA 1244
             ..:...|..:|...:|               |:::|..|.      ::....:.....|...|.
  Rat   208 -DNFSFNTYVQLTRNHP---------------KQNEVVSDV------DISNGVESVSISFCNEVD 250

  Fly  1245 NMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAP 1309
            |.:.|              .....|||                     .|||..
  Rat   251 NSKLP--------------QFKYRTTV---------------------WPRAYH----------- 269

  Fly  1310 ISMDEQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCA-RQVSQENAEMQCDCFLTGDEEAQG 1373
            :::....::..:.         |||....:       :|| .|::.:||:.   |.|:.|.|..|
  Rat   270 LNVSSMFSDSCDC---------SEGCIDIK-------KCACLQLTAKNAKA---CPLSPDGECTG 315

  Fly  1374 HLSCGAGCINRML---MIECGPLCS-NGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPG 1434
            :   ....:.|::   :.||...|. |...|.|:..|.......:||::||||.|:.....|..|
  Rat   316 Y---KYKRLQRLIPSGIYECNLFCKCNRQMCQNRVIQHGPRVRLQVFKSEKKGWGVRCLDDIDKG 377

  Fly  1435 EFIMEYVGEVI-------------DSEEFERRQHLYSK---------DRNRHYYFMALRG----- 1472
            .|:..|.|.::             :||:....::.:||         ||..|.......|
  Rat   378 TFVCIYSGRLLSRATPEKTNIGESESEQQHTVKNSFSKKRKIEVVCSDRQTHCESPKTEGCPPKF 442

  Fly  1473 -----EAVIDATSKGNISRYINHSC--DPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYL 1530
                 |.|::..:: ||||...||.  .|.::|..:..| |..:||.......|.|:..|.....
  Rat   443 SSDLEEPVVEMNNR-NISRTQRHSVIRRPKSKTDVFHYN-EKNMGFVCSYSAAPEEKNGFKPAQE 505

  Fly  1531 RYGRDAQRCYCEAANCRGWIGGEPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAK 1595
            .....|:|.:.:.::.:  :|    ..|.:||.|....|.....|  :..|..|....:......
  Rat   506 HLDSKARRAHEDLSSSQ--VG----YSEDKQLTESDVIDTTTSRE--DTSPAYGCKHAAILNSKN 562

  Fly  1596 SKLKAKLPLATGRKRKEQTKPKDREYKAGRWLKPSATGSSSSAEKPPKKPKVNKFQAMLEDPDVV 1660
            :|...::|:.|.:: :|....:.::...|..|          |.:..|.|..:..|
  Rat   563 TKKVLEVPVKTSQE-EEPAASQSQQVSCGEEL----------ASERTKIPSASLVQ--------- 607

  Fly  1661 EELSLLRRGGLKNQQDTLRFSRCLVRAKLLKTRLALL---------RVLTHGELP---CRRLFLD 1713
                                        |.|..|.||         |.|.|...|   .:.:|::
  Rat   608 ----------------------------LSKESLFLLDASKEGNVGRFLNHSCYPNLWVQNVFVE 644

  Fly  1714 YHGLRL-LHAWISENGNDDQLREALLDTLESLPIPNRTMLSDSRVYQSVQLWSNSLEQQLAVVPQ 1777
            .|.... |.|:.:..                 .:..||.|:....|::..:....:..|......
  Rat   645 THDRNFPLAAFFTNR-----------------YVKARTELTWDYGYEAGTMPEKEILCQCFCQVT 692

  Fly  1778 EKQAALHKRMVALLQKWQALPEIFRIPKRERIEQMKEHER---------EADRQQ-----KHVHA 1828
            ||   :.||...|..:......|:..|.    ..:..||.         |.:...     |:...
  Rat   693 EK---MEKRTCVLCPEGHDWSVIYFSPS----ANIAAHENCLLYSSGLVECEAHDPFNIAKNFDV 750

  Fly  1829 STALEDQRERESSNDRFRQDR---FRRDTTS---------SRIGKPIRMSGNNTICTI-----TT 1876
            |:.||......:|...|..:.   ...|.||         ::..:.|...|......|     ..
  Rat   751 SSVLEKIWNGSTSKCSFCNNEGAIMGCDETSCAKNYHLLCAKEDRAILQVGVKRTYKIFCPEHPP 815

  Fly  1877 QQKGSNGAPDGMT---RNDNRRRSDIGPPSEQRRTLSKELRR-----SLFERKVALDEAERRVCT 1933
            ||:.:....:|::   |...::|..:|||::.:....:..||     :|.:|..|:.....:.|.
  Rat   816 QQEETTERANGLSIKKRRGRKKRRSLGPPAQPKTMKCRRSRRHVTGEALGQRDAAVKAPFLKKCL 880

  Fly  1934 EDRLEHEL 1941
            |..|..||
  Rat   881 EAGLLTEL 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	13/55 (24%)
		SET	1414..1533	CDD:214614	37/152 (24%)
		PostSET	1535..1551	CDD:214703	2/15 (13%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Setdb2	XP_038949803.1	HMT_MBD	152..212	CDD:238689	12/64 (19%)
		SET	210..687	CDD:394802	112/640 (18%)
		SET	365..>425	CDD:395687	11/59 (19%)
		PHD_SF	700..813	CDD:419867	18/116 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351977
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930