DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG1998 and FA2H

DIOPT Version :9

Sequence 1:NP_001285210.1 Gene:CG1998 / 32300 FlyBaseID:FBgn0030485 Length:406 Species:Drosophila melanogaster
Sequence 2:NP_077282.3 Gene:FA2H / 79152 HGNCID:21197 Length:372 Species:Homo sapiens


Alignment Length:275 Identity:57/275 - (20%)
Similarity:94/275 - (34%) Gaps:92/275 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   139 WDKFIDSFGDEPMVLWVFGTTIFTMLVYWTVGTLYTFMDLTNRPACLRKYKIQPGTNEPVE---- 199
            |||        .:|.|       ...:.|.||.|....|         ::..||.| .|:.    
Human   119 WDK--------DLVDW-------RKPLLWQVGHLGEKYD---------EWVHQPVT-RPIRLFHS 158

  Fly   200 --VRRLLKVIWCVVCNQIFVGIPLA-YASYRLMEIRGLSDIRDLPTFHWVCFELTVCI------- 254
              :..|.|.:|..|   ..:.:||. |.|:.........::|...:|   ..|.||.:       
Human   159 DLIEGLSKTVWYSV---PIIWVPLVLYLSWSYYRTFAQGNVRLFTSF---TTEYTVAVPKSMFPG 217

  Fly   255 ----------LMEELGFYYSHRLLHHKH----------IYKYIHKQHHEWTAPISVTAIYCHPIE 299
                      |:|    |..||.|.|..          ::..:|.|||:  ||...:.:...|:.
Human   218 LFMLGTFLWSLIE----YLIHRFLFHMKPPSDSYYLIMLHFVMHGQHHK--APFDGSRLVFPPVP 276

  Fly   300 HIFSNLLPPFLGVFLMGSHV----ATAWLWFALAILSTLNAHSGYHLPFFPSPEAHDF------H 354
               ::|:   :|||.:...:    |.....||..:|..:.....::...|.||....:      |
Human   277 ---ASLV---IGVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAH 335

  Fly   355 HLKFN-----NCFGV 364
            |:|.:     :.||:
Human   336 HVKHHFAHQKSGFGI 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1998NP_001285210.1 ERG3 <245..374 CDD:225546 33/162 (20%)
FA_hydroxylase 250..374 CDD:282034 32/157 (20%)
FA2HNP_077282.3 Cyt-b5 15..85 CDD:278597
FA_hydroxylase 124..366 CDD:294712 54/262 (21%)
ERG3 <210..367 CDD:225546 30/153 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3000
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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