DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1998 and FAXDC2

DIOPT Version :9

Sequence 1:	NP_001285210.1	Gene:	CG1998 / 32300	FlyBaseID:	FBgn0030485	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_115761.2	Gene:	FAXDC2 / 10826	HGNCID:	1334	Length:	333	Species:	Homo sapiens

Alignment Length:	323	Identity:	150/323 - (46%)
Similarity:	209/323 - (64%)	Gaps:	1/323 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 GSPLQNWDDARTADVWLSSLHSVIFIITCALAAFILFRNVLTWHLQSFWGASGDFWQSQWDKFID 144
            |..|.|....:...:| .|:....||:...|.:|:.|.|.:|||||.||||||.|||:||::.:.
Human     6 GHMLHNEKSKQEGHIW-GSMRRTAFILGSGLLSFVAFWNSVTWHLQRFWGASGYFWQAQWERLLT 69

  Fly   145 SFGDEPMVLWVFGTTIFTMLVYWTVGTLYTFMDLTNRPACLRKYKIQPGTNEPVEVRRLLKVIWC 209
            :|..:..:|:..|......|.:|:...|...:|.|.:|..:.:|:||.|.||||:..:|.:.|..
Human    70 TFEGKEWILFFIGAIQVPCLFFWSFNGLLLVVDTTGKPNFISRYRIQVGKNEPVDPVKLRQSIRT 134

  Fly   210 VVCNQIFVGIPLAYASYRLMEIRGLSDIRDLPTFHWVCFELTVCILMEELGFYYSHRLLHHKHIY 274
            |:.||..:..|:....|..::.......|:||||||...||.:..|:||:.||||||||||...|
Human   135 VLFNQCMISFPMVVFLYPFLKWWRDPCRRELPTFHWFLLELAIFTLIEEVLFYYSHRLLHHPTFY 199

  Fly   275 KYIHKQHHEWTAPISVTAIYCHPIEHIFSNLLPPFLGVFLMGSHVATAWLWFALAILSTLNAHSG 339
            |.|||:||||||||.|.::|.|||||..||:||..:|..:||||:::..:||:||::.|..:|.|
Human   200 KKIHKKHHEWTAPIGVISLYAHPIEHAVSNMLPVIVGPLVMGSHLSSITMWFSLALIITTISHCG 264

  Fly   340 YHLPFFPSPEAHDFHHLKFNNCFGVLGVLDRLHGTDSLFRATKSYARHIMMLSFKPPRDAFPD 402
            |||||.||||.||:||||||.|:|||||||.|||||::|:.||:|.||:::|.|.|..::.||
Human   265 YHLPFLPSPEFHDYHHLKFNQCYGVLGVLDHLHGTDTMFKQTKAYERHVLLLGFTPLSESIPD 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1998	NP_001285210.1	ERG3	<245..374	CDD:225546	79/128 (62%)
CG1998	NP_001285210.1	FA_hydroxylase	250..374	CDD:282034	77/123 (63%)
FAXDC2	NP_115761.2	FA_hydroxylase	175..299	CDD:309300	77/123 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146981
Domainoid	1	1.000	183	1.000	Domainoid score	I3445
eggNOG	1	0.900	-	-		E1_COG3000
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41863
Inparanoid	1	1.050	331	1.000	Inparanoid score	I2446
Isobase	1	0.950	-	0	Normalized mean entropy	S2297
OMA	1	1.010	-	-		QHG48620
OrthoDB	1	1.010	-	-		D1321777at2759
OrthoFinder	1	1.000	-	-		FOG0002076
OrthoInspector	1	1.000	-	-		oto89402
orthoMCL	1	0.900	-	-		OOG6_105513
Panther	1	1.100	-	-	LDO	PTHR11863
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R751
SonicParanoid	1	1.000	-	-		X3944
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750