Protein Alignment Set2 and nsd3

DIOPT Version :10

• Sequence 1: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Sequence 2: XP_694414.7
• Gene: nsd3 / 100006350
• ZFINID: ZDB-GENE-050324-2
• Length: 1563
• Species: Danio rerio
• Alignment Length: 1495
• Identity: 330/1495 - (22%)
• Similarity: 537/1495 - (35%)
• Gaps: 477/1495 - (31%)

  Fly   365 PDPEEDLDEIMVEVLSGPPS-LWSADDEAEEEEDATVQRATPPGKEPAADSCSSAPRRSRRSAP- 427
            |.|...|   |.:||..||. |..:.......:::|:  :.|.| :|.....::.|:::  |:|
Zfish   172 PPPASHL---MPQVLPPPPPLLLPSSPPLLSPQESTI--SNPIG-QPVNTIITTTPKKT--SSPE 228

  Fly   428 --------------LSGSSRQGKTLEETFAEIAAESSKQILE----------------AEESQD- 461
                          |..||..|..|:| |.  |.|.|::..|                .||||.
Zfish   229 IKLKIIKTYQNGRELFESSLCGDLLQE-FQ--AGEDSRRQHEQKKEKRKKRGSRHGAGQEESQQP 290

  Fly   462 ---QEEQHILIDLIEDTLSESEV---------TSSVSPTIEHMVVEEVVVEENQLVDEADEILDS 514
               :||:.:::.....| :||:|         :|..||..|        ::|.::......::.|
Zfish   291 SKVEEERSVVVHNPVQT-TESQVAFREEQQPQSSLKSPKAE--------LKEQKVEKHCPSVITS 346

  Fly   515 ---KQEFVIKKVFSESDNIAASLNKDIFEP-------------KVETKATCGEV-------VPRP 556
               .||:.|      .|.:.|.:....:.|             ::.|:. |.|.       ||..
Zfish   347 TGTSQEYEI------GDLVWAKVGTYPWWPCMVSSDPQSNVHTRINTRG-CKEYHVQFFGSVPER 404

  Fly   557 EMVTED---VYITEG-----IAATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDESDPKQTEV 613
            ..:.|.   ||.:|.     .|.||.||   |.||.:         :.:::|  :.:.:..|.||
Zfish   405 AWIHEKRTVVYKSENQFDELQAETLRKS---TNPTEK---------QKLLKP--QSQKERAQWEV 455

  Fly   614 ELPESKPAVNIPKSERILS-----------AEVETTSSPLVPPE---CCTLESVSGPVLLETSLS 664
            .:..::.|:.:.:.||..:           |:.||.::|...|:   ....::|:.|      .:
Zfish   456 GVGHAEAALQMTREERNENYTFIYIDKEPGADAETAAAPAPAPDSAPTAPTDTVTSP------KA 514

  Fly   665 TEEKSNENVETTPLKTEAAKEDSPP--AAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNN 727
            |.:...|..:.....:..|||:..|  ..|..:.|.:|     :.|....||.:.|.::...|:.
Zfish   515 TAKNRPERKQRRSRGSAGAKEEPIPRRQQPRRQCSMNS-----VGETSSPNQGEDAMEQEQPCSP 574

  Fly   728 QKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPA--IVDKKVRAGEMEKKVVKSTKGTVP 790
            .|     |.|..|||..|...|          |.|::.|  ::...:...::..:::| ....:|
Zfish   575 PK-----PAPRPKEPSPPPVRT----------PWRTAAARKLLPLSITMKKLNVEIIK-CDWQLP 623

  Fly   791 EKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQL 855
            ::|::..|.    |.::::.|         .:....|.||.|.::.:.::.:::....:.||.|.
Zfish   624 KQKVELPKK----TESEERPS---------SRVKSPEGSSNKAEAETCSSEEERAASPSGWSDQE 675

  Fly   856 QTLPKSSTKPPQESAPSVISKTTSN---QPAPKEEQHAAKKGLSDNSPPSVLK-AKEKAVSGFVE 916
            .|..:.||:..|:.. ||.|::.|.   :|.||::   .||..::.:|....| ..:|..|...:
Zfish   676 HTSAEQSTERKQQRR-SVRSRSESEKSVEPVPKKK---VKKEQAETAPQMDFKTGSQKGASEISD 736

  Fly   917 -CDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTV 980
             |                  |..||..:..|.||.                     .:||.|:|.
Zfish   737 SC------------------KPLKKRSRASTDVEM---------------------ASSLYRDTS 762

  Fly   981 YEDSPNL--------ERNSSPS------SDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDL- 1030
            ..||..|        :|:.||:      ||:...::|..:...|..||      .|:|...:..
Zfish   763 DSDSRGLNDPQTGFGKRSDSPATVDADGSDAQSVDSSLSRQGGSSSKK------DTVCHVCETFG 821

  Fly  1031 ---------------------RSSSSSSTPTREVAASSPVSTS---SDSSSKR---NGSKR---- 1064
                                 .|...|.|..:|....|....|   ::...||   ||..|
Zfish   822 DSLVSCEGDCNRLFHPECMGSNSGKESETVCQECKTGSHPCFSCKVTEGDMKRCSVNGCGRYYHE 886

  Fly  1065 --------TTSDLDGGSKLDQRRYTICEDRQPETA--------IPVPLTKRR------------- 1100
                    :.||..|.........|.|.||..:.|        |..|:....
Zfish   887 TCVRKYTGSASDTKGLRCPQHSCATCCLDRDLQKAGKGRMMRCIRCPVAYHTGDGCVAAGSVLIT 951

  Fly  1101 -----FSMHPKASAN-----PLH-----------------DTLLQTAGKKRG---RKEGKESLSR 1135
                 .|.|..:..|     |::                 ||:|.:...|..   .:..:..|.:
Zfish   952 PHIIICSNHSSSRKNGHFSSPVNVGWCFICARGLLVHDHTDTILSSYTFKSHYLLTESNRAELMK 1016

  Fly  1136 QNSLDSSSSASQGAPKKKALKSAEILSA---------ALLETESSEST------SSGSKMS---- 1181
            ...:.|||||:    ||...|...:|..         ..|:.|..|.|      .||.|..
Zfish  1017 LPMIPSSSSAT----KKNIGKGGRLLCCEACPASFHPECLKIEMPEGTWLCGECKSGKKPHYKQI 1077

  Fly  1182 --------RWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVD--------EDQRKEGQDEVKR 1230
                    ||     ...|..||     :.:...:..||.|..|        .|.....|..|..
Zfish  1078 VWVKLGNYRW-----WPAEICNP-----RLVPSNIQSLKHDIGDFPVFFFGSHDYYWINQGRVFP 1132

  Fly  1231 EADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPR 1295
            ..:.::: ||:....:                     ..|..|.||.  ..:|...:|
Zfish  1133 YVESDKN-FAEGQVGI---------------------NKTFKKALEE--AAKRFQELK------- 1166

  Fly  1296 ASQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKEN--FYRCARQVSQENAE 1358
                                 |:....||: ||...|.....::|:|.|  |.:....|:..:..
Zfish  1167 ---------------------AQRETKEAL-EQERNSRRPPPYKLIKSNKPFGKVQLHVADLSEI 1209

  Fly  1359 MQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGP-LCSNGARCTNKRFQQHQCWPCRVFRTEKKG 1422
            .:|:|..|.:...    |..:.|:||||..||.| :|..|.||.|:.|.:.......|.:|..:|
Zfish  1210 PRCNCKPTDERPC----SQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSKRLYPDTEVIKTTGRG 1270

  Fly  1423 CGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRY 1487
            .|:..:..:..|:|:||||||:|||||.::|....:::...::|.:.|..:.||||..|||:||:
Zfish  1271 WGLKTKQDLKKGDFVMEYVGELIDSEECKQRIRTANENHVTNFYMLTLTKDRVIDAGPKGNLSRF 1335

  Fly  1488 INHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGG 1552
            :||||.||.|||||||||::|||.|::..|....|:||:|.....|.....|:|.:.||.|::|.
Zfish  1336 MNHSCSPNCETQKWTVNGDVRIGLFTLCDISADTELTFNYNLDCLGNGRTSCHCGSENCSGFLGV 1400

  Fly  1553 EPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKRKEQTKPK 1617
            :|            .|...|:.||           |...||.|.|           |||.:|:.|
Zfish  1401 KP------------KSAVVMEREE-----------KVRNAKLKPK-----------KRKLKTESK 1431

  Fly  1618  1617
            Zfish  1432  1431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Set2	NP_572888.2	valS	<709..832	CDD:237855	24/124 (19%)
		AWS	1358..1410	CDD:197795	18/52 (35%)
		SET_SETD2	1410..1551	CDD:380949	59/140 (42%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404
nsd3	XP_694414.7	None