DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1640 and ALT2

DIOPT Version :9

Sequence 1:	NP_727696.2	Gene:	CG1640 / 32292	FlyBaseID:	FBgn0030478	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_010396.1	Gene:	ALT2 / 851690	SGDID:	S000002518	Length:	507	Species:	Saccharomyces cerevisiae

Alignment Length:	500	Identity:	198/500 - (39%)
Similarity:	298/500 - (59%)	Gaps:	44/500 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 LTLDNINPNFIAMEYAVRGPLVIRAGEIEKELEKGVK-KPFDQVIRANIGDCHAMGQQPLTFLRQ 164
            :|..::|......||||||.:..||.|:::||:|..: .|||.:|.||||:...:.|:||||.||
Yeast    26 ITKKDLNTGVTKAEYAVRGAIPTRADELKEELKKNPEVLPFDDIINANIGNPQQLDQKPLTFTRQ 90

  Fly   165 LLALTFETRLLDSPDYPE-----------------DVKKRACAILNGCQGQSVGSYTDSAGLEVV 212
            :||:.         :|||                 |..:||..:||.. |.|:|:|:.|.|:..:
Yeast    91 VLAIL---------EYPEILRVGHNELASLNLFSRDALERAERLLNDI-GGSIGAYSHSQGVPGI 145

  Fly   213 RRQVAQYIEKRDGGIASNWQDIYLTGGASPGIKSILSMINAEVGCK--APGVMVPIPQYPLYSAT 275
            |:.||.:|.:||||..:..:|||||.|||....|:||::     ||  ..|:::||||||||:|:
Yeast   146 RQTVADFITRRDGGEPATPEDIYLTTGASSAATSLLSLL-----CKDSQTGLLIPIPQYPLYTAS 205

  Fly   276 ISEYGMTKVDYYLEEETGWSLDRKELQRSYDEA-KKVCNPRALVVINPGNPTGQVLTRENIEEII 339
            .|.:....:.|||:||:.||.:..|:::...:| ||...|..|:|||||||||.||:.|.|..|.
Yeast   206 ASLFNAQVLPYYLDEESNWSTNSDEIEKVVQDALKKQIRPSVLIVINPGNPTGAVLSEETIARIC 270

  Fly   340 KFAHDNKVLVLADEVYQDNVYDKNSKFWSFKKVAYEMGDPY----RNLEMVSFLSTSKGYLGECG 400
            ..|....:.:::|||||:|::: :.||.|.|||..::...|    .|:::.|..|.|||::.|||
Yeast   271 LIAAKYGITIISDEVYQENIFN-DVKFHSMKKVLRKLQHLYPGKFDNVQLASLHSISKGFMDECG 334

  Fly   401 IRGGYMEVLNLDPKVKAMLTKSITAALCSTTAGQVAVSALVNPPQPGEPSYDLYKKERDGILAAL 465
            .||||||::....:::..|.|.::.::||...||..|..:|.|||||:.||:....||..|...:
Yeast   335 QRGGYMEIIGFSQEIRDALFKLMSISICSVVTGQAVVDLMVKPPQPGDESYEQDHDERLKIFHEM 399

  Fly   466 KERAELVHKALNSFEGYKVNPVQGAMYVFPQIEIPPKAIEAAKAKGMAPDVFYAFELLETSGICI 530
            :.||.|:::.....||.:....|||||:||::.:|.||:..::..|:.||.||...|||::|||.
Yeast   400 RTRANLLYETFKELEGIECQKPQGAMYLFPRLVLPKKALCESERLGIEPDEFYCTSLLESTGICT 464

  Fly   531 VPGSGFGQKPGTWHFRSTILPQTDKLKLMMEKFRVFHAEFMKKYK 575
            ||||||||:|||:|.|:|.|....|   .::.::.||.:|..||:
Yeast   465 VPGSGFGQRPGTYHVRTTFLAPGTK---WIQDWKEFHQDFFSKYR 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1640	NP_727696.2	PTZ00377	99..575	CDD:240391	197/498 (40%)
CG1640	NP_727696.2	AAT_like	178..564	CDD:99734	162/409 (40%)
ALT2	NP_010396.1	PTZ00377	26..505	CDD:240391	196/497 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343800
Domainoid	1	1.000	296	1.000	Domainoid score	I224
eggNOG	1	0.900	-	-		E1_COG0436
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	367	1.000	Inparanoid score	I367
Isobase	1	0.950	-	0	Normalized mean entropy	S631
OMA	1	1.010	-	-		QHG61488
OrthoFinder	1	1.000	-	-		FOG0001270
OrthoInspector	1	1.000	-	-		otm46537
orthoMCL	1	0.900	-	-		OOG6_100524
Panther	1	1.100	-	-	O	PTHR11751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R36
SonicParanoid	1	1.000	-	-		X707
TreeFam	1	0.960	-	-
	15	14.740