DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1640 and gpt2

DIOPT Version :9

Sequence 1:	NP_727696.2	Gene:	CG1640 / 32292	FlyBaseID:	FBgn0030478	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001092227.2	Gene:	gpt2 / 799963	ZFINID:	ZDB-GENE-030729-8	Length:	484	Species:	Danio rerio

Alignment Length:	477	Identity:	274/477 - (57%)
Similarity:	354/477 - (74%)	Gaps:	1/477 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 KALTLDNINPNFIAMEYAVRGPLVIRAGEIEKELEKGVKKPFDQVIRANIGDCHAMGQQPLTFLR 163
            |.||:|.:||...|:|||||||:||:|||||:.||:|..|||.:||:|||||.|||||||:||||
Zfish     4 KTLTMDTLNPQVKAVEYAVRGPIVIKAGEIERCLEEGGTKPFSEVIKANIGDAHAMGQQPITFLR 68

  Fly   164 QLLALTFETRLLDSPDYPEDVKKRACAILNGCQGQSVGSYTDSAGLEVVRRQVAQYIEKRDGGIA 228
            |::||.....|::||.:|||.|.||..||.||.|.|:|||:.|||:|.:|:.:|.|||:||.|:.
Zfish    69 QVVALCTFPELMESPSFPEDAKWRARRILQGCGGHSLGSYSASAGVEYIRKDIAAYIEQRDEGVP 133

  Fly   229 SNWQDIYLTGGASPGIKSILSMINAEVGCKAPGVMVPIPQYPLYSATISEYGMTKVDYYLEEETG 293
            |||:|||||.|||.||.:||.::.:.......|||:||||||||||.|||....:|:|||:|:..
Zfish   134 SNWEDIYLTTGASDGIMTILRLLVSGKDSSRTGVMIPIPQYPLYSAAISEMDAVQVNYYLDEDNC 198

  Fly   294 WSLDRKELQRSYDEAKKVCNPRALVVINPGNPTGQVLTRENIEEIIKFAHDNKVLVLADEVYQDN 358
            |:||..||.|:|..||:.|.||.:.:||||||||||.:::.|||::.||::..:.|::|||||||
Zfish   199 WALDINELHRAYQAAKQHCQPRVICIINPGNPTGQVQSKKCIEEVLHFAYEENLFVMSDEVYQDN 263

  Fly   359 VYDKNSKFWSFKKVAYEMGDPYRN-LEMVSFLSTSKGYLGECGIRGGYMEVLNLDPKVKAMLTKS 422
            ||..:.:|.|||||.||||..|.| :|:.||.||||||.||||.|||||||:|:||:|||.|.|.
Zfish   264 VYAPDCQFHSFKKVLYEMGPEYYNSVELASFHSTSKGYTGECGFRGGYMEVINMDPEVKAQLVKL 328

  Fly   423 ITAALCSTTAGQVAVSALVNPPQPGEPSYDLYKKERDGILAALKERAELVHKALNSFEGYKVNPV 487
            ::..||...:||.|:..:||||||.|.||..:.:|:..:|.||.|:|:|..:.||:..|.|.|||
Zfish   329 LSVRLCPPLSGQAAMDVIVNPPQPDEHSYQQFHQEKSSVLGALAEKAKLTEEILNAVPGIKCNPV 393

  Fly   488 QGAMYVFPQIEIPPKAIEAAKAKGMAPDVFYAFELLETSGICIVPGSGFGQKPGTWHFRSTILPQ 552
            |||||.||:|.|||||:|.||..||.||:.|...|||.:|||:|||||||||.||:|||.||||.
Zfish   394 QGAMYAFPRIFIPPKAMEEAKTLGMQPDMLYCLRLLEETGICVVPGSGFGQKDGTYHFRMTILPS 458

  Fly   553 TDKLKLMMEKFRVFHAEFMKKY 574
            .:|||:::.|.|.||..|:|:|
Zfish   459 KEKLKVLLGKLRDFHVSFLKEY 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1640	NP_727696.2	PTZ00377	99..575	CDD:240391	274/477 (57%)
CG1640	NP_727696.2	AAT_like	178..564	CDD:99734	218/386 (56%)
gpt2	NP_001092227.2	PTZ00377	2..481	CDD:240391	274/477 (57%)
gpt2	NP_001092227.2	AAT_like	83..471	CDD:99734	218/387 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594090
Domainoid	1	1.000	420	1.000	Domainoid score	I617
eggNOG	1	0.900	-	-		E1_COG0436
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68832
Inparanoid	1	1.050	574	1.000	Inparanoid score	I1012
OMA	1	1.010	-	-		QHG61488
OrthoDB	1	1.010	-	-		D365656at33208
OrthoFinder	1	1.000	-	-		FOG0001270
OrthoInspector	1	1.000	-	-		otm25088
orthoMCL	1	0.900	-	-		OOG6_100524
Panther	1	1.100	-	-	O	PTHR11751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R36
SonicParanoid	1	1.000	-	-		X707
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800