DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GstT4 and MARS1

DIOPT Version :9

Sequence 1:	NP_572886.2	Gene:	GstT4 / 32299	FlyBaseID:	FBgn0030484	Length:	237	Species:	Drosophila melanogaster
Sequence 2:	NP_004981.2	Gene:	MARS1 / 4141	HGNCID:	6898	Length:	900	Species:	Homo sapiens

Alignment Length:	158	Identity:	39/158 - (24%)
Similarity:	57/158 - (36%)	Gaps:	44/158 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SRALYILLEASKIPFEAIPISMLKGEHLTGEFR------DNVNRFRKLPAITDHGYQLSENV--- 71
            |.|||.|:...|           |||.:.|..|      |:....:..|.:......|::.|
Human    97 SAALYYLVVQGK-----------KGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWG 150

  Fly    72 AIFRHLAREKLVPEH------WYPRRHLGRSRIDEYLAWQQTNMGVATTEYFQQKWLV--PYLQK 128
            |::..|.....:||.      |:           :.|:.|:.....|.|...||..|.  |||||
Human   151 ALYPLLQDPAYLPEELSALHSWF-----------QTLSTQEPCQRAAETVLKQQGVLALRPYLQK 204

  Fly   129 ---TRPADN--AVNLASKQLEHTLNEFE 151
               ..||:.  ..|...::...||:|.|
Human   205 QPQPSPAEGRAVTNEPEEEELATLSEEE 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstT4	NP_572886.2	GST_N_Theta	5..80	CDD:239348	17/72 (24%)
GstT4	NP_572886.2	GST_C_Theta	95..220	CDD:198292	19/64 (30%)
MARS1	NP_004981.2	Thioredoxin_like	<27..68	CDD:294274
		GstA	<47..189	CDD:223698	23/113 (20%)
		GST_C_MetRS_N	77..179	CDD:198340	21/103 (20%)
		PRK12268	264..819	CDD:237029
		MetRS_core	265..633	CDD:173907
		'HIGH' region	273..283
		'KMSKS' region	593..597
		Anticodon_Ia_Met	642..771	CDD:153411
		MetRS_RNA	845..889	CDD:238475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900