DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1640 and SPBC582.08

DIOPT Version :9

Sequence 1:	NP_727696.2	Gene:	CG1640 / 32292	FlyBaseID:	FBgn0030478	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_595176.1	Gene:	SPBC582.08 / 2540891	PomBaseID:	SPBC582.08	Length:	505	Species:	Schizosaccharomyces pombe

Alignment Length:	487	Identity:	203/487 - (41%)
Similarity:	288/487 - (59%)	Gaps:	25/487 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 LDNINPNFIAMEYAVRGPLVIRAGEIEKE-LEKGVKKPFDQVIRANIGDCHAMGQQPLTFLRQLL 166
            |:::|.......|||||.|.|.|.||:.: ||.....||.:::.||||:...|||.|:||:||:|
pombe    30 LNSLNQQVFKANYAVRGALAILADEIQDDLLENPSSYPFSEIVYANIGNPQQMGQSPITFVRQVL 94

  Fly   167 ALTFETRLLDSPD-------YPEDVKKRACAILNGCQGQSVGSYTDSAGLEVVRRQVAQYIEKRD 224
            :|.....|||..:       :|.||.:|:..:|.  :..|:|:|:.|.|:.:|||.||.:|..||
pombe    95 SLCQYPTLLDHAEEKWFQNLFPTDVVQRSKMLLK--ESGSLGAYSASQGIPLVRRHVADFIRARD 157

  Fly   225 GGIASNWQDIYLTGGASPGIKSILSMINAEVGCKAPGVMVPIPQYPLYSATISEYGMTKVDYYLE 289
             |......|||||.|||...:.|:::|.|.   ...|||||.||||||.|.|.....:.|.|.|.
pombe   158 -GFDCEPSDIYLTSGASHAARLIMTLIIAR---PTDGVMVPAPQYPLYGAQIDLMSGSMVSYSLS 218

  Fly   290 EETGWSLDRKELQRSYDEA-KKVCNPRALVVINPGNPTGQVLTRENIEEIIKFAHDNKVLVLADE 353
            ||..|.:|..:.::|:||| ||..|.|..||||||||||..::..::|::::||....:::||||
pombe   219 EENNWDIDFDQFKKSFDEASKKGINVRLCVVINPGNPTGACISENSMEKVLRFAKAKGIVLLADE 283

  Fly   354 VYQDNVYDKNSKFWSFKKVAYEM--GDPYRNLEMVSFL---STSKGYLGECGIRGGYMEVLNLDP 413
            |||:|:|  .:||.||::...|:  .:|..:.:.||.:   |.|||..||||.||||::|:|:..
pombe   284 VYQNNIY--QNKFHSFRRKLGELREKEPDNHWDQVSLISVNSVSKGQFGECGQRGGYLDVVNIPE 346

  Fly   414 KVKAMLTKSITAALCSTTAGQVAVSALVNPPQPGEPSYDLYKKERDGILAALKERAELVHKALNS 478
            ..|..:.|..|..:|...|||:.|..|||||:||:|||||:.||.|.|..||:.:...:::....
pombe   347 PAKDQILKLATIDICPPVAGQLLVDMLVNPPKPGDPSYDLFIKEVDEIHEALRLQCRQLYEGTKR 411

  Fly   479 FEGYKVNPVQGAMYVFPQIEIPPKAIEAAKAKGMAPDVFYAFELLETSGICIVPGSGFGQKPGTW 543
            .:........||||:.|.:.:|.|.|..|||:.:.||.|||.|||:.||||:||||||||..|.:
pombe   412 MKRVSCLEPHGAMYLHPSVSLPEKLITTAKAQKIQPDEFYAIELLKRSGICVVPGSGFGQPEGDY 476

  Fly   544 HFRSTILPQTDKLKLMMEKFRVFHAEFMKKYK 575
            |.|.|.|.:..:   .:|:|...|.|.|..|:
pombe   477 HIRITFLAKGTE---YIERFVKAHNEIMDLYE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1640	NP_727696.2	PTZ00377	99..575	CDD:240391	202/485 (42%)
CG1640	NP_727696.2	AAT_like	178..564	CDD:99734	165/398 (41%)
SPBC582.08	NP_595176.1	PTZ00377	23..504	CDD:240391	202/484 (42%)
SPBC582.08	NP_595176.1	AAT_like	116..499	CDD:99734	167/393 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	288	1.000	Domainoid score	I286
eggNOG	1	0.900	-	-		E1_COG0436
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68832
Inparanoid	1	1.050	349	1.000	Inparanoid score	I483
OMA	1	1.010	-	-		QHG61488
OrthoFinder	1	1.000	-	-		FOG0001270
OrthoInspector	1	1.000	-	-		oto100541
orthoMCL	1	0.900	-	-		OOG6_100524
Panther	1	1.100	-	-	LDO	PTHR11751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R36
SonicParanoid	1	1.000	-	-		X707
TreeFam	1	0.960	-	-
	14	13.860