DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1662 and MPV17L2

DIOPT Version :9

Sequence 1:	NP_001285209.1	Gene:	CG1662 / 32296	FlyBaseID:	FBgn0030481	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_116072.2	Gene:	MPV17L2 / 84769	HGNCID:	28177	Length:	206	Species:	Homo sapiens

Alignment Length:	189	Identity:	71/189 - (37%)
Similarity:	105/189 - (55%)	Gaps:	13/189 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GFGALQKLREWHASAFSSRFLLFTNVGISLTLSC-----VGDVLEQHLEIYCGEIERFESTRTAH 114
            |:..|::|.......|..|.||.||     ||.|     .||.:.|..||.....:.|:..|:|.
Human     5 GWRRLRRLLSAGQLLFQGRALLVTN-----TLGCGALMAAGDGVRQSWEIRARPGQVFDPRRSAS 64

  Fly   115 MAISGVTVGVICHYWYKMLDKRMPGRTMR---VVAKKIVLDQLICSPIYISAFFVTLGLLEQKTK 176
            |...|.::|...||||..||:..|...:|   .|.||:::|||:.||:....:|:.||.||.:|.
Human    65 MFAVGCSMGPFLHYWYLSLDRLFPASGLRGFPNVLKKVLVDQLVASPLLGVWYFLGLGCLEGQTV 129

  Fly   177 HEVWEEIKEKAWKLYAAEWTVWPVAQFVNFYWIPTHYRIFYDNIISLGYDVLTSKVKHK 235
            .|..:|::||.|:.|.|:|.|||.||||||.::|..:|:.|.|.::||:|...|.:|::
Human   130 GESCQELREKFWEFYKADWCVWPAAQFVNFLFVPPQFRVTYINGLTLGWDTYLSYLKYR 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1662	NP_001285209.1	Mpv17_PMP22	170..234	CDD:282035	28/63 (44%)
MPV17L2	NP_116072.2	Mpv17_PMP22	122..183	CDD:397992	28/60 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147002
Domainoid	1	1.000	69	1.000	Domainoid score	I9646
eggNOG	1	0.900	-	-		E1_KOG1944
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13093
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1324608at2759
OrthoFinder	1	1.000	-	-		FOG0003674
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100380
Panther	1	1.100	-	-	LDO	PTHR11266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3951
SonicParanoid	1	1.000	-	-		X2546
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.780