DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmrt11E and DMRTA1

DIOPT Version :9

Sequence 1:	NP_511146.2	Gene:	dmrt11E / 32291	FlyBaseID:	FBgn0030477	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_071443.2	Gene:	DMRTA1 / 63951	HGNCID:	13826	Length:	504	Species:	Homo sapiens

Alignment Length:	196	Identity:	67/196 - (34%)
Similarity:	93/196 - (47%)	Gaps:	40/196 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 RTPKCARCRNHGVISCVKGHKRLCRWRECCCPNCQLVVDRQRVMAAQVALRRQQTMEALEATA-S 181
            |||||||||||||:|.:|||||.||||:|.|..|.|:.:|||||||||||||||..|..||.. .
Human    93 RTPKCARCRNHGVVSALKGHKRFCRWRDCACAKCTLIAERQRVMAAQVALRRQQAQEESEARGLQ 157

  Fly   182 STKSTGVTTASANNSSSSEGE-DSLSSTSPPPAHSHPHSHSHPTSCVSNSSSSSATRQALMAQKR 245
            ....:|::......:|...|. ::..||..|.|.:                       ||
Human   158 RLLCSGLSWPPGGRASGGGGRAENPQSTGGPAAGA-----------------------AL----- 194

  Fly   246 IYKQRLRSLQQSTLHITAAMEEYKQRFPTFSSPLMERMRKRRAFADPELNHVMEATLGGNALYFA 310
                .|.:|:|::...|.|.|.::|.:|.      |:..::.:..:...|...|.....:.||..
Human   195 ----GLGALRQASGSATPAFEVFQQDYPE------EKQEQKESKCESCQNGQEELISKSHQLYLG 249

  Fly   311 T 311
            :
Human   250 S 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmrt11E	NP_511146.2	DM	118..164	CDD:279137	33/45 (73%)
DMRTA1	NP_071443.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		DM	93..139	CDD:279137	33/45 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..192		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..307
		CUE_DMA_DMRTA1	325..364	CDD:270600
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900