DRSC/TRiP Functional Genomics Resources

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Protein Alignment Set2 and nsd1

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:XP_002936997.3 Gene:nsd1 / 100145675 XenbaseID:XB-GENE-989206 Length:2440 Species:Xenopus tropicalis


Alignment Length:2174 Identity:433/2174 - (19%)
Similarity:709/2174 - (32%) Gaps:783/2174 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   221 SCSDSDTNSTSTTTSNMSSDSGELPGFPIQKPKSKLRVSLKRLKLGGRLESSDSGNSPSSSSPEV 285
            ||:.:|:........            |::..|.:||:|        .:.:.||..:....|||.
 Frog   476 SCTKTDSKKQHRRLK------------PVKHRKVELRLS--------DVSTDDSRTTEEPGSPEF 520

  Fly   286 EPPALQDENAMDERPKQEQN-LSRMVDAEENSDSDSQIIFIEIETESPKGEEEQEEGRPVEVEPQ 349
            . .:...|:.....|.|::: :|:.:..|..:.|..:.:     |.|.|...:.:|         
 Frog   521 F-SSQTCESKFGMAPSQQESCISKQISKEVYNISQEKNV-----TLSAKKWNKNDE--------- 570

  Fly   350 DLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPGKEPAADS 414
             |::..:.|.:.:...|..::..|         ..|.....||::::....|..:...||.:|.:
 Frog   571 -LVEQSLGLERTKAQTDNGQEKSE---------KPLMGHKIEAKQKDFRLKQSVSSVQKERSAGT 625

  Fly   415 CSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHILIDLIEDTLSES 479
             :...:|.|..:.||.||::          :.|.|.......|.|.            |.:||:.
 Frog   626 -TKKRKRLRIHSELSRSSKR----------LVASSLDSSTNVESSN------------EFSLSKD 667

  Fly   480 EVTSSV-------------SPTIEHMVVEE-------VVVEENQLVDEADEILDSKQEFVIKKVF 524
            .||..|             ||::.::.:.:       .::|.|........|.|..     |.:.
 Frog   668 WVTEDVPDGNGHSVDKNKYSPSLTNVSLSDSCENLHNSLLESNAPSPSQHSIKDFP-----KALT 727

  Fly   525 SESDNIAA-------SLNKDIFEPKV---ETKATCGEVVPRPE---------------MVTEDVY 564
            .||.|...       |.:|:|.:.|:   ..||:.|: ..|||               |..|...
 Frog   728 PESKNCLVHDSATQNSQSKNILDSKLGHKPAKASLGK-TGRPEAMNLLSNMHEKSCDSMKNETKL 791

  Fly   565 ITEGIAATLEKS----------AVVTKPTTEMI-AETKLSDEVVIEPP---------LKDESDPK 609
            :...|:...|.|          :.|:||:|.:: |.....:.:.:||.         |||..|.|
 Frog   792 VNSVISGLKELSSRSLSEDGAESTVSKPSTPLLFASAPGQNRIPLEPDYKFSNLLMMLKDMHDTK 856

  Fly   610 QTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVE 674
                            ..||.|.....|.||...|.|    :|:.|                   
 Frog   857 ----------------TKERKLMTGQNTVSSCSDPCE----DSIKG------------------- 882

  Fly   675 TTPLKTEAAKEDSPPAAPE-----EEASNSSE-----EPNFLLEDYESNQEQVAEDEMMKCNNQK 729
                        ||...|:     ...::|:|     |||     .||......::::: ||.:.
 Frog   883 ------------SPDIVPDVGGISGNHTHSNEVGMVKEPN-----NESKLGATGQNKIV-CNRKS 929

  Fly   730 GQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKM 794
            ..|:....:.|.|.:|  :.|||.:|:|.:....:.:....::........|  ...|..|.|.:
 Frog   930 SSKKNSNFQKKPPMEP--KKVSKYKKSMISAQNVNASSECTELTTNSYNTSV--QLHGECPSKSI 990

  Fly   795 DSKKSCAAVTPAKQKESG-------------KSAKEAILKKETEKEK-----SSAKL--DSSSPN 839
            ....:|:.|.....:|:|             :|.|....||..:|.|     ||..|  .:|:.:
 Frog   991 THPYNCSEVGAGYPEETGPGSEQSSECSQWNESQKYVAPKKRWQKIKHNGPESSTNLLNKASTKS 1055

  Fly   840 TLDKKGKDTAQWSPQLQT------LPKSSTKPPQESAPSVISKTTSN--QPAPKEEQHAAKKGLS 896
            :|.||.:|..:...|||.      .|:.|:...|..||    |..||  :...|.::...:.|  
 Frog  1056 SLCKKEQDVLEVPKQLQDHEVTFGEPELSSIAAQPEAP----KRGSNFGKKYKKRKRFTRRSG-- 1114

  Fly   897 DN---SPPSVLKAKEKAVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPT 958
            |:   |.|.:.|.|:..||                  |:|:...:|.||.:...|:...::....
 Frog  1115 DHVKTSTPKINKQKKLGVS------------------LQLEVNKQKNLKLILPAVDFLSEINSKA 1161

  Fly   959 AVPVPGQKKSLSGKTSLRRNTVYEDSPNLERN---------------SSPSSDSAQANTSAGKLK 1008
            .......|.:.:..|..:.....|.|.:.|:.               |.|||.:||:..:  .::
 Frog  1162 TSSSQFSKLAEAYSTETKNPDNEEKSDSSEKEDHGLASPEQSLSDGFSEPSSITAQSQVN--PVR 1224

  Fly  1009 PSKVKKKINPRRSTICE---AAKDLRSSSSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLD 1070
            .::.|.|:.||   :||   ..:.|......|.|        |...:..:|.|:|..|::.    
 Frog  1225 ENRRKSKLIPR---VCEFDDLDEQLGLLEEDSKP--------PAKIAKTTSFKQNVLKQSF---- 1274

  Fly  1071 GGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPKASANPLHDTLLQTAGKKRGRKEGKESLSR 1135
                    ||.....|.||.      .:||              ..::.|||   .|:.:..:||
 Frog  1275 --------RYRAASRRLPEN------RRRR--------------KRIRLAGK---FKKKRNLISR 1308

  Fly  1136 QNS-----------LDSSSSASQGAPKKKALKSAEILSAALLETESSESTSSGSKMSR--WDVQT 1187
            |:|           ...|.:|.:|...:        |:.|.|:....|.:..|:.|..  ..|..
 Frog  1309 QSSYPGEEPHENGVASHSDTAEEGLEHE--------LTGASLKRNQGERSGGGAAMKENVCQVCE 1365

  Fly  1188 SP------ELEAANPFGDIAKFIEDGVNLLKRDKVDEDQ-------------------RKEGQDE 1227
            .|      |.:....|         .:..|..:.:.:.:                   .||....
 Frog  1366 KPGELLLCEAQCCGAF---------HLQCLGMEAMPQGKFVCTECSSGTLQGYHTCFVCKESDQG 1421

  Fly  1228 VKREADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRI----- 1287
            |||...|...::......::.|..      ||.|                 .|.|.|..|     
 Frog  1422 VKRCMLPLCGKYYHEECALKYPPA------TQQN-----------------RGFRCSLHICSTCY 1463

  Fly  1288 KQKPQGPRASQGR--------------------GVASVA----LAP------------------- 1309
            ...|..|.||:||                    |..::|    :.|                   
 Frog  1464 ATNPSNPSASKGRLMRCVRCPVAYHANDFCLPAGAVTLASNSIICPNHFTPRRGCKNHEHVNVSW 1528

  Fly  1310 --------------------------ISMDEQL-----------------------------AEL 1319
                                      |.|.|..                             ||:
 Frog  1529 CFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWFCNDCKAGKKPHYKEVVWVKVGRYRWWPAEV 1593

  Fly  1320 A-------NIEAINEQ------------------------FLRSEGLNTFQLLK----------- 1342
            .       ||:.:...                        ::..:.||..::.|           
 Frog  1594 CHPKTIPPNIQKMKHDIGEFPVVFFGSKDYLWTHQARVFPYMEGDALNKDKMSKGMDAVYKKGLM 1658

  Fly  1343 ---ENF-----YRCARQVSQE-------------------------NAEM----QCDCFLTGDEE 1370
               |.|     .:..||:.::                         .|::    :|:|..| ||.
 Frog  1659 EAAERFEELKAQKEMRQLQEDKKNDKKPPPYKHIKVNRPVGKVQILTADLSEIPRCNCKAT-DEN 1722

  Fly  1371 AQGHLSCG--AGCINRMLMIECGP-LCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIP 1432
                 .||  :.||||||:.||.| :|..|.||.|:.|.:.|.....:|||..:|.|:.....|.
 Frog  1723 -----PCGQDSECINRMLLYECHPSVCPAGERCQNQAFSKRQYPEVEIFRTLSRGWGLRCRTDIK 1782

  Fly  1433 PGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAE 1497
            .|||:.|||||:||.||...|.....:....::|.:.|..:.||||..|||.:|::||.|.||.|
 Frog  1783 KGEFVNEYVGEMIDEEECRARIRYAQEQDITNFYMLTLDKDRVIDAGPKGNFARFMNHCCQPNCE 1847

  Fly  1498 TQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEP------DS 1556
            ||||||||:.|:|.|::..|:.|.|:||:|.....|.....|.|.|.||.|::|..|      ..
 Frog  1848 TQKWTVNGDTRVGLFALCDIKAGVELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPVSSE 1912

  Fly  1557 DEGEQLDE-----ESDSDAEMDEE--------ELEAEPEEGQPR--------------------- 1587
            |:|::..:     :|:...|.::|        :|.:..:.|.|:                     
 Frog  1913 DKGKKRKQYVKRKKSEVVKEHEDECFSCGDGGQLVSCKKPGCPKVYHAECLKLTRRPAGKWECPW 1977

  Fly  1588 -------KSAKAKAK-----------------SKLKAKL-----------PLATGRKRKEQTKPK 1617
                   |.|.:..:                 |||..:|           ||..|..| |.....
 Frog  1978 HQCDICHKEAASLCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPHPLEPGEIR-EYDSSN 2041

  Fly  1618 DREYKAGRWLK-----PSATGSSSSAEKPPKKPKVNKFQAMLEDPDV----------------VE 1661
            ::...||..|.     .||.|.::|:....|...|.:   :|..|..                ||
 Frog  2042 EQNDSAGPSLPKKKTLDSAKGKTASSNSHKKNVSVTE---VLHTPTTAGSTSSGNVSKENVGSVE 2103

  Fly  1662 ELS------LLRRGGLKNQQDTLRFSRCLVRAKLLKTRLALLRVLTHGE----------LPCRRL 1710
            :.|      ||...|.|          |...:|||... |:.:.|..|:          ||..::
 Frog  2104 QKSLSAGKILLASAGQK----------CTTGSKLLLAS-AIQKSLPAGKVVLTSLGKKSLPAGKV 2157

  Fly  1711 FLDYHGLRLLHAW----ISENGNDDQLREALLDTL--ESLPIPNRTMLSDSRVYQS---VQLWSN 1766
            .|...|.:.|.|.    .|...|...:...::.|.  .||| ..:.:|:.:..|.:   |.|.|.
 Frog  2158 LLASIGKKQLSAGKVLVTSLGKNSPSVGRMIISTAGKHSLP-AGKVLLASAGKYTTAGKVLLTSA 2221

  Fly  1767 SLEQQLAVVPQEKQAALHKRMVALLQKWQALPEIFRIPKRERIEQMKEHEREADRQQKHVHASTA 1831
            :.:...|    ||.                        |.::...:||.:...|...||......
 Frog  2222 TNQHSTA----EKN------------------------KADKQNDVKETQNSLDPDTKHRITKKP 2258

  Fly  1832 LEDQRERESSNDRFRQDRFRRDTTSSRIGKPIRMSGNNTICTITTQQKGSN----GAPDGMTRND 1892
            | ::..::..|....|...:..||.  |.||:      :.|.:   ::.||    |.|: ..::.
 Frog  2259 L-NKPSKDKLNTTLEQPLTQNHTTG--IQKPV------SPCQV---ERPSNPSLTGRPE-KPKDK 2310

  Fly  1893 NRRRSDIGPPSEQRRTLSKELRRSLFERK 1921
            ::..|::.|....:|:.....||||...|
 Frog  2311 HQPDSEVHPKILLKRSTMPTSRRSLSAHK 2339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 22/58 (38%)
SET 1414..1533 CDD:214614 52/118 (44%)
PostSET 1535..1551 CDD:214703 6/15 (40%)
WW 2014..2043 CDD:278809
SRI 2270..2348 CDD:285448
nsd1XP_002936997.3 PWWP 316..421 CDD:413370
PHD1_NSD1_2 1360..1402 CDD:277118 5/50 (10%)
PHD2_NSD1 1411..1457 CDD:277120 13/68 (19%)
PHD3_NSD1 1458..1511 CDD:277123 10/52 (19%)
PHD4_NSD1 1528..1567 CDD:277126 3/38 (8%)
WHSC1_related 1573..1667 CDD:99899 9/93 (10%)
AWS 1720..1758 CDD:407759 19/42 (45%)
SET_NSD1 1760..1901 CDD:380987 59/140 (42%)
PHD5_NSD1 1936..1978 CDD:277129 4/41 (10%)
C5HCH 1977..2026 CDD:407828 6/48 (13%)
PTZ00449 <2209..>2434 CDD:185628 34/172 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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