DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1673 and BCAT2

DIOPT Version :9

Sequence 1:	NP_572884.1	Gene:	CG1673 / 32297	FlyBaseID:	FBgn0030482	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001181.2	Gene:	BCAT2 / 587	HGNCID:	977	Length:	392	Species:	Homo sapiens

Alignment Length:	361	Identity:	181/361 - (50%)
Similarity:	254/361 - (70%)	Gaps:	4/361 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 FRASQISVRLAAPEQLQPKPDNDEELGFGRLFTDHMLKIYYHKSLGGWQRPEITPLENLVMHPAA 142
            |:|:.:.:.:.  ::...||...|.|.||:.||||||.:.::..  ||.:|.|.|.:||.:|||:
Human    32 FKAADLQLEMT--QKPHKKPGPGEPLVFGKTFTDHMLMVEWNDK--GWGQPRIQPFQNLTLHPAS 92

  Fly   143 KVLHYAVELFEGMKAYRGVDGKIRIFRPDMNMNRMNLAAQRSGLPTFEGKEFVQCLSRLLSIDSE 207
            ..|||:::|||||||::|.|.::|:|||.:||:||..:|.|..||:|:..|.::|:.||:.:|.:
Human    93 SSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKD 157

  Fly   208 WVPHTDTASLYIRPTLIGIDPTLGVASSDSALLYTILSPVGSYFKTGSSGAVSLLADPSYVRAWP 272
            |||.....|||:||.|||.:|:|||:....|||:.||.|||:||..||...|||||||:::|||.
Human   158 WVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWV 222

  Fly   273 GGVGNRKMGSNYAPTINVQKEAAAKGLQQVLWLYGEDHQLTEVGTMNIFMFFVNDQGEQELVTPP 337
            |||||.|:|.||.||:.||:||..:|.:|||||||.|||||||||||||:::.::.|..||||||
Human   223 GGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPP 287

  Fly   338 LSGLILPGITRDSILRMTRQWGKFKVSEANITMPMVCELLNQGRLLELFGAGTACVVSPVNRISY 402
            |:|:||||:.|.|:|.|.:.||:|:|.|..|||..:...|.:||:.|:||:||||.|.||:||.|
Human   288 LNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILY 352

  Fly   403 LGQDLYIPTMEQEKPVHELIRETLTDIQYGRVDHPW 438
            ..::|:|||||....:....::.|.:||||...|.|
Human   353 KDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEW 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1673	NP_572884.1	PRK13357	82..443	CDD:237363	179/357 (50%)
CG1673	NP_572884.1	BCAT_beta_family	138..432	CDD:238798	156/293 (53%)
BCAT2	NP_001181.2	BCAT_beta_family	87..382	CDD:238798	156/294 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159262
Domainoid	1	1.000	305	1.000	Domainoid score	I1368
eggNOG	1	0.900	-	-		E1_COG0115
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	400	1.000	Inparanoid score	I1942
Isobase	1	0.950	-	0	Normalized mean entropy	S737
OMA	1	1.010	-	-		QHG53536
OrthoDB	1	1.010	-	-		D280685at33208
OrthoFinder	1	1.000	-	-		FOG0000948
OrthoInspector	1	1.000	-	-		otm41840
orthoMCL	1	0.900	-	-		OOG6_100313
Panther	1	1.100	-	-	O	PTHR11825
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R129
SonicParanoid	1	1.000	-	-		X560
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750