DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1640 and CG1461

DIOPT Version :9

Sequence 1:	NP_727696.2	Gene:	CG1640 / 32292	FlyBaseID:	FBgn0030478	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001285238.1	Gene:	CG1461 / 32381	FlyBaseID:	FBgn0030558	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	126/549 - (22%)
Similarity:	217/549 - (39%)	Gaps:	151/549 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IKPAAATVSAALQQHQRQQQQYVIRRWKSFLHNNSNNANRRAAKSTATATVTAAATSQRHG--TS 75
            :.|....|..||.:.|.|.|..                  |..:.....|.|::::.:|.|  ..
  Fly    36 VTPNCDVVDQALAELQLQSQDI------------------RKQQDLVDTTATSSSSRKRSGWEIK 82

  Fly    76 GDFIQPLDVRRSFSTSHKMPSSSKALTLDNINPNFIAMEYAVRGPLVIRAGEIEKELEKGVKKPF 140
            |.       :.|.:|.:::.:..::|   .|.||                             |.
  Fly    83 GS-------KLSLNTHNRIRNIVESL---KIKPN-----------------------------PE 108

  Fly   141 DQVIRANIGDCHAMGQQPLTFLRQLLALTFETRLLDSPDYPEDVKKRACAILNGCQGQSVGSYTD 205
            ..:|..:|||       |.||..           |.:.|  |.:|    |:|:..:......|..
  Fly   109 KPMIPLSIGD-------PTTFGN-----------LKAAD--ETMK----AVLHSLESGKYNGYAS 149

  Fly   206 SAGLEVVRRQVAQYI--EKRDGGIASNWQDIYLTGGASPGIK-SILSMINAEVGCKAPGVMVPIP 267
            :.|.|:.|:.||:|.  ::.||.|.:|  ::.|..|.|..:: .||::.:     :...|:||.|
  Fly   150 TQGHEIARKAVAKYSAHQRPDGEIDAN--EVVLCSGCSSALEYCILALAD-----RGQNVLVPRP 207

  Fly   268 QYPLYSATISEYGMTKVDYY-LEEETGWSLDRKELQRSYDEAKKVCNPRALVVINPGNPTGQVLT 331
            .:.|| .|:::....:|.|| |..:..|..|..:|:...||     |..||::.||.||.|.|..
  Fly   208 GFCLY-YTLAQGLDIEVRYYDLLPDQQWRADLVQLESLIDE-----NTAALLINNPSNPCGSVFD 266

  Fly   332 RENIEEIIKFAHDNKVLVLADEVYQDNVYDKNSKFWSFKKVAYEMGDPYRNLEMVSFLSTSKGYL 396
            .:::.|:|.....:.:.::|||:|:..|: ..||..:...:..|       :.::|....:|.:|
  Fly   267 EKHLRELIAICERHYLPIIADEIYEHFVF-PGSKHLAVSSLTTE-------VPVLSCGGLTKRFL 323

  Fly   397 GECGIRGGYMEVLNLDPKVKAMLT--KSITA-ALCSTTAGQVAV-SALVNPPQPGEPSYDLYKKE 457
            .. |.|.|::.|.:...:::..:.  |::.. .|.|.|..|.|: ..|...||    ||
  Fly   324 VP-GWRMGWIIVHDRKNRLRDAIVGLKNMCGRILGSNTIIQGALPDILTKTPQ----SY------ 377

  Fly   458 RDGILAALKERAELVHKALNSFEGYKVNPV--QGAMYV--------FPQIEIPPKAIEAAKAKGM 512
            .||::..|...|.|.:|.|....|  ::||  .||||:        ||:.:
  Fly   378 FDGVIDVLHSNAMLAYKMLKQVRG--LDPVMPNGAMYMMIGVSIERFPEFK-------------- 426

  Fly   513 APDVFYAFELLETSGICIVPGSGFGQKPG 541
             .|..:..|::....:..:|||.| :.||
  Fly   427 -DDTHFVQEMVNEQSVFCLPGSCF-EYPG 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1640	NP_727696.2	PTZ00377	99..575	CDD:240391	111/461 (24%)
CG1640	NP_727696.2	AAT_like	178..564	CDD:99734	98/382 (26%)
CG1461	NP_001285238.1	tyr_amTase_E	79..481	CDD:273529	114/488 (23%)
CG1461	NP_001285238.1	AAT_like	112..475	CDD:99734	106/416 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467879
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0436
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740