DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1640 and gpt

DIOPT Version :9

Sequence 1:	NP_727696.2	Gene:	CG1640 / 32292	FlyBaseID:	FBgn0030478	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_017213488.1	Gene:	gpt / 403086	ZFINID:	ZDB-GENE-050302-11	Length:	549	Species:	Danio rerio

Alignment Length:	492	Identity:	277/492 - (56%)
Similarity:	360/492 - (73%)	Gaps:	1/492 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 VRRSFSTSHKMPSSSKALTLDNINPNFIAMEYAVRGPLVIRAGEIEKELEKGVKKPFDQVIRANI 148
            :::..|.:..:|...|.||:|.:|.|...::||||||:|.||.:|||||::|||||||:||:|||
Zfish    57 MQQKMSENGAIPRQGKVLTVDTMNANVKKVDYAVRGPIVQRAVQIEKELKEGVKKPFDEVIKANI 121

  Fly   149 GDCHAMGQQPLTFLRQLLALTFETRLLDSPDYPEDVKKRACAILNGCQGQSVGSYTDSAGLEVVR 213
            ||.|||||:|:||.||::||....:|||...:|||.|.||..||..|.|.|:|:||.|.|::.||
Zfish   122 GDAHAMGQRPITFFRQVMALCTYPQLLDDNKFPEDAKNRARRILQSCGGNSIGAYTTSQGIDCVR 186

  Fly   214 RQVAQYIEKRDGGIASNWQDIYLTGGASPGIKSILSMINAEVGCKAPGVMVPIPQYPLYSATISE 278
            :.||:|||:|||||.|:..:||||.|||.||.:||.::.|..|....|||:.|||||||||:|:|
Zfish   187 QDVAKYIERRDGGIPSDPDNIYLTTGASDGIVTILKLLTAGEGLTRTGVMISIPQYPLYSASIAE 251

  Fly   279 YGMTKVDYYLEEETGWSLDRKELQRSYDEAKKVCNPRALVVINPGNPTGQVLTRENIEEIIKFAH 343
            .|..:::|||.||..||||..|||||...|:|.||||.|.:||||||||||.:|:.||::|:||.
Zfish   252 LGAVQINYYLNEEKCWSLDISELQRSLQAARKHCNPRVLCIINPGNPTGQVQSRQCIEDVIQFAA 316

  Fly   344 DNKVLVLADEVYQDNVYDKNSKFWSFKKVAYEMGDPY-RNLEMVSFLSTSKGYLGECGIRGGYME 407
            ...:.::||||||||||.|..:|.|||||.:|||..| :.:|:.||.||||.|:||||.||||||
Zfish   317 KENLFLMADEVYQDNVYAKGCEFHSFKKVLFEMGPEYSKKVELASFHSTSKCYMGECGFRGGYME 381

  Fly   408 VLNLDPKVKAMLTKSITAALCSTTAGQVAVSALVNPPQPGEPSYDLYKKERDGILAALKERAELV 472
            |:|:|..|||.|||.::..||....||..:..:||||||||||:..:.:||..:|:||.|:|:|.
Zfish   382 VINMDADVKAQLTKLVSVRLCPPAPGQALMDLVVNPPQPGEPSHQTFMQERTAVLSALAEKAKLT 446

  Fly   473 HKALNSFEGYKVNPVQGAMYVFPQIEIPPKAIEAAKAKGMAPDVFYAFELLETSGICIVPGSGFG 537
            .:.||:..|...||||||||.||:|.:|.:||..|||||.|||:||..:|||.:|||:|||||||
Zfish   447 EQILNTVPGISCNPVQGAMYSFPRITLPERAISEAKAKGQAPDMFYCMKLLEETGICLVPGSGFG 511

  Fly   538 QKPGTWHFRSTILPQTDKLKLMMEKFRVFHAEFMKKY 574
            |:.||:|||.||||.|||||||:.|.:.||..|.::|
Zfish   512 QREGTYHFRMTILPPTDKLKLMLNKLKDFHQRFTQQY 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1640	NP_727696.2	PTZ00377	99..575	CDD:240391	275/477 (58%)
CG1640	NP_727696.2	AAT_like	178..564	CDD:99734	222/386 (58%)
gpt	XP_017213488.1	PTZ00377	70..549	CDD:240391	275/479 (57%)
gpt	XP_017213488.1	AAT_like	176..528	CDD:99734	202/351 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594088
Domainoid	1	1.000	420	1.000	Domainoid score	I617
eggNOG	1	0.900	-	-		E1_COG0436
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	574	1.000	Inparanoid score	I1012
OMA	1	1.010	-	-		QHG61488
OrthoDB	1	1.010	-	-		D365656at33208
OrthoFinder	1	1.000	-	-		FOG0001270
OrthoInspector	1	1.000	-	-		otm25088
orthoMCL	1	0.900	-	-		OOG6_100524
Panther	1	1.100	-	-	LDO	PTHR11751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R36
SonicParanoid	1	1.000	-	-		X707
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.840