DRSC/TRiP Functional Genomics Resources

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Protein Alignment Set2 and nsd3

DIOPT Version :9

Sequence 1:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster
Sequence 2:XP_005155379.1 Gene:nsd3 / 100006350 ZFINID:ZDB-GENE-050324-2 Length:1563 Species:Danio rerio


Alignment Length:1495 Identity:330/1495 - (22%)
Similarity:537/1495 - (35%) Gaps:477/1495 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   365 PDPEEDLDEIMVEVLSGPPS-LWSADDEAEEEEDATVQRATPPGKEPAADSCSSAPRRSRRSAP- 427
            |.|...|   |.:||..||. |..:.......:::|:  :.|.| :|.....::.|:::  |:| 
Zfish   172 PPPASHL---MPQVLPPPPPLLLPSSPPLLSPQESTI--SNPIG-QPVNTIITTTPKKT--SSPE 228

  Fly   428 --------------LSGSSRQGKTLEETFAEIAAESSKQILEA----------------EESQD- 461
                          |..||..|..|:| |.  |.|.|::..|.                ||||. 
Zfish   229 IKLKIIKTYQNGRELFESSLCGDLLQE-FQ--AGEDSRRQHEQKKEKRKKRGSRHGAGHEESQQP 290

  Fly   462 ---QEEQHILIDLIEDTLSESEV---------TSSVSPTIEHMVVEEVVVEENQLVDEADEILDS 514
               :||:.:::.....| :||:|         :|..||..|        ::|.::......::.|
Zfish   291 SKVEEERSVVVHNPVQT-TESQVAFREEQQPQSSLKSPKAE--------LKEQKVEKHCPSVITS 346

  Fly   515 ---KQEFVIKKVFSESDNIAASLNKDIFEP-------------KVETKATCGEV-------VPRP 556
               .||:.|      .|.:.|.:....:.|             ::.|:. |.|.       ||..
Zfish   347 TGTSQEYEI------GDLVWAKVGTYPWWPCMVSSDPQSNVHTRINTRG-CKEYHVQFFGSVPER 404

  Fly   557 EMVTED---VYITEG-----IAATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDESDPKQTEV 613
            ..:.|.   ||.:|.     .|.||.||   |.||.:         :.:::|  :.:.:..|.||
Zfish   405 AWIHEKRTVVYKSENQFDELQAETLRKS---TNPTEK---------QKLLKP--QSQKERAQWEV 455

  Fly   614 ELPESKPAVNIPKSERILS-----------AEVETTSSPLVPPE---CCTLESVSGPVLLETSLS 664
            .:..::.|:.:.:.||..:           |:.||.::|...|:   ....::|:.|      .:
Zfish   456 GVGHAEAALQMTREERNENYTFIYIDKEPGADAETAAAPAPAPDSAPTAPTDTVTSP------KA 514

  Fly   665 TEEKSNENVETTPLKTEAAKEDSPP--AAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKCNN 727
            |.:...|..:.....:..|||:..|  ..|..:.|.:|     :.|....||.:.|.::...|:.
Zfish   515 TAKNRPERKQRRSRGSAGAKEEPIPRRQQPRRQCSMNS-----VGETSSPNQGEDAMEQEQPCSP 574

  Fly   728 QKGQKQTPLPEMKEPEKPVAETVSKKEKAMENPARSSPA--IVDKKVRAGEMEKKVVKSTKGTVP 790
            .|     |.|..|||..|...|          |.|::.|  ::...:...::..:::| ....:|
Zfish   575 PK-----PAPRPKEPSPPPVRT----------PWRTAAARKLLPLSITMKKLNVEIIK-CDWQLP 623

  Fly   791 EKKMDSKKSCAAVTPAKQKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDKKGKDTAQWSPQL 855
            ::|::..|.    |.::::.|         .:....|.||.|.::.:.::.:::....:.||.|.
Zfish   624 KQKVELPKK----TESEERPS---------SRVKSPEGSSNKAEAETCSSEEERAASPSGWSDQE 675

  Fly   856 QTLPKSSTKPPQESAPSVISKTTSN---QPAPKEEQHAAKKGLSDNSPPSVLK-AKEKAVSGFVE 916
            .|..:.||:..|:.. ||.|::.|.   :|.||::   .||..::.:|....| ..:|..|...:
Zfish   676 HTSAEQSTERKQQRR-SVRSRSESEKSVEPVPKKK---VKKEQAETAPQMDFKTGSQKGASEISD 736

  Fly   917 -CDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQKKSLSGKTSLRRNTV 980
             |                  |..||..:..|.||.                     .:||.|:|.
Zfish   737 SC------------------KPLKKRSRASTDVEM---------------------ASSLYRDTS 762

  Fly   981 YEDSPNL--------ERNSSPS------SDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDL- 1030
            ..||..|        :|:.||:      ||:...::|..:...|..||      .|:|...:.. 
Zfish   763 DSDSRGLNDPQTGFGKRSDSPATVDADGSDAQSVDSSLSRQGGSSSKK------DTVCHVCETFG 821

  Fly  1031 ---------------------RSSSSSSTPTREVAASSPVSTS---SDSSSKR---NGSKR---- 1064
                                 .|...|.|..:|....|....|   ::...||   ||..|    
Zfish   822 DSLVSCEGDCNRLFHPECMGSNSGKESETVCQECKTGSHPCFSCKVTEGDMKRCSVNGCGRYYHE 886

  Fly  1065 --------TTSDLDGGSKLDQRRYTICEDRQPETA--------IPVPLTKRR------------- 1100
                    :.||..|.........|.|.||..:.|        |..|:....             
Zfish   887 TCVRKYTGSASDTKGLRCPQHSCATCCLDRDLQKAGKGRMMRCIRCPVAYHTGDGCVAAGSVLIT 951

  Fly  1101 -----FSMHPKASAN-----PLH-----------------DTLLQTAGKKRG---RKEGKESLSR 1135
                 .|.|..:..|     |::                 ||:|.:...|..   .:..:..|.:
Zfish   952 PHIIICSNHSSSRKNGHFSSPVNVGWCFICARGLLVHDHTDTILSSYTFKSHYLLTESNRAELMK 1016

  Fly  1136 QNSLDSSSSASQGAPKKKALKSAEILSA---------ALLETESSEST------SSGSKMS---- 1181
            ...:.|||||:    ||...|...:|..         ..|:.|..|.|      .||.|..    
Zfish  1017 LPMIPSSSSAT----KKNIGKGGRLLCCEACPASFHPECLKIEMPEGTWLCGECKSGKKPHYKQI 1077

  Fly  1182 --------RWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVD--------EDQRKEGQDEVKR 1230
                    ||     ...|..||     :.:...:..||.|..|        .|.....|..|..
Zfish  1078 VWVKLGNYRW-----WPAEICNP-----RLVPSNIQSLKHDIGDFPVFFFGSHDYYWINQGRVFP 1132

  Fly  1231 EADPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGPR 1295
            ..:.::: ||:....:                     ..|..|.||.  ..:|...:|       
Zfish  1133 YVESDKN-FAEGQVGI---------------------NKTFKKALEE--AAKRFQELK------- 1166

  Fly  1296 ASQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEGLNTFQLLKEN--FYRCARQVSQENAE 1358
                                 |:....||: ||...|.....::|:|.|  |.:....|:..:..
Zfish  1167 ---------------------AQRETKEAL-EQERNSRRPPPYKLIKSNKPFGKVQLHVADLSEI 1209

  Fly  1359 MQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGP-LCSNGARCTNKRFQQHQCWPCRVFRTEKKG 1422
            .:|:|..|.:...    |..:.|:||||..||.| :|..|.||.|:.|.:.......|.:|..:|
Zfish  1210 PRCNCKPTDERPC----SQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSKRLYPDTEVIKTTGRG 1270

  Fly  1423 CGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRY 1487
            .|:..:..:..|:|:||||||:|||||.::|....:::...::|.:.|..:.||||..|||:||:
Zfish  1271 WGLKTKQDLKKGDFVMEYVGELIDSEECKQRIRTANENHVTNFYMLTLTKDRVIDAGPKGNLSRF 1335

  Fly  1488 INHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGG 1552
            :||||.||.|||||||||::|||.|::..|....|:||:|.....|.....|:|.:.||.|::|.
Zfish  1336 MNHSCSPNCETQKWTVNGDVRIGLFTLCDISADTELTFNYNLDCLGNGRTSCHCGSENCSGFLGV 1400

  Fly  1553 EPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKAKSKLKAKLPLATGRKRKEQTKPK 1617
            :|            .|...|:.||           |...||.|.|           |||.:|:.|
Zfish  1401 KP------------KSAVVMEREE-----------KVRNAKLKPK-----------KRKLKTESK 1431

  Fly  1618  1617
            Zfish  1432  1431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Set2NP_572888.2 AWS 1358..1410 CDD:197795 18/52 (35%)
SET 1414..1533 CDD:214614 53/118 (45%)
PostSET 1535..1551 CDD:214703 5/15 (33%)
WW 2014..2043 CDD:278809
SRI 2270..2348 CDD:285448
nsd3XP_005155379.1 PWWP 351..468 CDD:321985 28/137 (20%)
PHD1_NSD3 813..856 CDD:277119 5/42 (12%)
PHD_SF 861..907 CDD:328929 9/45 (20%)
PHD3_NSD3 908..960 CDD:277125 8/51 (16%)
PHD4_NSD3 1033..1066 CDD:277128 6/32 (19%)
WHSC1_related 1072..1165 CDD:99899 19/126 (15%)
AWS 1208..1258 CDD:197795 18/53 (34%)
SET 1259..1382 CDD:214614 53/122 (43%)
PHD5_NSD3 1437..1479 CDD:277131
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593897
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D507784at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.880

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