DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1998 and SC5D

DIOPT Version :9

Sequence 1:	NP_001285210.1	Gene:	CG1998 / 32300	FlyBaseID:	FBgn0030485	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_001020127.1	Gene:	SC5D / 6309	HGNCID:	10547	Length:	299	Species:	Homo sapiens

Alignment Length:	243	Identity:	68/243 - (27%)
Similarity:	105/243 - (43%)	Gaps:	36/243 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 TTIFTMLVYWTVGTL-YTFM---DLTNRPACLRKYKIQPGTNEPVEVRRLLKVIWCVVCNQIFVG 218
            |.:...::|:...|| |.|:   .|...|..|:.           :|||.:|     ...|....
Human    38 TNVGAYILYFFCATLSYYFVFDHALMKHPQFLKN-----------QVRREIK-----FTVQALPW 86

  Fly   219 IPLAYASYRLMEIRGLSDIR-DLPTFHWVCFELTVCIL----MEELGFYYSHRLLHHKHIYKYIH 278
            |.:...:..|:||||.|.:. ||..|.:..|||.|.|:    ..::..|:.||.|||:.:||.:|
Human    87 ISILTVALFLLEIRGYSKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLH 151

  Fly   279 KQHHEWTAPISVTAIYCHPIEHIFSNLLPPFLGVFLMGSHVATAWLWFALAILSTLNAHSG-YHL 342
            |.||.|..|....:...|||:. |...||..:..|:...|.......:.|..:.|::.|.| :.:
Human   152 KPHHIWKIPTPFASHAFHPIDG-FLQSLPYHIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRV 215

  Fly   343 -----PFFPSPEAHDFHHLKFNNCFGVLGVL-DRLHGTDSLFRATKSY 384
                 ||......|..||:.|:..:|....| ||:.|:   |:...|:
Human   216 PQILQPFINGSAHHTDHHMFFDYNYGQYFTLWDRIGGS---FKNPSSF 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1998	NP_001285210.1	ERG3	<245..374	CDD:225546	41/139 (29%)
CG1998	NP_001285210.1	FA_hydroxylase	250..374	CDD:282034	39/134 (29%)
SC5D	NP_001020127.1	ERG3	34..257	CDD:225546	67/238 (28%)
		Histidine box-1	138..143		3/4 (75%)
		Histidine box-2	151..155		2/3 (67%)
		Histidine box-3	228..233		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..299
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3000
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810